DNA sensing via the #cGAS/STING pathway regulates #immunoproteasome function and #MHC class I #antigen presentation to promote #Tcell activation - with implications for the pathology of idiopathic pulmonary fibrosis
Silke Meiners et al ForschungszentrumBorstel@norden.social
#cgas #immunoproteasome #mhc #antigen #Tcell
Great thread by @jeffgilchrist explaining some basic immunology and how newer COVID strains hijack it — with invisibility glamours and look-away spells. (Those are my words. He’s very scientific.)
https://mstdn.science/@jeffgilchrist/109642512693828283
#COVID19 #Covid #ImmuneEvasion #MHC #NKCells #NaturalKillerCells
#COVID19 #covid #immuneevasion #mhc #nkcells #naturalkillercells
How #COVID actively suppresses and evades your #immune system [Part 1]
This thread highlights multiple methods that the virus uses to help keep #reinfecting people including #MHC-I and #interferon #suppression, #evasion of Natural Killer (NK) cells, and reprogramming of #monocytes. 🧵 1/
The one page web view is available here: https://pingthread.com/thread/1611333222419566594
#covid #immune #reinfecting #mhc #Interferon #suppression #evasion #monocytes
prof Akiko Iwasaki 💫
#MHC-I
#downregulation by #SarsCov2
⬇️
https://threadreaderapp.com/thread/1607446922599763968.html
😷
#mhc #downregulation #SarsCoV2 #immunology #mechanism
More science about Covid’s strategies for evading immune detection.
Preprint here: https://www.biorxiv.org/content/10.1101/2022.05.04.490614v3
#Covid #COVID19 #MHC #CD8TCells #InnateImmunity #Immune system
#covid #COVID19 #mhc #cd8tcells #innateimmunity #immune
I am done with lab work (celebrating w new do) for my Marie Curie project @msca on #hybrids and #MHC in #marmosets. Now 💻. COVID almost destroyed this but even finishing a year after funds ran out I am determined to reach my goals. Thank you @dpz_eu @marissa_lima @estercsabino
No evidence for link between #complement C4 and #schizophrenia!
An impressive #medRXiv study in ~70k blood samples fails to detect association between #C4 genes and protein at birth and schziophrenia later in life. This is interesting because the strongest genome-wide association for #schizophrenia, found in the #MHC region, has so far been attributed to C4. May the search for other loci continue, I cannot wait to see the #GWAS mystery of schizophrenia unfold!
https://www.medrxiv.org/content/10.1101/2022.11.09.22281216v1
#complement #schizophrenia #medrxiv #c4 #mhc #gwas
20. #Todestag - Am 29. September 2002 starb in #Berlin der #Historiker, #Publizist und #Schwulen-#Aktivist Hans-Georg #stümke (auch bekannt als Elvira #Klöppelschuh )
#UHA #mhc #Schwulenbewegung
https://www.2mecs.de/wp/2009/09/hans-georg-stuemke/
#todestag #berlin #historiker #publizist #schwulen #aktivist #stümke #Klöppelschuh #UHA #mhc #schwulenbewegung