Joanna Masel · @JoannaMasel
1061 followers · 417 posts · Server ecoevo.socialOur preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper
#effectivepopulationsize #aminoAcid #arginine #lysine #valine #isoleucine #thermophile #nearlyneutraltheory #MolecularEvolution #evolgenpaper
Joanna Masel · @JoannaMasel
1030 followers · 340 posts · Server ecoevo.social
Our latest #preprint develops a new metric of #CodonAdaptation (not just #CodonBias) to measure the kind of #EffectivePopulationSize that matters to #NearlyNeutralTheory, and uses it to discover that #NaturalSelection prefers high #IntrinsicStructuralDisorder https://www.biorxiv.org/content/10.1101/2023.03.02.530449v1 1/6
#MolecularEvolution #PopulationGenetics #EvolgenPaper
#preprint #codonadaptation #codonbias #effectivepopulationsize #nearlyneutraltheory #naturalselection #IntrinsicStructuralDisorder #MolecularEvolution #populationgenetics #evolgenpaper