#FungiFriday #NatureIsTheOnlyTrueArtist #NatureMicrobiology #naturephotography

We need more #CRISPR Cas systems isolated from bacteria unknown to our immune system. You can look around on this planet, in every single corner. Or you can travel back in time. We chose the second path, and reported the outcome today in #NatureMicrobiology
https://www.nature.com/articles/s41564-022-01265-y

Today we report five ancestral #CRISPR #Cas nucleases generated by maximum likelihood molecular philogeny from bacteria that could have lived 37, 137, 200, 1000 and 2600 Millions years ago and we found that are capable of acting as gene editing tools in human cells. The oldest ancestral Cas are less specific (PAMless) and prefer to cut single strand DNA and RNA. We publish this collaborative study today in #NatureMicrobiology
https://www.nature.com/articles/s41564-022-01265-y