Small but mighty: Sneider and colleagues demonstrate the impact of tissue stiffness on extracellular vesicle-mediated metastasis in breast cancer. #WirtzLab #preprint

Great team effort from preLighters Jade Chan & Yohalie Kalukula – check it out! 👀

#preLight 👉 https://prelights.biologists.com/highlights/small-extracellular-vesicles-promote-stiffness-mediated-metastasis/

#ECM #EVs #metastasis #Cancer

A large problem in treating #cancer is that tumor cells can break loose and travel through the body, founding new tumors. This is known as #metastasis. A single tumor can usually be operated, but when they start growing all over, the cancer becomes very hard to fight.

Scientists have now uncovered a part of the mechanism that makes those tumor cells travel. There's a #protein known as #GRP78 that normally hangs out in a part of the cell called the endoplasmatic reticulum, where it helps large proteins to fold the right way. However, when the cell is under stress, or becomes cancerous, GRP78 can travel to the cell's nucleus and turn certain #genes on and off. Several of those genes control the cell's willingness to travel.

This discovery opens up new avenues of #research and possible treatments.

https://medicalxpress.com/news/2023-07-unexpected-mechanism-cancer-cell.html

#Magnesium #whitlockite formation in the alveolar #bone, with #bisphosphonate exposure and osteolytic #skeletal #metastasis. Scanning electron microscopy, Micro-Raman spectroscopy, and energy dispersive X-ray spectroscopy reveal Mg-rich, rhomboidal nodules (200 nm to 2.4 µm) within the lacuno-canalicular space. Mg-whitlockite formation in #osteocyte lacunae is multifactorial in #nature and suggests altered bone #biomineralization.

Read more:
https://doi.org/10.1016/j.micron.2023.103441

#biology #pathology #science

Nicotine Associated with Breast Cancer Spread: Best Of: 1/2021:
North Carolina oncologists report that former or current cigarette smokers are significantly more likely to suffer breast cancer lung metastases compared with non-smokers. #breastcancer #metastasis #nicotine
https://youtu.be/Knip3Vws2AY

Two positions: 1. Director of Imaging Applications 2. Imaging Specialist @dentenberg

Come join us in NYC and make an impact on cancer research!

https://jobrxiv.org/job/einstein-college-of-medicine-27778-two-positions-1-director-of-imaging-applications-2-imaging-specialist/?feed_id=40722

#ScienceJobs #job #imaging, #microscopy, #metastasis, #cancerresearch
Bronx, ...
https://jobrxiv.org/job/einstein-college-of-medicine-27778-two-positions-1-director-of-imaging-applications-2-imaging-specialist/?feed_id=40722

#Metastatic #cancercells find ways to thrive in harsh environments. #StJude #scientists have new clues about how those #cells succeed and how to potentially stop them. “The overarching goal of our lab is to understand how #metastasis works so that we can eventually target it therapeutically,” says Dr. Myriam Labelle of #Oncology. Learn more. http://bit.ly/3ZUjLvN #StJudeResearch #WomenInScience #WHM

#Magnesium #whitlockite formation in the alveolar #bone, with #bisphosphonate exposure and #osteolytic #skeletal #metastasis. Scanning electron microscopy, Micro-Raman spectroscopy, and energy dispersive X-ray spectroscopy revealed Mg-rich, rhomboidal nodules (~200 nm to ~2.4 µm) within the lacuno-canalicular space. Mg-whitlockite formation within #osteocyte lacunae is multifactorial in #nature and suggests altered bone #biomineralization.

Read more:
https://doi.org/10.1016/j.micron.2023.103441

#biology #pathology

We are hiring! @INCITeCentre is growing and we are looking for talent to join our team to look into the dark space of tumours. Please DM for more info. Please RT 🙏
---
RT @INCITeCentre
🚨 JOB ALERT🚨 Interested in working on #tumor #metastasis, #cancer cell #dormancy, #autoimmunity and using high resolution #imaging? Apply to us! #recruiting #intravital #INCITe
@LabPhan @Timpson_Lab @GarvanInstitute
DM if interested!

https://www.natu…
https://twitter.com/INCITeCentre/status/1632876999151865861

Two positions: 1. Director of Imaging Applications 2. Imaging Specialist @dentenberg

Come join us in NYC and make an impact on cancer research!

https://jobrxiv.org/job/einstein-college-of-medicine-27778-two-positions-1-director-of-imaging-applications-2-imaging-specialist/?feed_id=38994

#ScienceJobs #job #imaging, #microscopy, #metastasis, #cancerresearch
Bronx, ...
https://jobrxiv.org/job/einstein-college-of-medicine-27778-two-positions-1-director-of-imaging-applications-2-imaging-specialist/?feed_id=38994

RT @JInsuaRodriguez
We are looking for a new member for the Early Career Leadership Council of the MRS!

If you're an early/mid career scientist/clinician and want to be part of a dynamic international team committed to #metastasis research, apply! https://twitter.com/MetastasisRS/status/1628018385123434504

Beug Foundation’s Prize for Metastasis Research opened their 2023 call: young scientists are invited to apply with an original project on #cancer #metastasis #research in Europe. Join the many outstanding awardees selected since 2011!
👉🏽 https://www.beugstiftung-metastase.de/apply-now/

RT from the fabulous Ana Correia @alpcorreia

Thrilled to share my Perspective on how #TissueImmunity selectively restrains the growth of metastases - an exciting avenue for developing #Immunotherapies for long-lasting control of #Metastasis
Thanks Lucy Bird and @NatRevImmunol for the opportunity!
👉rdcu.be/c4539

RT @emiliocasanova9
Call for applications for the Beug Foundation’s Prize for Metastasis Research 2023. #cancer #metastasis #prize
Apply here
https://www.beugstiftung-metastase.de
Please, RT

Iris Lähdeniemi and Jennifer Devlin develop a reproducible and rapid tumour-lung colonisation model to study an aggressive subset of non-small cell lung #cancer (NSCLC):

https://journals.biologists.com/bio/article/11/12/bio059623/285932/Development-of-an-adenosquamous-carcinoma

#NSCLC #Carcinoma #Histopathology #Metastasis #PreclinicalModel #Science #BiologyOpen #Biology #AcademicMastodon

Stopping Breast Cancer Spread:
Israeli researchers have shown that malignant cells penetrate blood vessels with micro drills they call invadopodia. Now discovery of a peptide protein that blocks invadopodia formation. #breastcancer #metastasis #invadopodia #pyk2 #coractin
https://youtu.be/HJqsTYYKtI0

A new target to stop about 90% of cancer deaths (preventing #metastasis) was found with immunodeficient #mice. Potential research opportunities are opened to slow or stop cells.

https://scitechdaily.com/new-study-uncovers-potential-target-for-stopping-90-of-cancer-deaths/

A new target to stop about 90% of cancer deaths (preventing #metastasis) was found with immunodeficient #mice. Potential research opportunities are opened to slow or stop cells.

https://scitechdaily.com/new-study-uncovers-potential-target-for-stopping-90-of-cancer-deaths/

RT @rio_sugimura: RT @Lo_Zanzi@twitter.com

#ImmunometabolismPower! Beta-glucans induce training of #lung interstitial macrophages via increased S1P sphingolipid induction (no mTOR or HIF1a invol), #mitochodrial fragmentation/ROS production & protects against lung #tumor #metastasis! @NatImmunol@twitter.com http://doi.org/10.1038/s41590-022-01388-8

🐦🔗: https://twitter.com/Lo_Zanzi/status/1612451544485531648

#oncology

In a new study from Yale Cancer Center, Don Nguyen, PhD, says #laminin produced by blood vessels in the brain may help #cancer cells form #metastasis and evade treatment. Researchers found residual #tumor cells remain even with good drug penetration. #medtwitter
https://medicine.yale.edu/news-article/yale-cancer-center-study-characterizes-link-between-drug-resistance-and-central-nervous-system-relapse/

RT @mathoncoblog@twitter.com

Likely our last blog post this year. Here Saumil Shah working with @EvolTheoArne@twitter.com and @_michael_raatz@twitter.com describe the latest work using #mathonco to explore how #plasticity impacts #metastasis and treatment:
https://mathematical-oncology.org/blog/phenotypic-plasticity.html

🐦🔗: https://twitter.com/mathoncoblog/status/1605150984417714176