Transdermal & buccal buprenorphine is associated with a small reduction in pain scores in chronic non-cancer pain.
- Kong, 2023 Anesth.Analg. #metaanalysis
→ metajournal.com/36988663

Pharma-Funded Studies More Likely Positive:
Meta-analyses of new cancer drugs and the clinicians conducting them are 2X as likely to report positive results when these studies and authors are funded by the companies making these drugs. #funding #pharma #metaanalysis #credibility
https://www.instagram.com/p/Cw8dE74Rp4K/

Intrathecal fentanyl prolongs post-operative analgesia at the expense of increased incidence of pruritus, but with no increase in respiratory depression.
- Pöpping 2012 Pain #metaanalysis
→ (summary) metajournal.com/22230804

Upper airway complications are no different with desflurane than for sevoflurane, isoflurane or propofol anesthesia when using an LMA.
- Stevanovic 2015 EurJAnaesthesiol #metaanalysis
→ metajournal.com/25545286

Epidural analgesia reduces all-cause mortality after cardiac surgery, at the cost of a 1 in 3,500 risk of epidural hematoma.
- Landoni 2015 BrJAnaesth #metaanalysis
→ metajournal.com/26089444

Statin use is associated with decreased COVID mortality.
- Zein 2022 PostgradMedJ #metaanalysis
→ metajournal.com/34193549

Intrathecal morphine prolongs post-operative analgesia, but at the expense of increasing nausea, vomiting, pruritus, urinary retention and risk of respiratory depression.
- Pöpping 2012 Pain #metaanalysis
→ (summary) metajournal.com/22230804

Both elective (OR 1.47, 1.16-1.86) and emergency (OR 1.53, 1.22-1.91) caesarean section is associated with mild postpartum depression in this network meta-analysis.
- Sun 2021 AustNZJPsychiatry #metaanalysis
→ metajournal.com/32929976

Dexamethasone whether intravenous or perineural prolongs sensory & analgesic blocks more than perineural dexmedetomidine.
- Sehmbi 2021 Anaesthesia #metaanalysis
→ metajournal.com/33118163

Women experience a higher mortality from out-of-hospital cardiac arrest.
- Parikh 2020 Resuscitation #metaanalysis
→ metajournal.com/32810560

Use of quantitative neuromuscular monitoring significantly reduces the incidence of postoperative residual curarisation.
- Carvalho 2020 BrJAnaesth #metaanalysis
→ metajournal.com/32680607

Intraoperative dexamethasone reduces the incidence of postoperative sore throat for up to 24 hours and postoperative hoarseness for 1 hour.
- Zhao 2015 JClinAnesth #metaanalysis
→ metajournal.com/25468585

Neurally-adjusted ventilatory assist improves patient-ventilator synchrony although with uncertain effect on clinical outcome..
- Pettenuzzo 2019 Crit.CareMed. #metaanalysis
→ metajournal.com/30882481

High troponin levels pre-operatively are associated with cardiac events and mortality after non-cardiac surgery.
- Shen 2018 EurJAnaesthesiol #metaanalysis
→ (summary) metajournal.com/30095548

Use of ultrasound guidance for subclavian vein cannulation reduces the incidence of arterial puncture, pneumothorax, and hematoma.
- Lalu 2015 Crit.CareMed. #metaanalysis
→ metajournal.com/25803646

Pulse Pressure Variation and Stroke Volume Variation has limited sensitivity and specificity when assessing the response to intra-operative fluid challenge.
- Messina 2018 Anesth.Analg. #metaanalysis
→ metajournal.com/30300177

Interventions to stiffen the surface during CPR delivery have limited effect on chest compressions in manikin trials.
- Holt 2020 Resuscitation #metaanalysis
→ metajournal.com/32755663

High-risk obstructive sleep apnoea patients identified by STOP-Bang screening suffer higher risk of post-operative adverse events and longer hospital stays.
- Nagappa 2017 Anesth.Analg. #metaanalysis
→ metajournal.com/28817421

Clonidine improves post-operative analgesia, reduces nausea & vomiting, improves hemodynamic stability, does not prolong wakening, and does not improve cardiac outcomes.
- Munoz 2017 JClinAnesth #metaanalysis
→ metajournal.com/28372656

Use of smaller-sized ETT results in less post-operative sore throat in female patients.
- Hu 2013 PlosOne #metaanalysis
→ metajournal.com/24124452