The EMBO Journal · @embojournal
439 followers · 156 posts · Server sciencemastodon.com
A #CRISPR-Cas9-tagging approach to induce #chromosome-specific segmental #aneuploidies: targeted assembly of ectopic #kinetochores at endogenous repeats - a way to recapitulate and study specific disease-associated #missegregation events in human cells
@McClellandLab
https://www.embopress.org/doi/10.15252/embj.2022111587
#crispr #Chromosome #aneuploidies #kinetochores #missegregation
The EMBO Journal · @embojournal
432 followers · 154 posts · Server sciencemastodon.com
How do cancer-specific chromosome gains/losses contribute to #oncogenesis?
Susanne Lens and collaborators at UMC Utrecht describe a #kinesin-based strategy for inducing #mitotic #missegregation of selected #chromosomes, as tool for modeling specific #aneuploidies
#oncogenesis #kinesin #mitotic #missegregation #Chromosomes #aneuploidies
The EMBO Journal · @embojournal
301 followers · 37 posts · Server sciencemastodon.com
How do #yeast cells adapt to high rates of #chromosome #missegregation?
Chris Campbell and coworkers @maxperutzlabs define serial alterations from specific #aneuploidies, #karyotype refinement, point #mutations, to loss of beneficial copy number alterations
#yeast #Chromosome #missegregation #aneuploidies #karyotype #Mutations