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This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.

#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction

https://elifesciences.org/articles/85779

#MitochondrialDysfunction #mitochondria #neurogenetics #ApoE #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience #biomedicine

Last updated 1 year ago

Original post

Javier Díaz-Nido · @Javier_DN

169 followers · 342 posts · Server red.niboe.info

Vatiquinone found to slow Friedreich's Ataxia progression by 75% after 1.5 years

But oral therapy fails to meet primary goal in Phase 2/3 trial

#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#Vatiquinone #Neuroinflammation
#Biomedicine #Health

https://friedreichsataxianews.com/news/vatiquinone-slows-fa-progression-after-18-months-trial-data/

#health #biomedicine #neuroinflammation #Vatiquinone #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience

Last updated 1 year ago

Original post

Javier Díaz-Nido · @Javier_DN

169 followers · 330 posts · Server red.niboe.info

Short-read genome sequencing test may help diagnose atypical Friedreich's Ataxia

Test advised for patients whose symptoms, family history are not indicative of Friedreich's Ataxia.

#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics

https://friedreichsataxianews.com/news/short-read-genome-sequencing-may-help-diagnose-atypical-early/

#neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience

Last updated 1 year ago

Original post

Javier Díaz-Nido · @Javier_DN

169 followers · 267 posts · Server red.niboe.info

New Friedreich's Ataxia mouse model may aid research, therapy development

Mice house largest reported number of GAA repeats in Frataxin gene

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases #Ataxia #FriedreichAtaxia #Frataxin

https://friedreichsataxianews.com/news/new-fa-mouse-model-may-aid-research-therapy-development/

#Frataxin #FriedreichAtaxia #ataxia #RareDiseases #GeneticDiseases #NeurogeneticDiseases #neurogenetics #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience

Last updated 2 years ago

Original post

dystobot · @dystobot

5 followers · 4690 posts · Server med-mastodon.com

[Automatic repost https://twitter.com/dystobot/status/1644461326591307789]

RT @GreenJournal: Ashton and colleagues report a novel likely pathogenic variant in the SERAC1 gene associated with early adult-onset parkinsonism and progressive #dystonia. Learn more: https://t.co/ohl4ct2HPJ

#NeuroTwitter #NeuroGenetics https://t.co/XSXufRt5hS

#dystonia #neurotwitter #neurogenetics

Last updated 2 years ago

Original post

Björn Brembs · @brembs

2263 followers · 1122 posts · Server mastodon.social

Intro: I'm a #Biology professor researching the #Neurogenetics of #learning and #memory in #Drosophila. I study how operant or motor memories are formed and how other forms of learning regulate these processes. As spontaneous behavior is required for operant learning, I also study how #spontaneity arises in nervous systems.

Our lab practices #openscience

Disclaimer: Since I got tenure in 2012, my non-tenured co-authors decide where our manuscripts are submitted.

#biology #neurogenetics #learning #memory #drosophila #spontaneity #openscience

Last updated 2 years ago

Original post

preLights · @preLights

516 followers · 92 posts · Server mstdn.science

Open media

Two new posts on preLights today! 👀

The other one has been written by Chee Kiang (Ethan) Ewe - postdoc in the #RechaviLab – who highlights work from the #BuelowLab.

This #preprint shows that the only constant is change – even in “hard-wired” C. elegans. The authors demonstrate the rewiring of an asymmetric neural circuit during associative learning.

📜 https://prelights.biologists.com/highlights/restructuring-of-an-asymmetric-neural-circuit-during-associative-learning/

#learning, #Celegans #insulin #signaling #neurogenetics

#rechavilab #buelowlab #preprint #learning #celegans #insulin #signaling #neurogenetics

Last updated 2 years ago

Original post

Javier Díaz-Nido · @Javier_DN

131 followers · 137 posts · Server red.niboe.info

Open media

Spinal Cord Abnormalities Correlate With Disease Severity in FA

Results show utility of MRI as biomarker in tracking disease progression

Damage to the spinal dorsal column seems developmental whereas damage of the corticospinal tract may be both developmental and degenerative in origin.

#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurodevelopment #NeurodevelopmentalDisorders #Ataxia #FriedreichAtaxia #SpinalCord #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases
#MagneticResonanceImaging #MRI #Biomarker #BrainImaging