How do morphogen signals instruct stem cells to acquire a specific neuronal identity? A #preprint by Neal Amin, Kevin Kelley and team provides us with a roadmap. 🧫 🛣️ 🧠

Great new #preLight from Monica Tambalo which includes a response from the authors...👀

#preLight 👉 https://prelights.biologists.com/highlights/generating-human-neural-diversity-with-a-multiplexed-morphogen-screen-in-organoids/

#morphogens #organoids #StemCells #neuroscience

"[...] varying the duration of #BMP #signaling leads to either pluripotent, mesodermal, and extraembryonic states, while varying the concentration does not cause efficient mesodermal differentiation at any dose [...] appropriately timed pulse of BMP induces #hPSCs to a mesodermal fate more efficiently that sustained signaling at any concentration. [...] this effect is due to a combinatorial interpretation of the applied BMP signal and induced endogenous #Wnt signaling."
https://www.biorxiv.org/content/10.1101/2022.11.11.516212v1?rss=1
#DevBio #CellFate #GermLayers #morphogens #Differentiation

RT @CUDevBio@twitter.com

New review on ion channels and their contribution to morphogenesis - by our colleagues @BatesLab@twitter.com:
#weCUdevbio #devbio #signaling #morphogens https://twitter.com/BatesLab/status/1493431765079187459

🐦🔗: https://twitter.com/CUDevBio/status/1493432860686299141