#IDMastodon #Cellular & #MolecularImmunology The more I learned about the nature of #COVID & the more ‘I ‘m lost for words ’ This 🦠 is nasty & sophisticated than anykind ..😷💉is one step ahead the crowd . A high infection rate by #SarsCoV2 may lead to exaggerated #cytokine responses, which may contribute to tissue damage & severe disease.
#Macrophage #phagocytosis of #SARSCoV2-infected cells mediates potent #plasmacytoiddendriticcell activation
https://www.nature.com/articles/s41423-023-01039-4

#lncRNAs can affect #macrophage M1/M2 polarization:
@mimaseestern et al @Savai_Lab @mpi_hlr find ADPGK-AS1 expression associated with tumor-associated macrophages to alter metabolic and phenotypic states to drive #lungcancer growth
https://www.embopress.org/doi/full/10.15252/embj.2022111620

Macrophages aren't defined by binary M1 & M2 classification, but are plastic and come in many flavours.

Here it's expression of CXCL9 and SPP1, and it associated with tumour microenvironment.

#immunology #cancer #tumor #macrophage #science #ScienceMastodon

https://www.science.org/doi/abs/10.1126/science.ade2292?af=R&utm_source=sfmc&utm_medium=email&utm_campaign=SCIeToc&utm_content=alert&et_rid=79524916&et_cid=4843975

In @sciencemagazine this week, Ziegler, Engelhardt & al report that #sleep disruption in #HeartDisease is driven #macrophage-mediated loss of #neurons projecting from the #SuperiorCervicalGanglia into the #PinealGland!

http://bit.ly/Sci_abn6366

Be sure to also check out the outstanding Perspective on this paper penned by Harvey Davis & David Atwell!

http://bit.ly/Sci_adj0217

'Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland–innervating neurons.'

#immunology #Macrophage #Neuroimmunology

https://www.science.org/doi/10.1126/science.abn6366

“Overall, this paper shows for the first time a unique population of macrophages that emerges specifically during lactation and is of interest to immunologists, particularly macrophage biologists."

#Immunology #Macrophage #MucosalImmunology

https://www.nature.com/articles/s41590-023-01531-z

@gpollara It also raises the question, whether phagocytosing capabilities and surface markers are really correctly attributed already...and if we might need an update of our classification system for inflammatory states also... #macrophage #neutrophil

How Tattoos Interact With The Immune System Could Have Impacts for Vaccines https://hackaday.com/2023/04/05/how-tattoos-interact-with-the-immune-system-could-have-impacts-for-vaccines/ #CurrentEvents #MedicalHacks #immunesystem #macrophages #immunology #macrophage #Featured #Interest #Science #vaccine #immune #tattoo #ink

How Tattoos Interact With The Immune System Could Have Impacts for Vaccines - Tattoos are an interesting technology. They’re a way of marking patterns and desig... - https://hackaday.com/2023/04/05/how-tattoos-interact-with-the-immune-system-could-have-impacts-for-vaccines/ #currentevents #medicalhacks #immunesystem #macrophages #immunology #macrophage #featured #interest #science #vaccine #immune #tattoo #ink

💥 There you go. Autophagy **is** important in restricting growth of Mycobacterium tuberculosis in human macrophages. 💥

#crispr #macrophage #tuberculosis #tb #Science #immunology https://www.nature.com/articles/s41564-023-01335-9

Uptake-independent killing of macrophages by extracellular #Mycobacterium #tuberculosis aggregates

Chiara Toniolo et al show that Mtb aggregates evade #phagocytosis by inducing #macrophage #pyroptosis via a mechanism involving its type VII secretion system ESX-1 and surface lipid PDIM

https://www.embopress.org/doi/10.15252/embj.2023113490

'Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary necrosis and autoimmune activation by intracellular self antigens. We show by multiple redundant and complementary methods that TBMs derive from a lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor that is prepositioned in the follicle.'

#immunology #Macrophage #Apoptosis #GerminalCenter

https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X

RT @KonradHoeft
We are so thrilled to see our new study out in @CellReports today (https://bit.ly/3XJ5MXB)! We investigated #platelet-#macrophage-crosstalk in #fibrosis identifying a platelet-instructed SPP1 macrophage subset that controls fibroblast activation. 1/11

RT @KonradHoeft
We are so thrilled to see our new study out in @CellReports today (https://bit.ly/3XJ5MXB)! We investigated #platelet-#macrophage-crosstalk in #fibrosis identifying a platelet-instructed SPP1 macrophage subset that controls fibroblast activation. 1/11

"We show that self-renewing DRGMacs contribute to promote axon regeneration. Using single-cell transcriptomics data and CellChat to simulate intercellular communication, we reveal that macrophages express the neuroprotective and glioprotective ligand prosaposin and communicate with SGCs via the prosaposin receptor GPR37L1."

#immunology #Macrophage #neuroscience #Regeneration

https://www.pnas.org/doi/10.1073/pnas.2215906120

Really enjoyed the #SIGNET2023, many interesting talks, nice chats, see you next year!!
@TSimakou
#MyeloidRulez #DC #Macrophage

"This review aims to consolidate past and current studies investigating the complexity of the miRNA interactome to provide the reader with a mechanistic view of how miRNAs shape macrophage behavior."

#Immunology #Macrophage #miRNAs

https://journals.aai.org/jimmunol/article-abstract/210/4/359/237698/MicroRNAs-in-Macrophages-Regulators-of-Activation?redirectedFrom=fulltext

The final 'First person' interview in our current Issue is with Aarthi Subramani on her PhD project in the lab of David E. Nelson at the Middle Tennessee State University, Murfreesboro, USA, investigating the interaction of host and pathogen at the cellular and molecular levels: https://journals.biologists.com/jcs/article/136/1/jcs260894/286225/First-person-Aarthi-Subramani
#cellbiology #research #macrophage #interferon

Eric Leif Sander et al

december 2021

#SarsCov2 infection triggers profibrotic #macrophage responses & lung #fibrosis

https://doi.org/10.1016/j.cell.2021.11.033

"Here, we review how nutrient acquisition through plasma membrane transporters and engulfment pathways control tumor-associated macrophage differentiation and function. We also discuss how nutrient metabolism regulates tumor-associated macrophages and how these processes may be targeted for cancer therapy."
@ImmunityCP
#Metabolism #Immunology #Immunotherapy #Review #Macrophage

https://www.cell.com/immunity/fulltext/S1074-7613(22)00639-2