#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200

RT @SwissChemistry
❗️Peptide Therapeutics Forum 2023 - Last chance to submit your abstract for a contributed talk❗️
🗓️Sep 4-5 @UniBasel_en
Zentrum für Lehre und Forschung
https://ptf23.scg.ch
#chemistry #peptides #scs #ptf23 #medchem #unibas #symposia #switzerland

RT @SwissChemistry
📢Peptide Therapeutics Forum 2023
🗓️Sep 4-5 @UniBasel_en Zentrum für Lehre und Forschung
Submit your abstract for a contributed talk until March 31 via https://ptf23.scg.ch
#chemistry #peptides #scs #ptf23 #medchem #unibas #symposia #switzerland

RT @HartungIngo
We have a job opening in our MedChem department in Darmstadt/GER (Frankfurt area): Join us to discover the next generation of drugs in oncology & immunology (small molecule inhibitors & degraders). Candidates with hands-on #MedChem experience preferred. https://www.merckgroup.com/en/careers/jobs/261866.html

RT @cressetgroup
💬 A glowing review for Flare™ from The University of Cambridge!

⭐⭐⭐⭐⭐

https://www.cresset-group.com/software/flare/

#university #academia #drugdiscovery #medicinalchemistry #drugdesign #medchem #computationalchemistry #compchem #cheminformatics #CADD

Small review about synthetic routes to #antiviral #drug remdesivir. Including first described synthesis by Gilead in #Nature, but also the approach from Benjamin List in Angewandte Chemie.

https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-of-antiviral-nucleoside-analogue-remdesivir

#chemistry #medchem #covid

I wrote a short excerpt about the #SARS-CoV-2 #antiviral VV116 which was developed in #China. Structurally, it resembles #remdesivir but esterification led to much better bioavailability. Therefore, it can be administered orally.

Any opinions on this nucleoside analogue?

@chemistry #chemistry #medchem

https://www.organicchemistry.eu/books/nucleoside-analogues/page/sars-cov-2-antiviral-vv116

Design of CD73 #inhibitor|s

Introduction of 3' alkynyl moiety led to drastically improved antitumor activity. E. B. Sjogren and colleagues from Calithera Biosciences described the synthesis of these orally available nucleoside analogues in the Journal of Medicinal #Chemistry.

#MedChem @chemistry #Science #Research

https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01287

Design of CD73 #inhibitor|s

Introduction of 3' alkynyl moiety led to drastically improved antitumor activity. E. B. Sjogren and colleagues from Calithera Biosciences described the synthesis of these orally available nucleoside analogues in the Journal of Medicinal #Chemistry.

#MedChem @chemistry #Science #Research

https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01287

Our chemical tool #BCL6 #degrader is now available for free from the SGC as part of their donated chemical probes programme. We are very pleased to support this initiative which enables researchers to access quality tool compounds for their research. Remarkably, this is the first approved degrader on their list, with no doubt many more to follow! https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/CCT369260 #chemicalprobes #medchem #DrugDiscovery #tpd

Announcement I've been sitting on: I'm joining UCI's new Institute for Neurotherapeutics! While Rob Spitale (@SpitaleLab@twitter.com) is affiliated with the INT he is on leave from the university (hence my job change) and I'll be working for Brian Paegel (@BrianDNA@twitter.com) and INT director Al La Spada.

https://news.uci.edu/2022/10/18/uci-launches-center-for-neurotherapeutics-to-facilitate-drug-discovery-and-therapy-delivery/

#UCI #Neurotherapeutics #Chemistry #ChemicalBiology #ChemBio #ChemiVerse #MedChem #MedicinalChemistry #DrugDiscovery #Collaboration #Science

Carbasugar #nucleoside analogues often lack biological activity, which is attributed to an unfavorable conformation. Locked nucleoside analogues, however, can mantain the ribose-like conformation. Another synthetic access is published in #OrgLett by Lak Shin Joeng and colleagues from Seoul National University (S. #Korea)

They were able to report the synthesis of the conformationally locked cytidine nucleoside analogue in 19 steps.

#chemistry #MedChem @chemistry
https://pubs.acs.org/doi/10.1021/acs.orglett.2c03853

A nice overview on #PCSK9 #inhibitors and related #medchem opportunities.
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c01290

A nice overview on #pcsk9 #inhibitors and releted #medchem opportunities
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c01290

RT @mlbolognesi@twitter.com

Two new PhD positions to work on exciting #medchem projects available @B2f2Phd@twitter.com @Unibo@twitter.com 🇮🇹 (see below) 👇
Retweets are highly appreciated, thank you 🙏

🐦🔗: https://twitter.com/mlbolognesi/status/1597594194243211264

Reading and learning about the design of nucleoside analogues. Any recommendations?

#chemistry #medchem

RT @SCIFineChem@twitter.com

REGISTRATION NOW OPEN! CALL FOR POSTER ABSTRACTS. 7th RSC-BMCS/SCI symposium on Ion Channels as Therapeutic Targets; 27th-28th March 2023, Cambridge
Full programme: https://lnkd.in/e2Taqxuk
Abstract deadline 31st Dec #medchem #ionchannels #IonChannels23

🐦🔗: https://twitter.com/SCIFineChem/status/1596057544384024576

Since I've switched servers, here is my #introduction:

I'm still a scientist, even if I don't work in a lab. I studied organic #chemistry. I was in #medchem, then I was in #patents, then I was in information science. I am very excited to be starting a new job next month!

Interests:

New drugs

Old drugs used in a new way
Disease pathology

Social determinants of health
Knowledge graphs
 AI/NLP/semantic analysis
#scicomm


#baseball
#mastodogs
#cooking 
#beer #cocktails

#altchemjobs

Hi Mastodon, I'm Geordi! I'm a #medchem/#chembio PhD student in Scott Prosser and Patrick Gunning's labs at the University of Toronto Mississauga! Lately, I've taken an interest in #targetedproteindegradation and I wrote a chapter on molecular glue degraders in MCB: Biomolecular Interactions! (1/2)
https://www.sciencedirect.com/science/article/pii/S0091679X22000012?via%3Dihub

A while back (2019) I wrote a review paper on the chemical modulation of two-pore domain (K2P) ion channels. The paper has been cited in top journals, including Nature. I think it is still a good reference for anyone interested. #ionchannels #medchem
https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13571