Very exciting that this paper is out now in #cancercell: https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00216-7

In brief: we show that in esophageal #adenocarcinoma #checkpoint #therapy success is predicted by an independent combination of mutation burden and the amount of #monocytes in the tumour pre-treatment (as measured by RNAseq). Very exciting link between #myeloid cells and #immune response to #cancer!

Greater Manchester researchers have shown that malfunctioning behaviour of a type of immune cell is linked to specific symptoms of long Covid.
#Bylines #LongCovid #Monocytes
https://northwestbylines.co.uk/news/health/covid/malfunctioning-immune-cell-behaviour-could-be-drug-target-in-long-covid/

#Innate and #Adaptive #Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms
#COVID19 #Bcells #neutrophils #dendritic_cells #Tcells #NKcells #monocytes #macrophages #SARSCoV2
https://www.mdpi.com/2076-393X/11/2/408

RT @jeffgilchrist
How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

Second great thread from @jeffgilchrist explaining ways Covid gets around our immune system’s. Here he describes how it shifts monocytes from their protective function to one that leads to more clotting. And, the virus basically grows your nasal cilia like jack and the bean stock (his analogy) to bypass protective mucus.

Fascinating and gnarly.

https://mstdn.science/@jeffgilchrist/109654329276913147

#Covid #COVID19 #Monocytes #ImmuneEvasion #CovidIsNotOver

Second great thread from @jeffgilchrist explaining ways Covid gets around our immune system’s. Here he describes how it shifts monocytes from their protective function to one that leads to more clotting. And, the virus basically grows your nasal cilia like jack and the bean stock (his analogy) to bypass protective mucus.

Fascinating and gnarly.

https://mstdn.science/@jeffgilchrist/109654329276913147

#Covid #COVID19 #Monocytes #ImmuneEvasion are #CoveItIsNotOver

The paper focuses on #DendriticCells (DC) and #monocytes from a local inflammatory site, in this case synovial fluid from swollen joints of mainly juvenile #arthritis patients.
Very short: one type of DC were very much enriched but seemed relatively quiescent despite the inflammatory surroundings, while other DC and monocytes behaved clearly pro-inflammatory.

Last week, the paper based on my work in the Wilhelmina Children's Hospital (WKZ) was published, with the title "Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis".
https://doi.org/10.3389/fimmu.2022.1101999

Credits to Anoushka Samat for taking care of this after I left the department. Without her this work would not be out there. And of course thanks to the rest of the team.

#immunology #RNAseq #inflammation #DendriticCells #monocytes

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/ https://t.co/pOgVsrG4yX

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

RT @jeffgilchrist
How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose 🧵 1/

The one page web view is also available here: https://pingthread.com/thread/1612066649934290946

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946

RT @jeffgilchrist@twitter.com

How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/ https://t.co/pOgVsrG4yX

🐦🔗: https://twitter.com/jeffgilchrist/status/1612066649934290946