👉 During development, #Netrin1 is released and diffusible in the microenvironment. This study shows that in #cancer, #Netrin1 accumulates in the #ExtracellularMatrix. The authors used this property to follow its in vivo accumulation by radiolabeling and to target netrin-1-expressing tumor cells with #radioimmunotherapy.

By D. Kryza, P. Mehlen, D. Sarrut, B. Gibert & colleagues

Full #openaccess article 🗞️ : https://doi.org/10.15252/emmm.202216732