.@FengYang_MedBio &co show that #MAPK4 promotes PDK1 protein synthesis and thus also activates PDK1 substrates beyond AKT to promote #cancer. Co-targeting AKT & PDK1 may help treat MAPK4-high cancers like "#TripleNegative" #BreastCancer #PLOSBiology https://plos.io/43NCCK0