Sophie Dumont at UCSF
http://www.dumontlab.ucsf.edu/

#Chromosome size alters #kinetochore attachment stability and alignment order in mammalian #mitosis

Lab interested in #SelfOrganization and emergent mechanics across scales.... "biological structures build themselves" using only local cues they get global information. mitotic spindle a great example

kinetochores attach, sense tension, can make mistakes which are corrected. how does this work when chromosomes vary in size?

#CSSingleCells23

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Happy Monday, #ScienceMastodon! The newest Research Highlight from JCS features a paper from Juan Martin-Serrano and colleagues at King's College London identifying UMAD1 as a novel component of the ESCRT-I membrane remodeling complex during cytokinetic abscission. Check it out here:

UMAD1 helps ESCRT machinery sever ties during abscission

https://journals.biologists.com/jcs/article/136/15/e136_e1503/325852/UMAD1-helps-ESCRT-machinery-sever-ties-during
#mitosis #membranes #CellBiology

@catsalad
I just discovered (as a result of this) that I can represent #Mitosis using archaic #Cyrillic #unicode:
(G) О -> (prophase) Ꙩ-> (Metaphase) Ꙫ-> (Telophase) Ꙭ -> ꙨꙨ (Cytokinesis)

📰 "1,3,4-Oxadiazoles as Anticancer Agents: A Review"
by 🔬 Greesh Kumar, Rajnish Kumar, Avijit Mazumder, None Salahuddin, Upendra Kumar
https://pubmed.ncbi.nlm.nih.gov/37497702/ #Mitosis #Cell

📰 "Anti-tumor and cardiotoxic effects of microtubule polymerization inhibitors: The mechanisms and management strategies"
by 🔬 Ryota Tochinai, Yoshiyasu Nagashima, Shin-Ichi Sekizawa, Masayoshi Kuwahara
https://pubmed.ncbi.nlm.nih.gov/37496236/ #Microtubule #Mitosis

Zooming across time and space simultaneously with #superresolution to understand how #cells #divide.

#mitosis #PINE #nanoscopy

https://theconversation.com/zooming-across-time-and-space-simultaneously-with-superresolution-to-understand-how-cells-divide-203324

📰 "A multistage Plasmodium CRL4-WIG1 ubiquitin ligase is critical for the formation of functional microtubule organisation centres in microgametocytes"
by 🔬 Rashpa, R., Smith, C., Artavanis-Tsakonas, K., Brochet, M.
http://biorxiv.org/content/10.1101/2023.07.19.549332v1?rss=1 #Microtubule #Mitosis

📰 "TBP facilitates RNA Polymerase I transcription following mitosis"
by 🔬 Kwan, J. Z. J., Nguyen, T. F., Teves, S. S.
http://biorxiv.org/content/10.1101/2023.07.13.548763v1?rss=1 #Mitosis #Cell

📰 "A potential posttranscriptional regulator for p60-katanin: miR-124-3p"
by 🔬 Yesim Kaya, Sirin Korulu, Ezgi Nurdan Yenilmez Tunoglu, Aysegul Yildiz
https://pubmed.ncbi.nlm.nih.gov/37439368/ #Microtubule #Mitosis

📰 "Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway"
by 🔬 Diane Pelzer, Ludmilla de Plater, Peta Bradbury, Adrien Eichmuller, Anne Bourdais, Guillaume Halet, Jean-Léon Maître
https://pubmed.ncbi.nlm.nih.gov/37427462/ #Mitosis #Cell

📰 "RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells"
by 🔬 Ivor Joseph, Juan Flores, Victoria Farrell, Justin Davis, Jared Bianchi-Smak, Qiang Feng, Sayantani Goswami, Xiang Lin, Zhi Wei, Kevin Tong, Zhaohui Feng, Michael P Verzi, Edward M Bonder et al.
https://pubmed.ncbi.nlm.nih.gov/37424454/ #Mitosis #Cell

📰 "Mon1a and FCHO2 are required for maintenance of Golgi architecture"
by 🔬 Bagley, D. C., Morham, S. G., Kaplan, J., Ward, D. M.
http://biorxiv.org/content/10.1101/2023.07.06.547837v1?rss=1 #Mitosis #Cell

📰 "BRD4 directs mitotic cell division by inhibiting DNA damage"
by 🔬 Ozato, K., Wu, T., Hou, H., Dey, A., Bachu, M., Chen, X., Wisniewski, J., Kudoh, F., Chen, C., Chauhan, S., Xiao, H., Pan, R.
http://biorxiv.org/content/10.1101/2023.07.02.547436v1?rss=1 #CellDivision #Mitosis #Cell

📰 "Implantable, Biodegradable, and Wireless Triboelectric Devices for Cancer Therapy Through Disrupting Microtubule and Actins Dynamics"
by 🔬 Shuncheng Yao, Shaobo Wang, Minjia Zheng, Zhuo Wang, Zhirong Liu, Zhong Lin Wang, Linlin Li
https://pubmed.ncbi.nlm.nih.gov/37392034/ #Microtubule #Dynamics #Mitosis #Cell

📰 "Mechanical coupling coordinates microtubule growth"
by 🔬 Leeds, B. K., Kostello, K. F., Liu, Y. Y., Biggins, S., Asbury, C. L.
http://biorxiv.org/content/10.1101/2023.06.29.547092v1?rss=1 #Microtubule #Mechanical #Mitosis

#Introduction (just moved to new instance)

I am a cell biologist running a research group (@roylelab) focused on membrane traffic and cell division in human cells. My lab is in @Warwick_CMCB at #WarwickUni. My posts are mainly about #science and #CellBiology but also #music, #running and #cycling.

My previous handle was clathrin. For my data analysis alter-ego, follow @quantixed.

#Microscopy #ImageAnalysis #MembraneTraffic #Mitosis #OpenScience #RStats

📰 "Stable expression and multi-site location of Odf2 in mouse oocytes, sperm and early embryos"
by 🔬 Xiangning Xu, Xiuying Jiang, Ke Song, Jiaqi Zhang, Ying Tian, Ye Chen, Jing Weng, Yuanjing Liang, Wei Ma
https://pubmed.ncbi.nlm.nih.gov/37364712/ #Microtubule #Mitosis

📰 "Tubulin degradation: Principles, agents, and applications"
by 🔬 Yi-Fan Zhang, Jiao Huang, Wei-Xin Zhang, Yun-He Liu, Xiao Wang, Jian Song, Cheng-Yun Jin, Sai-Yang Zhang
https://pubmed.ncbi.nlm.nih.gov/37356337/ #Microtubule #Mitosis

📰 "ER-Mitochondria Contact Sites expand during mitosis"
by 🔬 Yu, F., Courjaret, R., Elmi, A., Hammad, A. S., Fisher, M., Terasaki, M., Machaca, K.
http://biorxiv.org/content/10.1101/2023.06.22.546089v1?rss=1 #Mitosis #Cell

📰 "Interdependence of a microtubule polymerase and a motor protein in establishment of kinetochore end-on attachments"
by 🔬 Julia R Torvi, Jonathan Wong, David G Drubin, Georjana Barnes
https://pubmed.ncbi.nlm.nih.gov/37333421/ #Microtubule #Mitosis