#Cohesinopathy

BRD4 (acetyl lysine reader)-NIPBL (cohesin loading ) complex is critical to #NeuralCrest differentiation into #SmoothMuscleCell

BRD4 depletion->⏬#GenomeFolding+loop extrusion

BRD4 in #AorticAneurysm?

Dr. Rajan Jain lab Nature Genet 2021
https://www.nature.com/articles/s41588-021-00934-8

Alas, a very windy and wet day in Halifax, Nova Scotia today. Perfect for doing whole mount embryo immunostaining experiments, organoid differentiation assays, and correcting term papers. Also reviewing, meeting guest lecturers, meetings…all the things we do at the university! #neurobiology #developmentalbiology #DevBio #cytoskeleton #neuralcrest

For #MicroscopyMonday a Wnt1cre; tdtomato fetal mouse identifying dorsal root ganglia & craniofacial nerves and cartilages #neuralcrest #DevBio . Taken with a Zeiss Acmxio Zoom stereomicroscope.

New platform, new introduction time!

My name is Mike and I love #cell and #devbio. I'm about to open the Piacentino Lab in the Department of #CellBio at the Johns Hopkins University SOM, and I am excited to study the role of #membrane #lipids in #neuralcrest development! I can't wait to build a welcoming, inclusive, and diverse team of young researchers to help tackle these exciting problems!