Therapeutic Strategies for Spinocerebellar Ataxia Type 1 (SCA1)
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #SpinocerebellarAtaxia #SCA1 #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#Biomedicine #Health
#health #biomedicine #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #SCA1 #SpinocerebellarAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases.
Friedreich’s ataxia represents a test case to validate the potential of therapeutic strategies based on nanoparticles.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#GeneTherapy
#Neuroinflammation
#Mitochondria #MitochondrialDysfunction
#Nanoparticles #Nanomedicine #Nanobiotechnology
#Biomedicine #Health
https://academic.oup.com/brain/article/doi/10.1093/brain/awad014/7024724
#health #biomedicine #Nanobiotechnology #Nanomedicine #nanoparticles #MitochondrialDysfunction #mitochondria #neuroinflammation #genetherapy #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
APOE expression and secretion are modulated by mitochondrial dysfunction
This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.
#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction
#MitochondrialDysfunction #mitochondria #neurogenetics #ApoE #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience #biomedicine
Vatiquinone found to slow Friedreich's Ataxia progression by 75% after 1.5 years
But oral therapy fails to meet primary goal in Phase 2/3 trial
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#Vatiquinone #Neuroinflammation
#Biomedicine #Health
https://friedreichsataxianews.com/news/vatiquinone-slows-fa-progression-after-18-months-trial-data/
#health #biomedicine #neuroinflammation #Vatiquinone #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Short-read genome sequencing test may help diagnose atypical Friedreich's Ataxia
Test advised for patients whose symptoms, family history are not indicative of Friedreich's Ataxia.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
New Friedreich's Ataxia mouse model may aid research, therapy development
Mice house largest reported number of GAA repeats in Frataxin gene
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases #Ataxia #FriedreichAtaxia #Frataxin
https://friedreichsataxianews.com/news/new-fa-mouse-model-may-aid-research-therapy-development/
#Frataxin #FriedreichAtaxia #ataxia #RareDiseases #GeneticDiseases #NeurogeneticDiseases #neurogenetics #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
[Automatic repost https://twitter.com/dystobot/status/1644461326591307789]
RT @GreenJournal: Ashton and colleagues report a novel likely pathogenic variant in the SERAC1 gene associated with early adult-onset parkinsonism and progressive #dystonia. Learn more: https://t.co/ohl4ct2HPJ
#dystonia #neurotwitter #neurogenetics
Intro: I'm a #Biology professor researching the #Neurogenetics of #learning and #memory in #Drosophila. I study how operant or motor memories are formed and how other forms of learning regulate these processes. As spontaneous behavior is required for operant learning, I also study how #spontaneity arises in nervous systems.
Our lab practices #openscience
Disclaimer: Since I got tenure in 2012, my non-tenured co-authors decide where our manuscripts are submitted.
#biology #neurogenetics #learning #memory #drosophila #spontaneity #openscience
Two new posts on preLights today! 👀
The other one has been written by Chee Kiang (Ethan) Ewe - postdoc in the #RechaviLab – who highlights work from the #BuelowLab.
This #preprint shows that the only constant is change – even in “hard-wired” C. elegans. The authors demonstrate the rewiring of an asymmetric neural circuit during associative learning.
#rechavilab #buelowlab #preprint #learning #celegans #insulin #signaling #neurogenetics
Spinal Cord Abnormalities Correlate With Disease Severity in FA
Results show utility of MRI as biomarker in tracking disease progression
Damage to the spinal dorsal column seems developmental whereas damage of the corticospinal tract may be both developmental and degenerative in origin.
#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurodevelopment #NeurodevelopmentalDisorders #Ataxia #FriedreichAtaxia #SpinalCord #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases
#MagneticResonanceImaging #MRI #Biomarker #BrainImaging
https://friedreichsataxianews.com/news/fa-spinal-cord-abnormalities-correlate-with-disease-severity/
#BrainImaging #Biomarker #mri #MagneticResonanceImaging #RareDiseases #GeneticDiseases #NeurogeneticDiseases #neurogenetics #SpinalCord #FriedreichAtaxia #ataxia #neurodevelopmentaldisorders #neurodevelopment #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #neuroscience
Replay targets genetic brain disorders with new gene therapy company, Kaleibe, utilising big DNA HSV technology
#Biomedicine #GeneTherapy #GeneDelivery #MolecularTherapy #ViralVectors #HerpesviralVectors #HSV
#Neurogenetics #Parkinson #FriedreichAtaxia #Ataxia #NeurogeneticDiseases #GeneticDiseases #NeurologicalDiseases #NeurodegenerativeDiseases #BrainDiseases #Neurology #Neuroscience
https://replay.bio/news/replay-targets-genetic-brain-disorders
#neuroscience #neurology #BrainDiseases #NeurodegenerativeDiseases #NeurologicalDiseases #GeneticDiseases #NeurogeneticDiseases #ataxia #FriedreichAtaxia #parkinson #neurogenetics #hsv #HerpesviralVectors #ViralVectors #MolecularTherapy #GeneDelivery #genetherapy #biomedicine
Deep Intronic FGF14 GAA Repeat Expansion identified as the most common cause of Late-Onset Cerebellar Ataxia
#Neuroscience #Neurology #Neurogenetics #NeurologicalDiseases #NeurodegenerativeDiseases #RareDiseases #GeneticDiseases #Genetics #Cerebellum #Ataxia
#ataxia #Cerebellum #genetics #GeneticDiseases #RareDiseases #NeurodegenerativeDiseases #NeurologicalDiseases #neurogenetics #neurology #neuroscience
#introduction time!
Very happy to find some of my Twitter community here.
I'm a researcher at #edinburgh University interested in #neurodevelopment and #neurogenetics
Using #genetics and #statistics to better understand #reading #dyslexia #dyspraxia #language
Big fan of significant #GWAS hits and cute dog posts (probably not in that order). Here's my dog Cara as a puppy for tax.
#GWAS #language #dyspraxia #dyslexia #reading #statistics #genetics #neurogenetics #neurodevelopment #edinburgh #introduction