we demonstrated that all #SARSCoV2 #VOCs possess the ability to suppress #MHCI expression.

MHC-I upregulation was strongly inhibited after SARS-CoV-2 but not influenza virus infection

#Omicron subvariants showed an enhanced ability to suppress MHC-I compared to the original strain & the earlier SARS-CoV-2 VOCs

inherently strong ability of SARS-CoV-2 to hinder MHC-I expression & demonstrated that Omicron subvariants have evolved an even more optimized capacity to evade CD8 T cell recognition.