A mitochondrial #EglN1/#PHD2-#AMPK-alpha axis drives #breastcancer progression by enhancing metabolic adaptation to #hypoxic stress

#Hypoxia-induced EglN1-#CaMKK2 interaction on #mitochondrial safeguards AMPKα activation and #metabolic homeostasis during breast cancer growth

https://www.embopress.org/doi/full/10.15252/embj.2023113743

Can #metabolic acquisitions ever become permanent? Here, Alexandra Brown, Grace Casarez, and @mixotrophe apply #adaptiveDynamics to a model of "#chloroplastStealing" #microbes to find out when borrowed machinery is better than having your own.
Read now ahead of print! https://www.journals.uchicago.edu/doi/10.1086/725918

New image-based #cellular profiling tool peers deeply into #metabolic biology.

#microscopy #LipocyteProfiler #genomics

https://phys.org/news/2023-07-image-based-cellular-profiling-tool-peers.html

• Inadequate #sleep is associated with an increased risk of #metabolic disorders.
• Mitochondrial metabolism lies at the heart of a homeostatic sleep-regulatory mechanism.
• Sleep need is encoded in the excitability state of sleep-control neurons in the central fly brain.
• #Mitochondrial ROS promotes sleep by acting on a redox-sensitive potassium channel subunit.
• Mitochondrial ROS modulates the activity of sleep-control #neurons
https://www.sciencedirect.com/science/article/pii/S0959438823000582

Metabolic associated fatty liver's on the rise
Though in genetics, obesity's the surprise
It's not just these two playing the game
For diet and lifestyle share the blame
What was once uncommon is now the norm
The earlier we take action, the better the form

#metabolic #fattyliver #obesity #lifestyle #health #prevention #poetry

http://www.medicalnewstoday.com/articles/why-metabolic-associated-fatty-liver-disease-is-on-the-rise

If you haven't heard, @poconnor is donating half of her profits from "Living with PKU" to the NSPKU - a fantastic charity that helps people with the rare disorder called PKU!

And if you buy both of her books, you get 25% off!

Get her books here now:

https://pigpen.page/books/

Also, please boost! Boosts are incredibly welcome!!

#phenyketonuria #phenylcetonurie #phenylalanine #book #books #bookstodon #pku #metabolic #metabolicdiet #metabolicdisease

Just noticed @poconnor has made a new blog - and it contains her utterly fantastic new graphic that explains how PKU is passed on from parents!

Give it a read here on her blog:

https://pigpen.page/the-genetics-of-pku/

#pigpen #phenyketonuria #pku #phenylalnine #genetics #health #metabolic #metabolicdiet #metabolicdisease #dna #sapropterin

How can #metabolic & #environmental cues modulate the #DNAdamage response? María Moriel-Carretero et al find master kinase #Tel1/ATM to bind #PI4P at the #Golgi, altering its availability in the nucleus and impacting kinetics, intensity and persistence of DNA DSB responses in yeast and human cells

#RefereedPreprint c/o @ReviewCommons

https://www.embopress.org/doi/10.15252/embj.2022112684

A question to the PKU community:

What would you say to parents who have just discovered that their child has PKU?

#pku #phenylketonuria #parenting #parents #lowprotein #metabolic #phenylcetonurie #phenylalanine

Me as a child whenever I had to drink Maximaid in public

#pku #phenylketonuria #lowprotein #metabolicdiet #metabolic

Our findings establish a pivotal role of #intestine clock in dictating liver rhythmicity and diurnal #metabolism, and suggest targeting intestinal rhythms as a new avenue for improving #metabolic health.
https://www.sciencedirect.com/science/article/abs/pii/S0168827823003392

First it was #bariatric or weight loss #surgery. Then it became #metabolic and bariatric surgery. Maybe it's time to drop the confusing "bariatric" label. Because metabolic surgery has an enduring role to play in #ObesityCare.
https://conscienhealth.org/2023/05/goodbye-bariatric-hello-metabolic-surgery/

Sun et al. provide a comprehensive perspective of the #cellular landscape during #soybean #nodulation, shedding light on the #metabolic and #developmental mechanisms of #nodule formation.
https://doi.org/10.1111/jipb.13495.
@wileyplantsci
#JIPB #PlantScience #NitrogenFixation

Greater #duckweed shows #metabolic flexibility during #trophic #transition.

#carboncapture #mixotrophic #proteomics #metabolomics

https://phys.org/news/2023-04-greater-duckweed-metabolic-flexibility-trophic.html

RT @NatureMedicine
Integrated analyses reveal that multiomics captured the heterogeneity of #metabolic states accompanying #obesity and changes in metabolic health in response to #lifestyle intervention which are not apparent in #BMI measurements. @nrappapo @isbsci
https://www.nature.com/articles/s41591-023-02248-0

In hot water: Ocean #warming impacts growth, #metabolic rate and #gene activity of newly hatched #clownfish.

#conservation #climatechange

https://phys.org/news/2023-03-hot-ocean-impacts-growth-metabolic.html

Highlighted in issue 6: #Phytosulfokine balancing growth and defense in #plants

Reviews on HIF regulation of #metabolic crosstalk in tumor #microenvironment, and #evolutionary origins of #auxin responses

Further:
Phase separation of #Hippo signalling complexes
#Mitochondrial oxidative stress checkpoint via DNA-PKcs and ATM

Cover by @tatsuofukagawa1 and colleagues

https://www.embopress.org/toc/14602075/2023/42/6

📢Out Now in OA: 'Introduction to #Systems #Biology: #Workbook for Flipped-classroom Teaching' by Thomas Sauter and Marco Albrecht.

This book is an introduction to the language of systems biology, which is spoken among many disciplines, from biology to #engineering.

Authors Thomas Sauter and Marco Albrecht draw on a multidisciplinary background and evidence-based learning to facilitate the understanding of #biochemical networks, #metabolic modeling and system dynamics.

Their #pedagogic approach briefly highlights core ideas of concepts in a broader interdisciplinary framework to guide a more effective deep dive thereafter.

The learning journey starts with the purity of #mathematical concepts, reveals its power to connect biological entities in structure and time, and finally introduces #physics concepts to tightly align abstraction with reality. (5/9)

Access this OA title for free or get a hard copy at https://openbookpublishers.com/books/10.11647/obp.0291
👇🧵(1/9)

#Metal contamination causes #metabolic #stress in environmental #bacteria, shows study.

https://phys.org/news/2023-03-metal-contamination-metabolic-stress-environmental.html

I somehow missed Rare Disease Day yesterday, 28th February, which is a bit of a faux pas for a carrier of a rare disease gene (Classic PKU) and a dad to a kid with PKU. I wouldn’t have missed it on the Other Site. Isolated communities excel at using Twitter to cohere around spotlight days or months. But in good news today I’ve found two other Mastodonians using the PKU #. Our rare community just grew a little. #RareDisease #RareDiseaseDay #PKU #phenylketonuria #Metabolic #PKUlife