Postdoctoral Fellow on Neuroimmunology

UAB School of Medicine

Research on #BloodBrainCommunications, #Glia, #BrainDevelopment, #ExtracellularVesicles, #ExtracellularParticles in #Neuroimmunology lab.

See the full job description on jobRxiv: https://jobrxiv.org/job/uab-school-of-medicine-27778-postdoctoral-fellow-on-blood-brain-communication/?feed_id=58280

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"Most recent studies support the hypothesis that T cells worsen disease, but new research from Su et al.4 reported in this issue of Nature Immunology instead describes brain-infiltrating CD8+ T cells as protectors, not perpetrators, of #Alzheimer’s disease pathology."
#Immunology #Neuroimmunology

https://www.nature.com/articles/s41590-023-01622-x

#IDMastodon #microbiology #BraingutAxis #Neuroimmunology lactate-induced HIF1α activation in the context of CNS #autoimmunity initiates a regulatory loop in DCs that limits #immunopathology.

#IDMastodon #BraingutAxis #Neuroimmunology @naturemedicine
lactate-induced HIF1α activation in the context of CNS #autoimmunity initiates a regulatory loop in DCs that limits #immunopathology.

Postdoctoral Fellow on Blood-Brain Communication

UAB School of Medicine

Research opportunities on #Blood-Brain-Communication via #ExtracellularVesicles, and #ExtracellularParticles in #Neuroimmunology Lab.

See the full job description on jobRxiv: https://jobrxiv.org/job/uab-school-of-medicine-27778-postdoctoral-fellow-on-blood-brain-communication/?feed_id=56672

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https://jobrxiv.org/job/uab-school-of-medicine-27778-postdoctoral-fellow-on-blood-brain-communication/?feed_id=56672

'One may even speculate that there might be individual microglial populations that are specialized to deal with the different pathological challenges of AD. Thus, microglial activation is an integral component of the amyloid cascade and not just an alternate disease-causing pathway unrelated to amyloid-driven events.'
#immunology #Neuroimmunology #alzheimers #Microglia

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001694

"They have investigated the brains of ageing mice, elucidating the source of the cGAS–STING trigger and the particular cells in which this pathway is activated (Fig. 1). Specifically, the authors find that cytosolic DNA derived from perturbed mitochondria activates the pathway in ageing microglia, the main immune cells in the brain — an observation that agrees with earlier findings that cGAS–STING is involved in activating microglia and in neuroinflammation"
#Immunology #Neuroimmunology #NeurodegenerativeDisease #InnateImmunity

https://www.nature.com/articles/d41586-023-02240-1

'For example, loss of function of the microglial gene Trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and Trem2 variants are among the strongest genetic risk factors for AD. Thus, restoring microglial function represents a rational therapeutic approach. Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a Trem2 mutant mouse model of AD.'

#Alzheimer #NeurodegenerativeDisease #Microglia #Neuroimmunology

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00251-5#%20

#IDMastodon #Neurocovid #Neurobiology #viralimmunology #Neuroimmunology @cellpress #SARSCoV2 is associated with broad tissue tropism, a characteristic often determined by the availability of entry receptors on host cells. TMEM106B, a lysosomal transmembrane protein, can serve as an alternative receptor for 🦠 entry into ACE2-negative cells .

#IDMastodon #Neuroimmunology #Neurocovid @frontimmunol
Compelling evidence for a causal effect of #COVID19 phenotype on AQP4+ NMOSD, shedding new light on the understanding of the comorbidity between #COVID19 & #neuromyelitisopticaspectrumdisorder . The underlying pathogenesis is that #SARSCoV2 infection of multiple cells, macrophages, neutrophils & dendritic cells, induces an #immuneresponse in #Tcells & #Bcells

'Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland–innervating neurons.'

#immunology #Macrophage #Neuroimmunology

https://www.science.org/doi/10.1126/science.abn6366

Discovering the hidden connections between neurons and immune cells in pain perception.

First preLight post from Patrick Penndorf #mpi_ie #FEBSnet covering a #preprint from Aakanksha Jain and team. Includes a response from the authors...👀

#preLight 👉 https://prelights.biologists.com/highlights/nociceptor-neuroimmune-interactomes-reveal-cell-type-and-injury-specific-inflammatory-pain-pathways/

#Neuroimmunology

'We show here that lipid-mediated engagement of invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epithelial cells, promoted peripheral serotonin (5-HT) release via a CD1d-dependent manner, regulating gut motility and hemostasis.'

#Immunology #MucosalImmunology #Neuroimmunology

https://www.cell.com/immunity/fulltext/S1074-7613(23)00236-4

#IDMastodon #Neuroimmunology #Neurocovid @BrainBehavImm Recent evidence from viral RNA detection in umbilical cord blood & amniotic fluid, as well as the discovery of additional entry receptors in fetal tissues suggests a potential for viral transmission to & infection of the fetus and the potential for consequential neurological infection or inflammation in utero.. #neonates exposed to maternal #COVID19 during later development have displayed neurodevelopmental & motor skill deficiencies

Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Neuroimmunology #Neuroimmune #ReactiveAstrocytes #Astrocytes #Glia #Alzheimer #Parkinson #Biomedicine #Health

https://www.nature.com/articles/s41582-023-00822-1

IL6 is not always the bad guy.

"In the penumbrae of human stroke brain lesions, we identified a subpopulation of microglia that express vascular endothelial growth factor A. These cells, termed ‘repair-associated microglia’ (RAMs), were also observed in a rodent model of CVI and coexpressed interleukin (IL)-6Ra. Cerebrovascular repair did not occur in IL-6 knockouts or in mice lacking microglial IL-6Ra expression"
#Immunology #Inflammation #Microglia #Neuroimmunology

https://www.nature.com/articles/s41590-023-01521-1

'Initially, the researchers considered the idea that glucocorticoids act directly on immune cells, which respond by releasing molecules that cause inflammation. “But it turns out that there is a sort of layer in between,” Thaiss says. Working in mice, they found that glucocorticoids act instead on neurons in the gut and on cells called glia that connect gut neurons to one another.'
#Immunology #Neuroimmunology

https://www.nature.com/articles/d41586-023-01700-y

Postdoctoral researcher

Human Technopole

Position for a fully-funded postdoctoral researcher in the @Harschnitz group @HumanTechnopole in Milan. #stemcells #neuroimmunology #virology

See the full job description on jobRxiv: https://jobrxiv.org/job/human-technopole-27778-postdoctoral-researcher/?feed_id=46256

#ScienceJobs #hiring #research
Milan #Italy #PostdoctoralFellow
https://jobrxiv.org/job/human-technopole-27778-postdoctoral-researcher/?feed_id=46256

#IDMastodon #viralimmunology #Neuroimmunology #Neurocovid The end game .Neurological manifestations of #longCOVID exist as a major complication of #COVID19 post-infection, affecting up to one third of patients with #COVID symptoms lasting longer than 4 weeks. Although #SARSCoV2 neurotropism, viral-induced coagulopathy, endothelial disruption, systemic inflammation, cytokine overactivation and neuroglial dysfunction have been hypothesized

RT @jobRxiv
Postdoctoral researcher @humantechnopole

Position for a fully-funded postdoctoral researcher in the @harschnitz group @humantechnopole in Milan. #stemcells #neuroimmunology #virology

https://jobrxiv.org/job/human-technopole-27778-postdoctoral-researcher/?feed_id=44136

#ScienceJobs #job
Milan #Italy #Postdo...
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