'Here, we analyzed #lysosome subcellular distribution in micropatterned patient-derived melanoma cells and found that lysosome spreading scales with their aggressiveness.'
#Preprint #Melanoma

https://www.biorxiv.org/content/10.1101/2023.07.07.548108v1

TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers

Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn

RT @KristineSchaue1
Have a read how we zoom on #lysosome #organelles @GustaveRoussy to understand what is wrong in bladder #cancer cells. Big thanks to all authors but particularly to @pallavimathur for great PhD work! https://twitter.com/CommsBio/status/1620694062868070408

Are you ready for your reading list for the week?

Check out this week's edition of publications on #MembraneContactSites!

http://biomed.news/bims-mecosi/2023-01-29

Thanks to #BioMedNews, an abstract-selection tool based on #ArtificialIntelligence and #MachineLearning!

#MAMs #MCS #Mitochondria #Lysosome #Proteostasis

Impairment of lipid homoeostasis causes accumulation of protein aggregates in the lysosome

#preprint #biorxiv #lysosome

https://www.biorxiv.org/content/10.1101/2022.11.23.517579v1