Really cool application of Infinity Flow to #MouseModel #Tcells, which allows readout/prediction of >200 surface epitopes on single cells via #FlowCytometry.

https://doi.org/10.1016/j.immuni.2023.06.005

By @maxevrard
#Immunology #TissueImmunity

A novel orthotopic mouse model replicates human lung cancer cachexia. https://doi.org/10.1002/jcsm.13222 #CancerCachexia #LungCancer #MuscleWasting #MouseModel #OrthotopicMouseModel

New results in a mouse model "demonstrate the rapid and potent effects of [artificial light at night] on cerebrovascular networks, highlighting the importance of ALAN mitigation in the context of health and cerebrovascular disease."

https://www.cell.com/iscience/fulltext/S2589-0042(23)01073-8

#Neuroscience #Chronobiology #MouseModel #ModelOrganism #Cerebrovascular #ALAN

#scientists previously believed silent synapses were only present during early development; however, #mousemodel research found that about 30% of all synapses in the cortex are silent.

https://scitechdaily.com/surprising-discovery-mit-neuroscientists-find-that-adult-brain-is-filled-with-millions-of-silent-synapses/

#scientists previously believed silent synapses were only present during early development; however, #mousemodel research found that about 30% of all synapses in the cortex are silent.

https://scitechdaily.com/surprising-discovery-mit-neuroscientists-find-that-adult-brain-is-filled-with-millions-of-silent-synapses/

With new data analysis coming out showing 4 main subtypes of #longcovid, we're always here to help #mousemodel development to address these areas specifically.

https://www.nature.com/articles/s41591-022-02116-3?utm_medium=affiliate&utm_source=commission_junction&utm_campaign=CONR_PF018_ECOM_GL_PHSS_ALWYS_DEEPLINK&utm_content=textlink&utm_term=PID100098473&CJEVENT=ce867ee5968611ed828502d50a1c0e0b

Meet Dr Emily Warren, 1st author of new #OpenAccess paper from Dr Eric Morrow's lab at #BrownUniversity

They developed the 1st lab model of 17q12 deletion syndrome, a copy number variant disorder associated with #neurodevelopmental disorders and #RenalCysts and #diabetes syndrome. The #MouseModel recapitulated many features of the human disorder & will be used to guide #clinical & #mechanistic studies

Interview & research article:
👩🏻‍🔬https://journals.biologists.com/dmm/article/15/12/dmm050017/285934/
📰https://journals.biologists.com/dmm/article/15/12/dmm049752/285935/

#introduction I am Peggy Wei, an #NewPI (3 years old) at #DKFZ . I am also a mother with two children, and a cooking lover. We use #omics and #mousemodel to understand genome integrity and somatic mosaicism in the developing #brain. Other interests include but not limited to #neuropsychiatric disorders , #cancer origin, DNA #replication, #CNV, and #singlemolecule view of DNA damage. I transferred from the other server (@braingenome@scicomm.xyz) because I feel closer to genomics.

#introduction I am Peggy Wei, an #NewPI (3 years old) at #DKFZ . I am also a mother with two children, and a cooking lover. We use #omics and #mousemodel to understand genome integrity and somatic mosaicism in the developing #brain. Other interests include but not limited to #neuropsychiatric disorders , #cancer origin, DNA #replication, #CNV, and #singlemolecule view of DNA damage.

Hi #ScienceMastodon - my lab's most recent findings just hit preprint here: https://www.sciencedirect.com/science/article/pii/S0022202X22018887?via%3Dihub

We discovered a #mousemodel for examining #cSCC where #mice with epidermal deficiency of #KDM6A and #P53 show 100% penetrant, spontaneous cSCC development within a year!

#dermatology and #skincancer have very few models to study cSCC in mice and our lab found one!

#cancer #epigenetics #academicchatter #derm #tumorsuppressors #tumor #scicomm

Referenced link: https://medicalxpress.com/news/2022-06-color-changing-mouse-non-invasively-deep-tissues.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2022-06-color-changing-mouse-non-invasively-deep-tissues.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/medical_xpress/status/1533891815924965381#m

RT by @physorg_com: Color-changing #mousemodel allows researchers to non-invasively study deep tissues @NatureComms https://www.nature.com/articles/s41467-022-30547-6 https://medicalxpress.com/news/2022-06-color-changing-mouse-non-invasively-deep-tissues.html