"scientists 'have now discovered that treatment with #mAbs comes with a serious trade-off; SARS-CoV-2 mutates in response to the immune-pressure created under mAb-treatment along with host immune responses. This also means that the virus can develop resistance to mAbs—similar to resistance emergence under antibiotic treatments in bacterial infections.'"

https://medicalxpress.com/news/2023-02-dark-side-covid-monoclonal-antibodies.html

#COVID #SARSCoV2 #MonoclonalAntibodies #Mutation

The BQ family of covid variants now comprise ~32% of US cases. (H/t @tRAJectory)
As such, the FDA has revoked the EUA for the monoclonal antibody bebtelovimab.
This means we are out of MABs for the general population. Covid has smashed through them all.
MABs were the last line of defense for very ill patients.

#maskup #covid #sarscov2 #Pandemic #mabs #beptelovimab #FDA

https://nitter.it/bmore_radical/status/1597057435700981762?s=46&t=Ct3dsMPDbi_bYmhN96m0Wg
👏🏼THIS👏🏼IS👏🏼NOT👏🏼HOW👏🏼ANY👏🏼OF👏🏼THIS👏🏼WORKS👏🏼
There is no #durable #immunity to #coronaviruses period especially when it #mutates #variants super quickly

For a well-respected #medicalSchool to do this is #appalling #reprehensible & it’s an outright #lie to say defenses have gotten stronger when NONE OF THE #MABs work anymore #ItsNotACold #CovidZero #Reinfection #IWantMyNovavax #WearADamnGoodMask #ventilate #AirFiltration #kitchenSink #asymptomatic

@rbreich Other major issues at work are: 1. Easy $$ on existing revenue streams protected by gov't rules (FDA, etc) that limit competition; 2. Little C-level $$ incentive to pursue risky research projects (why risk bonus $$?). This has major downstream consequences to world-wide health as evidenced by virtually no #R&D on new #antibiotics & major focus on #diseases that can be addressed by #monoclonal #antibodies, which cost much less for big Pharma to develop. Profit margins on #mAbs are HUGE.