A preclinical trial in mice demonstrated that an adjuvant in an intranasal vaccine improved mucosal antibody and T cell responses against SARS-CoV-2. The adjuvant both boosted the mucosal immune response and disabled the virus directly. Early days. Remember: mice lie, monkeys exaggerate, and ferrets are not people.

U of M summary / interview
https://www.michiganmedicine.org/health-lab-podcast/there-promise-nasal-covid-vaccine-future

Paper
https://pubmed.ncbi.nlm.nih.gov/37386041/

#Covid #vaccine #nasal #mucosal

Promises and challenges of #mucosal #COVID19 vaccines

"Several mucosal vaccines are currently being developed with the aim of inducing long-lasting protective immune responses at the mucosal sites where #SARSCoV2 infection begins"

https://www.sciencedirect.com/science/article/pii/S0264410X23003961?dgcid=rss_sd_all

#Researchers have developed an #inhalable powder that could protect #lungs and airways from #viral invasion by reinforcing the body’s own #mucosal layer. The powder, called Spherical #Hydrogel Inhalation for Enhanced Lung Defense, or #SHIELD
#FLU #Covid19 #Virology #Biology #Engineering #Medical #sflorg
https://www.sflorg.com/2023/02/vi02092302.html

Supposing I were a #sociopath #psychopath #Pfizer #CEO
In order to max profits I’d want every woman, man & child #addicted to my #products

It probably wouldn’t be in my best interest to develop an ACTUAL #vaccine that created #mucosal immunity b/c that would mean I’d sell less #diabetes #hbp #antiDepressants #pills ☹️
no, no, no;we can’t have that!

Cosmetics is INCREDIBLY jaw-droppingly #lucrative b/c of something called #replenishment
Imagine 300 million people addicted to constant #Rx🤑

🖕🏼that

Good summary of the recent literature on immune #imprinting in #Covid19

Imprinting (a preferential memory response to parts of a pathogen that the immune system has seen before) may limit the effectiveness of variant-adapted booster vaccines.

New approaches including #mucosal vaccines and novel adjuvants are being looked at.

However there is abundant evidence that the current #VaccinesWork to prevent hospitalisation and death.

https://www.nature.com/articles/d41586-023-00086-1

Rethinking #mucosal #vaccines against respiratory #viruses

"Because these viruses generally do not elicit complete and durable protective immunity by themselves, they have not to date been effectively controlled by licensed or experimental vaccines"

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00572-8

@Covidcanada @kudra
🙏🏼🙏🏼🙏🏼🙏🏼🙏🏼
I’m the worst explainer; literally the worst even in regards to my own industry. Your explanation💯

Tend to believe or know things based on personal experience, which is quite unhelpful tbh

Had to “illegally” get #IWantMyNovavax & even convinced my💯ALWAYS-by-the-book-rule&law-abiding SO post my 2 shots,to get #Novavax too

If studies came out proving some
#mucosal protection, I’d believe it as something happens to my nose every time I’m exposed
Annual💉YES!

RT @Parkos_Nusrat@twitter.com

Looking for an enthusiastic #postdocs interested in understanding the #gut #mucosal barrier, #immunology & wound repair.
Meet our lab: http://pathology.med.umich.edu/parkos-nusrat-…
#postdocposition #UniversityofMichigan #postdocjobs

🐦🔗: https://twitter.com/Parkos_Nusrat/status/1602434684373192704

Very nice Clinical Pipeline by @cyrilpedia “#IntranasalVaccines COVID-19 #vaccine fails to induce #mucosal-immunity” at #Nature-Med doi: https://doi.org/10.1038/d41591-022-00106-z

#introduction I am an #immunologist at the #universityoftoronto. I study how our #mucosal immune system can influence our health, especially brain health. I love constructive discussions about science and how to make #academia a better place for everyone. I love #cooking, #gardening, #singing, #canoeing and learning from my 2 sons. Oh and my 3 @Cats too.

#covid
#pandemic

"Our findings indicate that respiratory #mucosal delivery of Ad-vectored multivalent vaccine represents an effective next-generation COVID-19 #vaccine strategy to induce all-around mucosal immunity against current and future VOC."

https://www.cell.com/cell/fulltext/S0092-8674(22)00145-3