Groundbreaking ceremony for the new building of the Helmholtz Institute for Translational Oncology #HI-TRON in Mainz (Germany), providing a space for novel cutting-edge #immunotherapy development, #personalizedmedicines and #mRNAs as tools in #cancer #research @mainz_de @unimainz @helmholtz @hereon @dkfz
https://www.dkfz.de/de/presse/pressemitteilungen/2023/dkfz-pm-23-33a-HI-TRON-Mainz-ein-Helmholtz-Institut-des-DKFZ-erhaelt-neues-Gebaeude.php

ADENOVIRUS VS RNA

Un nuovo studio ha messo a confronto, in assenza di infezioni pregresse, il vaccino di Astra Zeneca con quello di Pfizer.
I dati ottenuti sono interessanti, soprattutto in vista dello sviluppo di futuri prodotti.

#vaccines #adenovirus #mRNAs

https://www.ilfoglio.it/scienza/2023/02/24/news/nuove-verita-e-scoperte-sui-vaccini-contro-il-covid-19-tra-efficacia-ed-effetti-avversi-4989740/amp/

MRNA was discovered in the early 1960's, John Hopkins states. Some were used to fight the Ebola virus. Researchers are also currently working to use mRNA to prevent other respiratory viruses.

According to the National Cancer Institute, mRNA vaccines are being studied to treat people with various types of cancer. The research that was done to treat people with cancer before the pandemic struck helped spearhead the COVID vaccine, the NCI says.

#moreyouknow #covid #cancer #vaccines #mRNAs #virus

https://www.ktvb.com/article/news/local/capitol-watch/idaho-lawmakers-introduce-legislation-to-criminalize-those-who-administer-covid-vaccines-legislature/277-2436a514-e7da-4b31-9762-f9be10300075

Seeing #mRNAs in cells, often involves the addition of MS2 binding sites in the 3' #UTR that can be detected with fluorescent #MS2 coat protein. The MS2 binding site repeats increase the size of the 3' UTR and can also affect the degradation of #RNA fragments containing them: https://pubmed.ncbi.nlm.nih.gov/30218101/

Longer 3' UTR induce the degradation of the RNA of interest through nonsense-mediated mRNA decay (NMD). This can be avoided by tethering #eRF3 or a mutant #PAB1.
https://www.biorxiv.org/content/10.1101/2022.02.05.479257v1.full