"Is there a recent review of the #morphogen control of tissue patterning that I can read on my summer hols?" I hear you ask

Why, yes, there is. Here's @AKicheva & my summary of the current state of the field & open questions

https://www.annualreviews.org/doi/10.1146/annurev-cellbio-020823-011522?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

A thoughtful review on how Dpp/BMP functions as a #morphogen in the #Drosophila wing to control growth and patterning. There is still much to learn!
#DevBio
https://doi.org/10.1002/bies.202200218

RT @DagmarIber
How to achieve high #patterning #precision in #development?

#Morphogen gradients are more precise in #2D than in 1D, in particular when #cells are #narrow.

Check out our latest #preprint on @biorxivpreprint: https://doi.org/10.1101/2023.03.13.532369

RT @DagmarIber
How to achieve high #patterning #precision in #development?

#Morphogen gradients are more precise in #2D than in 1D, in particular when #cells are #narrow.

Check out our latest #preprint on @biorxivpreprint: https://doi.org/10.1101/2023.03.13.532369

RT @DagmarIber
How to achieve high #patterning #precision in #development?

#Morphogen gradients are more precise in #2D than in 1D, in particular when #cells are #narrow.

Check out our latest #preprint on @biorxivpreprint: https://doi.org/10.1101/2023.03.13.532369

Our paper builds on previous work from our group that

- introduced the 1D morphogen gradient model:
https://twitter.com/DagmarIber/status/1499631526056796162

- revealed the impact of cell size on patterning precision:
https://twitter.com/DagmarIber/status/1489479705292156933

- explored the effect of non-linear decay:

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RT @DagmarIber
Does self-enhanced #morphogen #degradation improve #patterning #precision in #tissue #development? …
https://twitter.com/DagmarIber/status/1589511772285054976

The #positional #error of a #morphogen #gradient significantly decreases as the patterned #tissue widens. It can drop from above one #cell diameter to below half a cell diameter, before saturating at a #tissue width beyond about 10 cells.

How to achieve high #patterning #precision in #development?

#Morphogen gradients are more precise in #2D than in 1D, in particular when #cells are #narrow.

Check out our latest #preprint on @biorxivpreprint: https://doi.org/10.1101/2023.03.13.532369

Study shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO

Study shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO

Study shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO

RT @DagmarIber
How does #cell size affect #patterning precision in the #embryo?

A novel cell-based simulation framework reveals the impact of cell diameter on #morphogen gradient variability in #tissue #development.

Check out our latest pre-print: https://www.biorxiv.org/content/10.1101/2022.02.02.478800v1

🧵 (1/6)

RT @DagmarIber
How does #cell size affect #patterning precision in the #embryo?

A novel cell-based simulation framework reveals the impact of cell diameter on #morphogen gradient variability in #tissue #development.

Check out our latest pre-print: https://www.biorxiv.org/content/10.1101/2022.02.02.478800v1

🧵 (1/6)

Hi everyone!

The Vincent lab twitter account completes its migration to Mastodon.
Follow us for cool #DevBio science, mostly working with #Drosophila. We are generally interested in the signalling activities that control patterning, growth and apoptosis in epithelia. Our #morphogen of choice is #Wnt.

Here you may also find the occasional rant from JP once he gets used to the new format. Until then, this account is mostly managed by postdoc Ines.

If you are interested in #cellbiology, #devbio, hedgehog signaling, #cytonemes, #cilia, or #morphogen gradients, check out our open postdoctoral positions at St. Jude Children's Research Hospital! We offer great postdoc salaries (starting at $70K) and benefits, state of the art facilities, and a rich scientific environment.

Boosts appreciated!

https://talent.stjude.org/postdoc/jobs/10281?lang=en-us

RT @DagmarIber
Does self-enhanced #morphogen #degradation improve #patterning #precision in #tissue #development?

Using a cell-based stochastic reaction-diffusion model, we now challenge this long-held view.

Check out our latest pre-print: https://biorxiv.org/cgi/content/short/2022.11.04.514993v1

A short summary:🧵(1/8)