Clearly, there is still much to learn about this corner of the dark genome defined by HEATR5 proteins and their co-factors.

#Biorxiv #Preprint #MembraneTraffic #DarkGenome #DarkProteome #RareDisease #AlphaFold #AlphaFold2 #ProteinPrediction #Golgi #Clathrin #CellBiology #biochemistry #Bioscience

This preprint from Groza et al. (Helge Ewers lab) looks really interesting. Exploring how particles (such as virions) gain entry to cells. Really neat application of synthetic tools to show that overcoming energy for membrane deformation is the key step to endocytosis.

https://www.biorxiv.org/content/10.1101/2023.06.23.546235v1

#CellBiology #MembraneTraffic #Virology

#Introduction (just moved to new instance)

I am a cell biologist running a research group (@roylelab) focused on membrane traffic and cell division in human cells. My lab is in @Warwick_CMCB at #WarwickUni. My posts are mainly about #science and #CellBiology but also #music, #running and #cycling.

My previous handle was clathrin. For my data analysis alter-ego, follow @quantixed.

#Microscopy #ImageAnalysis #MembraneTraffic #Mitosis #OpenScience #RStats

Faculty Opinions recommendation of our MitoPits paper (Küey et al. - Recruitment of clathrin to intracellular membranes is sufficient for vesicle formation)

https://facultyopinions.com/article/742258825

#CellBiology #MembraneTraffic

Steve is presenting Méghane's work on transport of small vesicles inside cells this morning at the UCL-CMCB Workshop on Mechanobiology.

#CellBiology #MembraneTrafficking #MembraneTraffic

Yesterday we @roylelab celebrated 125 years since the discovery of the Golgi with Italian snacks from my recent trip to Rome with @simonecoppola! Feat. a cuddly Golgi borrowed from a mini @clathrin and Golgi earrings gifted to me by my colleague and friend Thilani! Thanks to fellow Golgi fans Felix Campelo and Ishier Raote for the inspiration - I might make this a yearly thing!

#cellbiology #membranetraffic #sciencenerds

Marino Zerial to take over from Iain Mattaj as Director of @humantechnopole

https://humantechnopole.it/en/news/marino-zerial-appointed-as-new-human-technopole-director/

#MembraneTraffic #CellBiology #AcademicTransferMarket

Today's #preprintOTD https://www.biorxiv.org/content/10.1101/2023.02.16.528797v1
"Evolution of the ribbon-like organization of the Golgi apparatus in animal cells"
Golgi structure, ribbon formation, golgins etc #membranetraffic

This new paper from Obashi and colleagues in the Taraska lab is very nice. It uses a FRET-CLEM approach to look at protein conformations in cells and tie those to ultrastructural correlates. Here they are looking at clathrin light chain dynamics relative to the clathrin cage during #endocytosis, but there are many other questions in cell biology where this could be applied.

https://doi.org/10.1038/s41467-023-36304-7

#CellBiology #StructuralBiology #ElectronMiscroscopy #MembraneTraffic

Our lab has TWO #PostDoc positions available!

1. Three year project on #MembraneTraffic, physical forces and neuronal #CellBiology. Closing 12th Feb.
https://bit.ly/3GTORvi

2. 1.5 year post on intracellular transport vesicle movement and molecular characterisation. Closing 6 March.
https://bit.ly/3jz0JLm
https://www.linkedin.com/jobs/view/3464435931/

Come and join us in sunny (sometimes) #Warwick. Friendly team, kick ass #CellBiology, cool #microscopy, supportive PI (@clathrin) and environment @Warwick_CMCB

Really interesting work from Jon Audhya's lab came out last year which I'm just catching up on.
https://www.pnas.org/doi/10.1073/pnas.2210649119
Shows that TFG, a protein known to be involved in COPII-dependent export of secretory cargo from the ER, is also needed for Rab4-dependent trafficking in neurons. This appears to be unique to the central nervous system and likely explains the impact of TFG p.R106C in early-onset forms of hereditary spastic paraplegia.
#membranetraffic

Mary Fesenko @MAFesenko is giving today's @Warwick_CMCB talk. She'll be presenting her work on one particular flavour of intracellular nanovesicle. 1pm TODAY

#CellBiology #seminar #WarwickUni #MembraneTraffic

Microtubule-Maniacs and Motorheads:

7th UK #Microtubule Meeting - 12th May 2023, Edinburgh. Organised by Julie Welburn, Andrew Carter and Mark Dodding.

microtubule.bio.ed.ac.uk

#CellBiology #Cytoskeleton #MembraneTraffic

The UK #Microtubule Meeting will be on 12th May 2023 in Edinburgh. Organised by Julie Welburn, Andrew Carter and Mark Dodding. Nominal registration fee + green travel subsidies are available.

https://microtubule.bio.ed.ac.uk

#CellBiology #Cytoskeleton #MembraneTraffic

This paper looks at the nanoscale distribution of reticulon 4 relative to curved regions of the ER. Amazing imaging and analysis in here!

https://www.biorxiv.org/content/10.1101/2023.01.26.525608v1

#CellBiology #MembraneTraffic #Microscopy #PreprintOTD

Enjoyable day here at Instituto Gulbenkian de Ciência serving on the PhD jury for Margarida Araújo (Telley + Oliveira labs) who passed with flying colours. Fun project looking at the role of ER in mitotic spindle function in drosophila. You can read her work here:

https://www.life-science-alliance.org/content/6/1/e202201540

#CellBiology #Mitosis #MembraneTraffic

My lab has a #vacancy for a #PostDoc working on a #MembraneTraffic project. It will be of interest to #microscopy people with an interest in neuronal cell biology. Closing 12th Feb.
Boosts appreciated!

https://bit.ly/3GTORvi

https://www.linkedin.com/jobs/view/3433441743/

And so to Mastodon. Exploring use here for #science #research #academia #sciencepolicy #cellbiology #cilia #membranetraffic #membranetraffcking (needs a unified tag!)

Starting again seems good.

Yesterday's UK Membrane Traffic meeting at UCL was great. So nice to be back in-person after a 3 year break. The talks were all interesting from synaptic vesicles, lysosomes, to IFT and array tomography. Talks from ECRs, new PIs, and a grandee in the field.
It's a mature #CellBiology field but there's still lots to discover. It made me really enthusiastic about the future of #membranetraffic.
1/2

I am slightly biased but Méghane just gave a fantastic talk here on vesicle movement in cells #CellBiology #MembraneTraffic