*Random* #mutagenesis, i.e. inducing spontaneous genetic #mutations in plants that *may* result in desirable traits, is OK as it has "a long safety record" (since before 2001). But #GMOs (around since 1996) are not, & more precise #geneediting is neither: https://www.euractiv.com/section/agriculture-food/news/eu-court-exempts-gene-modification-technique-from-stricter-rules

@Associazione_Rurale_Italiana

La décision de la CJUE de ne pas faire tomber la mutagénèse in vitro sous la réglementation OGM ouvre un boulevard à un futur dans lequel il serait impossible de savoir si ce qu'on mange et plante est susceptible d'être breveté par les industries OGM.

#GMO #agroecologie #law #mutagenesis #biology #biologie #engineering #eu #justice

RT @EUCourtPress: #ECJ specifies the status of in vitro random #mutagenesis having regard to the #GMO Directive #environment 👉 https://curia.europa.eu/jcms/jcms/Jo2_7052/

🐦🔗: https://n.respublicae.eu/EURLex/status/1622902274040160257

#ECJ specifies the status of in vitro random #mutagenesis having regard to the #GMO Directive #environment 👉 https://curia.europa.eu/jcms/jcms/Jo2_7052/

#SarsCov2 has killed more than 6.8 mn people over past 3 yrs all over the world.
On November, Merck finished trial of #molnupiravir,a 5-days pill treatment for patients at risk of severe #COVID but it was authorized in US and UK in late 2021 coz it lowered chance of hospitalization or death by about 30%
This oral antiviral drug kills #nCov19 virus inducing mutations:
lethal #mutagenesis capability.
Now it's reported that #MerckPill could be giving rise to new mutations of virus in some patients

High-throughput #saturation #mutagenesis generates a high-affinity #antibody against #SARS-CoV-2 #variants using protein surface display assay on a human cell https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011119

Expanded MutaT7 toolkit efficiently and simultaneously accesses all possible transition mutations in bacteria
#mutagenesis

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad003/7009119

@fitterhappierAJ

I remember last year january 22

You #stupid #idiots. You stand in the way of #public #Health You #peabrains do not understand there is no #virtue in #Omicron-based #immunity and #mutagenesis. One #mutation from #Histidine could spell natural #disaster you stupid #frauds. You are #brainless.

@whn

"We set out to systematically investigate global sequencing databases for a signature of #molnupiravir #mutagenesis. We find that a specific class of long phylogenetic branches appear almost exclusively in sequences from 2022, after the introduction of molnupiravir treatment, and in countries and age-groups with widespread usage of the drug."

#Preprint #COVID19 #Covid #Antiviral #SARSCoV2

https://www.medrxiv.org/content/10.1101/2023.01.26.23284998v1

Interesting and important paper solving structures of the RecA filament bound to the various proteins it activates, including LexA.

https://www.pnas.org/doi/10.1073/pnas.2217493120

Loop 2 of RecA intimately associates with bound LexA. Very strongly complementing our findings that phosphorylation of L2 regulates LexA cleavage in the mycobacterial DDR:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389330/

#recA #mutagenesis #dnadamage #genomicintegrity

Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.

#biophysics #IonChannels #physiology #GeneticCodeExpansion

https://www.nature.com/articles/s41467-022-35279-1

😱

Structural insights into p300 regulation and #acetylation-dependent genome organisation
https://www.nature.com/articles/s41467-022-35375-2

- #alphafold model of p300 suggests that the TAZ2 domain is positioned over the p300 HAT active site

- #alphafold model in the presence of NUT AD shows that the TAZ2 domain is displaced from the HAT active site and suggest that the TAZ2 domain auto-inhibits the HAT domain

- domain truncation and #mutagenesis support the #computational #models !

RT @APoetsch@twitter.com

We have several postdoc openings!
https://tu-dresden.de/cmcb/biotec/forschungsgruppen/poetsch/jobs
Our interdisciplinary group works on the #Genomics of #DNAdamage and #Mutagenesis using #ComputationalBiology, #MachineLearning and #AI.
(details in following tweets)

🐦🔗: https://twitter.com/APoetsch/status/1602700790048722946

How could #DNAmethylation contribute to #mutation and #speciation in #whitefish species complexes? We explore this and more in our new #PrePrint!

Considerable #genetic and #epigenetic divergence between benthic-limnetic species

Enrichment of SNPs at CpG sites - methylation-induced #mutagenesis?

Also enriched overlaps between high #FST #SNPs and #DMLs - possible #GeneticAssimilation?

With amazing collaboration from @clairemerot @eric_normandeau and others

Read more: https://www.biorxiv.org/content/10.1101/2022.11.18.517126v1