This weeks early bird @biomednews issues on #mitochondria #cancer #muscle #myotwitter #er_literature. Find the full list of reports and subscribe at http://biomed.news/reports

This weeks first @biomednews reporters. Reports on #cancer #mitochondria #muscle. See the others at http://Biomed.news/reports

Unprecedented nanometer-scale structures of cristae in >400 individual #mitochondria, by @Hirabayashi_Lab, using a novel deep learning-based analysis of #volumeEM images, (also reveals previously unknown function of OPA1) #PLOSBiology https://plos.io/3OXtPzK

#IDMastodon #CellImmunity #Viralimmunology #CovidIsNotOver #MaskUp 😷 Host #mitochondria more than an organelle in #SARSCoV2 infection . when 🦠 hijacks mitochondrial function, this allows it to control the entire cell.Emerging evidence suggested that #SARSCoV2 hijacks the mitochondria of immune cells, proliferate in mitochondrial structures & impairs mitochondrial functions . The interaction of several #SARSCoV2 proteins with mitochondrial components components may occur.

#IDMastodon #Immunology @nih_nhlbi #CovidIsNotOver #WearAMask😷 #getvaccinated #SARSCoV2, 🦠 that causes #COVID19 can cause lasting damage to energy production by #mitochondria in many organs of the body.Stopping the virus from hijacking mitochondrial energy production may be a novel way to prevent serious complications from #SarsCoV2 infection.
https://www.nih.gov/news-events/nih-research-matters/sars-cov-2-can-cause-lasting-damage-cells-energy-production

Why do individuals respond differently to dietary changes? A new #PLOSBiology study shows how #genetic differences in #mitochondria and the nucleus in #Drosophila interact to determine fitness response to #dietary manipulation.
https://plos.io/3OO3eVR

“So electrical membrane potential has a dynamic range, singing like a string on a violin. Electrical fields resonate out from the membrane, capturing the nearby jostling crowd of molecules in an oscillating dance.”

— Nick Lane, Transformer

📖 #AmReading #Bookstodon #Nonfiction #Science #Metabolism #Mitochondria

Mitochondria, the cell's powerhouses, may hold the key to preventing Alzheimer’s disease. Damaged mitochondria are linked to the progression of Alzheimer’s, and how healthy mitochondria can protect the brain from cognitive decline. There are some simple ways to support mitochondrial function, such as exercise and antioxidants, that could benefit memory and overall health. #Mitochondria #Alzheimers #BrainHealth https://bigthink.com/neuropsych/stave-off-alzheimers-protect-brain-mitochondria/

Miro GTPases mediate mitochondrial attachment to motor proteins. @framattedi @alessio_vagnoni &co use photocleavable #Miro to inactivate it in fly neurons, revealing immediate consequences of its loss for #mitochondria, neurons & behavior #PLOSBiology https://plos.io/3seG2bE

#Mitochondria are in a constant flux of fusion & fission, but how to prevent excessive fission? This study shows that the conserved AAA-ATPase Yta4 interacts with the mitochondrial #divisome (Fis1, Mdv1, Dnm1) to inhibit mitochondrial fission #PLOSBiology https://plos.io/3DXUvLP

"Endoplamic reticulum stress–induced #WASF3 protein localizes to #mitochondria and disrupts respiratory supercomplex assembly, leading to decreased oxygen consumption and exercise endurance. Alleviating ER stress decreases WASF3 and restores mitochondrial function, indicating that WASF3 can impair skeletal muscle #bioenergetics and may be targetable for treating #fatigue symptoms."

#MECFS #PostCovid #LongCovid #Science

https://www.pnas.org/doi/10.1073/pnas.2302738120

#IDMastodon #LongCovid #mitochondria the Big Miss, and Hope by @erictopol
https://erictopol.substack.com/p/long-covid-mitochondria-the-big-miss

The Lady of the Lithuanian buttplug gave me Dr. Jack Kruse. He's a dentist, brain surgeon and now fully engulfed into the workings of #mitochondria. This episode he is interviewed by a doctor from #Australia 🇦🇺 🦘 and he explains what it is they're doing wrong. Uncle Jack explains that UV-light is not the enemy. Blue light is. And exposure to it is epidemic. We should be out in the sun. Consider the 3:24'42" as background sound. Difficult, but still educational.
https://youtu.be/Ln3WszTq0uA?t=10230

Sjögren KG, Olalde I, Carver S, Allentoft ME, Knowles T, et al. (2020) Kinship and social organization in Copper Age Europe. A cross-disciplinary analysis of archaeology, DNA, isotopes, and anthropology from two Bell Beaker cemeteries. PLOS ONE 15(11): e0241278. https://doi.org/10.1371/journal.pone.0241278 #OpenAccess #OA #Research #Article #Haplotypes #Mitochondria #Human #HumanGenetics #Genetics #Archaeology #Europe #Anthropology #Culture #Science @science @archaeodons @anthropology

Kinship and social organization in Copper Age Europe. A cross-disciplinary analysis of archaeology, DNA, isotopes, and anthropology from two Bell Beaker cemeteries
Sjögren KG, Olalde I, Carver S, Allentoft ME, Knowles T, et al. (2020) Kinship and social organization in Copper Age Europe. A cross-disciplinary analysis of archaeology, DNA, isotopes, and anthropology from two Bell Beaker cemeteries. PLOS ONE 15(11): e0241278. https://doi.org/10.1371/journal.pone.0241278 #OpenAccess #OA #Research #Article #Haplotypes #Mitochondria #Human #HumanGenetics #Genetics #Archaeology #Europe #Anthropology #Culture #Science @science @archaeodons @anthropology

'While extensive research has focused on mitochondrial dNTP homeostasis due to its defects being associated with various mitochondrial DNA (mtDNA) depletion and deletion syndromes, the investigation of mitochondrial rNTP homeostasis has received relatively little attention.'
#mitochondria

https://www.embopress.org/doi/full/10.15252/embj.2023114990

Profiling the mitochondrial nucleoid mystery protein C17orf80
https://journals.biologists.com/jcs/article/136/15/e136_e1501/325735/Profiling-the-mitochondrial-nucleoid-mystery

Check out the first Research Highlight from issue 15 of JCS!
Johannes Spelbrink and colleagues explore the uncharacterised nucleoid-associated protein C17orf80, which despite showing genetic associations with cancer and autism spectrum disorder, does not yet have a clear molecular function.
#mitochondria #cellbiology

Alisa Potter, Johannes Spelbrink and colleagues discover that C17orf80 is a mitochondrial membrane-associated protein that interacts with nucleoids.

Highlight: https://journals.biologists.com/jcs/article/136/15/e136_e1501/325735/Profiling-the-mitochondrial-nucleoid-mystery

#OpenAccess Article: https://journals.biologists.com/jcs/article/136/15/jcs260822/324980/Uncharacterized-protein-C17orf80-a-novel

#CellBiology #mitochondria

Fibroblast mitochondria fuel power-hungry cancer cells
https://journals.biologists.com/jcs/article/136/14/e136_e1403/324880/Fibroblast-mitochondria-fuel-power-hungry-cancer

Sharing the last Research Highlight for JCS Issue 14: Cynthia Reinhart-King and colleagues explore the relationship between invasive phenotypes in aggressive breast cancer cells and mitochondrial transfer from cancer-associated fibroblasts. Check out their findings on this 'metabolic symbiosis' that might drive tumor invasion.
#mitochondria #cancerbio #breastcancer

New #ISEPpapers! The free-living flagellate #Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools: Justyna Zítek et al. https://www.sciencedirect.com/science/article/pii/S0003986123001376 #protists #mitochondria #evolution #eukaryotes #microbes #anaerobes #nucleotides