Technican and Lab Manager

Stanford University

@ZucheroLab (http://zucherolab.stanford.edu) is hiring a research technician/lab manager! Come join us @StanfordMed to study #neuroscience and #myelin

See the full job description on jobRxiv: https://jobrxiv.org/job/stanford-university-27778-technican-and-lab-manager/?feed_id=46802

#ScienceJobs #hiring #research
Stanford, CA #UnitedStatesUS #ResearchT...
https://jobrxiv.org/job/stanford-university-27778-technican-and-lab-manager/?feed_id=46802

Technican and Lab Manager @ZucheroLab

@ZucheroLab (http://zucherolab.stanford.edu) is hiring a research technician/lab manager! Come join us @StanfordMed to study #neuroscience and #myelin

https://jobrxiv.org/job/stanford-university-27778-technican-and-lab-manager/?feed_id=44610

#ScienceJobs #job
Stanford, CA #Unite...
https://jobrxiv.org/job/stanford-university-27778-technican-and-lab-manager/?feed_id=44610

Technican and Lab Manager @ZucheroLab

@ZucheroLab (http://zucherolab.stanford.edu) is hiring a research technician/lab manager! Come join us @StanfordMed to study #neuroscience and #myelin

https://jobrxiv.org/job/stanford-university-27778-technican-and-lab-manager/?feed_id=44004

#ScienceJobs #job
Stanford, CA #Unite...
https://jobrxiv.org/job/stanford-university-27778-technican-and-lab-manager/?feed_id=44004

RT @ZucheroLab
What controls the morphology of #myelin sheaths to enable them to fine-tune conduction velocity? TL;DR: Calcium (Ca2+) signaling; a.k.a. nature’s ultimate multitasker! Read our new pre-print to find out more, led by grad student @_manasi_iyer_! 🧵👇(1/n)

Grammy Nominees Are a Brainy Bunch: Music Rewires the Brain

Our brains are hard-wired for the benefits of music. Every time a musician practices, their brains rewire by strengthening synapses, building new neurons, and rebuilding the myelin sheath.

#Neuroscience #Brain #Neuron #Synapse #SynapticPlasticity #Neurogenesis #Myelin #Myelination #Perception #Music

https://neurosciencenews.com/music-rewire-brain-22438/

Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis.
ACS Cent. Sci. 2018, 4, 1, 39–51
https://doi.org/10.1021/acscentsci.7b00367
#ramaneffect #desi
#multiplesclerosis #myelin #lipidomics #openaccess

Really provocative new study on #myelin changes in normal appearing white matter in #multiplesclerosis with increased #microglia activation and perivascular #Tcell accumulation

https://onlinelibrary.wiley.com/doi/10.1002/ana.26585#.Y6yCz_Ef-EM.twitter

Cutting #Brain-gut #Vagus Nerve Lessens Loss of #Myelin in #MS #Mice
Severing the lower part of the vagus nerve that connects the brain and gut led to less myelin loss in a mouse model used to study MS. https://multiplesclerosisnewstoday.com/news-posts/2022/12/22/cutting-brain-gut-vagus-nerve-lessens-myelin-loss-ms-mice/

RT @Pluchinolab@twitter.com

Happening NOW at @CentreMyelin@twitter.com with @TepavcevicVanja@twitter.com from @AchucarroGlia@twitter.com and @MatuteLab@twitter.com speaking of #myelin #ms #progressivems and #cellmetabolism | @CamNeuro@twitter.com @Cambridge_Uni@twitter.com

🐦🔗: https://twitter.com/Pluchinolab/status/1595819127075229696

So time for that #introduction I suppose. I'm a structural biologist mainly working on the #myelin sheath molecules, which include membrane #proteins as well as disordered molecules. We use various tools of #structuralbiology, including #crystallography, #cryoem, and #biophysics. Not sure yet, how much work-related posting will happen here (I feel too old for this platform), but at least you will get to see some #photos of #norway and #dogs.

Did you know that #myelination of neuronal axons by #oligodendrocytes in our #brain is a plastic process in which #myelin structure (white matter) can change in response to neuronal activity?

Here is a very interesting review article by Juliet Knowles and colleagues at Stanford University:

Adaptive and maladaptive myelination in health and disease

#OpenAccess article in Nature Reviews #Neurology: https://www.nature.com/articles/s41582-022-00737-3

#neuroscience #psychiatricdiseases

🧠 Myelin is a fatty wrap that goes around some axons.

🔸 An unmylinated or naked axon can only transfer information at a slow rate. So the rate that it's transfers information is 0.2 to 1 meters per second.

🔸 Now, once we put on #myelin, information transfers much much faster. It can go between 2 and 120 meters per second. If it goes at 120 meters per second, the whole game is over. So very short time, imperceptible to us.

🔸 That information occurs in a 0 or a 1. There's either a point of information or not. **And so it's very much like a computer code**, where what we're seeing is a series of and what's important, the 0s are less important but the temporal pattern of these ones is very important.

🔸 And these 'ones' are actually an action potential, also called a spike. And we talk about firing spikes, neurons fire spikes. So, the timing of these spikes is what carries information.

🔸 The information spikes actually jump. That's what makes it so fast. They don't have to actually be carried through the places; with the #Myelin, they can actually jump.

🔸 And now, if we have a #DemyelinatingDisease, what we're going to end up with is some information that's spread out, because it's slower. And every once in a while, it's going to miss bits.

🔸 The neuron, that we're talking, to is getting a very incoherent message. This is very different from the original message and that is the problem with demyelination. Because axons are demyelinated, the information transfer is very degraded. It's a garbled message and that's a problem.

Image source: Screen-grab from https://www.coursera.org/learn/neurobiology/lecture/B13Z1/myelin.

**Glial Cells**
The human brain contains 86B neurons and 85B Glia.

**Different types of Glia:**

🔸 Astrocytes: Astrocytes are really important type of Glia. They're essentially responsible for keeping the environment clean, they're the sanitation worker of the brain. So they are picking up all the refuse that the neurons have let loose including excess ions, excess #neurotransmitters and their metabolites.

They also are very important during development. They allow neurons to get to where they have to go during development. #Neurons are born in one place and they have to go some place else, and what highway did they take? They hitch on a progenitor cell that is going to become an #Astrocyte.

And, in addition when synapses are formed, the synapses are not maintained without some effort, and part of that is that the synapses are enveloped in the processes of #Astrocytes. So, there's a lot of structural and metabolic support that the Astrocytes are providing for neurons.

🔸 Oligodendrocytes and Schwann Cells: The #oligodendrocytes make myelin in the CNS and the #SchwannCells make it in the Peripheral Nervous System. So all these demyelinating diseases will affect either central myelin or peripheral #myelin. They will not affect both -- central or peripheral.

Because they are made by two different types. The Oligodendrocytes in the central nervous system and a Schwann cells in the peripheral nervous system.

🔸 Microglia: #Microglia are the one exception to the rule that
nervous system, that the cells of the nervous system come from Ectoderm. These are actually essentially immune cells coming from the blood lineage. These are immune cells that have invaded into the central nervous system and their job is to be quiet. And if we're healthy and everything goes well, they are quiet. But when there is a problem these microglia react, they try to rectify things, they try and bring some attention to areas of damage and what is emerging is that sometimes they go overboard and they start to participate in making the problem as well as solving the problem.