Molecular #mechanisms of #SARS-CoV-2 #resistance to #nirmatrelvir, Nature: https://www.nature.com/articles/s41586-023-06609-0 #research #antivirals #covid19 #drugs #mutations #mpro #protease

''These viruses are rapidly accruing #mutations, including mutations of #concern, that warrant further examination and highlight an urgent need for active local #surveillance to manage #outbreaks and limit #spillover into other species, including #humans.''

''The potential #impact of the #BA286 #mutations are presently unknown and are currently undergoing careful assessment. WHO continues to call for enhanced surveillance, sequencing, and reporting of SARS-CoV-2 variants as the virus continues to circulate and evolve.''

''The potential #impact of the #BA286 #mutations are presently unknown and are currently undergoing
careful assessment.''

#Scientists call for return of #facemasks as they raise alarm over new #COVID variant #BA6 which has a lot of #mutations

https://newstarget.com/2023-08-18-scientists-raise-alarm-over-new-covid-mutations.html

New #COVID #variant under monitoring carries slew of novel #mutations

https://www.popsci.com/health/pirola-covid-variant-who-cdc/
Nicknamed #Pirola, the BA.2.86 variant has been sequenced in four countries.

@7soulshine7 💯
I lean much more towards thinker vs. feeler, but have had to develop a callousness that makes me …really sad

It’s all grass roots now w/corporate interests as adversaries

People will have questions eventually. Let me clarify, some will & when it happens they will come find us. I got asked about #ba286 just other day & got to give a mini-talk on #mutations #influenza #sarscov2 🌈

It’s kind of like fashion…we’re just #avantgarde in that sense. Where we go fashion follows🖤🖤🖤🖤🖤🖤🖤💗🖤

#Scientists call for return of #facemasks as they raise alarm over new #COVID variant #BA6 which has a lot of #mutations

https://www.naturalnews.com/2023-08-18-scientists-raise-alarm-over-new-covid-mutations.html

''Analysed HPAI #H5N1 virus #genomes from #cats are almost identical..., suggesting a monophyletic origin and a potential common source of infection. They all carry #mutations associated with #mammalian #adaptation in #polymerase gene (both #PB2-E627K and PB2-K526R), allowing for replication at lower temperatures. An assessment of both the HA and NA genes found no other changes of concern in the sequenced viruses.''

Fisk University graduate student Vida Robertson's July highlight features a publication from SBGrid Consortium member Stephen Burley of the RCSB Protein Data Bank, Rutgers University, which appears in JCI Insight and describes the authors crafting of a computational pipeline able to predict how COVID-19 mutations affect the infectivity of variants.
https://www.tumblr.com/sbgridconsortium/724367393390018560/using-the-pdb-to-predict-how-covid-mutations?source=share

<ALT= Receptor binding domain of COVID-19 (blue) binding to ACE2 (green). PDB:7T9L>

#SBGrid #Science #COVID-19 #mutations

Well, I asked #Bard (Google's AI) about whether #mutations could be caused in the #proteins that make up the #capsid of the #virus that is, as #prionism.

The answer was as expected, YES, as this could make the #viruses more #infectious and #lethal.

My #brain is an INEXPLICABLY COOL thing.

#DNA #RNA #Virus #Genome #Mutation #Biophysics #Biology #Molecular #Transcription #Vaccine

https://www.biorxiv.org/content/10.1101/2023.07.18.549478v1
#acceleratedAging #telomere
Oh yay another pre-print on something that was already covered last October🙄

Literally no amount of science will get these people to #wearADamnMask

They don’t give a damn about themselves, so we expect them to care about the rest of society?

Taken me⏱️⏱️to conclude💯 b/c infectious disease isn’t fashion forecasting, but we are in absolute dire demise circumstances w/ free for all #Covid #SARS2 #mutations #Bidenomics

GIVE US UNFETTERED ACCESS TO #novavax now

#COVID19 repeatedly spread between humans and deer, study shows. People spread the #virus to wild white-tailed deer in the United States more than 100 times in late 2021 and early 2022. “If the virus continues to circulate in #deer, as it has in humans, the study suggests that these animals could become a long-term reservoir, allowing the virus to hide out and develop new and potentially more dangerous #mutations.”
https://www.wsiltv.com/news/health/covid-19-repeatedly-spread-between-humans-and-deer-study-shows-raising-concerns-about-animal-reservoirs/article_ea33abee-3573-590d-8e3d-22c636727ecc.html

#Evolution without accidents
https://aeon.co/essays/why-did-darwins-20th-century-followers-get-evolution-so-wrong?utm_source=rss-feed
Despite advances in #molecular #genetics, too many #biologists think that #naturalselection is driven by random #mutations

The combined #effect of #oseltamivir and #favipiravir on #influenza a virus #evolution in patients hospitalized with severe influenza, Antiviral Res.: https://doi.org/10.1016/j.antiviral.2023.105657 #antivirals #mutations #HA #NA #treatment

[Automatic repost https://twitter.com/dystobot/status/1651093800931008513]

RT @systemsBiology1: Novel #mutations in KMT2B offer pathophysiological insights into childhood-onset progressive #dystonia for more https://t.co/YMXnCkymWB

A gifted amateur.

"Ryan Hisner [is] a school science teacher from rural Monroe, Indiana. He has attracted the attention of prominent virologists from all over the world for his uncanny ability to detect unusual mutations to the SARS-CoV-2 genome — mutations that might be a harbinger of the next variant to sweep the world."

https://www.nature.com/articles/d41586-023-01047-4

#CitizenScience #Viruses #Genetics #SARSCoV2 #Mutations #Research

#Viruses can evade #CRISPR/Cas via #mutations that create mismatches between gRNA & viral DNA. @SchellingMAS @GiangNg12638532 @dsashital show that Cas12a can tolerate some mismatches, but they influence outcomes of further viral evolution #PLOSBiology https://plos.io/413LJ8R

#Viruses can evade #CRISPR/Cas via #mutations that create mismatches between gRNA & viral DNA. @SchellingMAS @GiangNg12638532 @dsashital show that Cas12a can tolerate some mismatches, but they influence outcomes of further viral evolution #PLOSBiology https://plos.io/413LJ8R

#Viruses can evade #CRISPR/Cas via #mutations that create mismatches between gRNA & viral DNA. @SchellingMAS @GiangNg12638532 @dsashital show that Cas12a can tolerate some mismatches, but they influence outcomes of further viral evolution #PLOSBiology https://plos.io/413LJ8R