Tom Kindlon · @tomkindlon
777 followers · 2079 posts · Server disabled.social#COVID19 Induces #Neuroinflammation & Suppresses Peroxisomes in the Brain
“The present studies point to a role of persistent neuroinflammation, especially inflammasome activation, and peroxisome biogenesis factor suppression as contributing determinants of the neurological sequelae of #COVID-19”
@longcovid #LongCovid #PwLC #PostCovidSyndrome #LC #postcovid @covid @covid19 #COVID #COVID_19 #SARSCoV2 @novid #novid #CovidIsNotOver
#COVID19 #neuroinflammation #covid #LongCovid #pwlc #postcovidsyndrome #lc #PostCovid #COVID_19 #sarscov2 #novid #CovidIsNotOver
Mr.Trunk · @mrtrunk
12 followers · 19320 posts · Server dromedary.seedoubleyou.meGizmodo: An Existing Drug for Multiple Sclerosis Might Be Useful for Alzheimer's Too, Study Finds https://gizmodo.com/ms-ponesimod-might-be-useful-alzheimers-therapy-study-1850803952?utm_source=regular #insulindegradingenzyme #healthmedicalpharma #neuroinflammation #alzheimersdisease #amyloidplaques #amyloidosis #amyloidbeta #macrophages #glialcells #microglia #zhihuizhu #trem2
#insulindegradingenzyme #healthmedicalpharma #neuroinflammation #alzheimersdisease #amyloidplaques #amyloidosis #amyloidbeta #macrophages #glialcells #microglia #zhihuizhu #trem2
Empiricism · @empiricism
431 followers · 2299 posts · Server sustainability.masto.host
Recent extensive evidence indicates that air pollution, in addition to causing respiratory and cardiovascular diseases, may also negatively affect the brain and contribute to central nervous system diseases. https://doi.org/10.1016/j.pharmthera.2020.107523
#AirPollution #disease #Alzheimers #Autism #NeuroInflammation #NeurodegenerativeDiseases #NeurodevelopmentalDisorders #Neurotoxicity #OxidativeStress
#BrainDamage #disease #mortality #death
#airpollution #disease #alzheimers #autism #neuroinflammation #neurodegenerativediseases #neurodevelopmentaldisorders #neurotoxicity #oxidativestress #braindamage #mortality #death #climatechange
Empiricism · @empiricism
431 followers · 2299 posts · Server sustainability.masto.hostEffects of air pollution on the nervous system.
Recent extensive evidence indicates that air pollution, in addition to causing respiratory and cardiovascular diseases, may also negatively affect the brain and contribute to central nervous system diseases. https://doi.org/10.1016/j.pharmthera.2020.107523
#AirPollution #disease #Alzheimers #Autism #NeuroInflammation #NeurodegenerativeDiseases #NeurodevelopmentalDisorders #Neurotoxicity #OxidativeStress
#BrainDamage #disease #mortality #death
#airpollution #disease #alzheimers #autism #neuroinflammation #neurodegenerativediseases #neurodevelopmentaldisorders #neurotoxicity #oxidativestress #braindamage #mortality #death #climatechange
Hari Tulsidas :verified: · @haritulsidas
319 followers · 1589 posts · Server masto.ai
The skull is not just a passive protector of the brain, but an active participant in brain health. A new study found that bone marrow cells in the skull have a unique response to inflammation in the brain and can communicate with the brain through special connections. This discovery could lead to new ways of diagnosing and treating brain diseases, such as Alzheimer's and stroke, by using the skull as a window to the brain.
#skull #brainhealth #neuroinflammation
TrangAston :verified: · @CastlTrAstonDrs
1351 followers · 2780 posts · Server med-mastodon.com
@frontimmunol by producing interferon & drives the accumulation of pro-inflammatory chemokines and cytokines. creating a “#cytokinestorm” that invades and damages the central and peripheral nervous system, leading to #neuroinflammation & #demyelination .
#COVID19 and the risk of NMOSD : a Mendelian randomization study
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1207514/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit
#cytokinestorm #neuroinflammation #demyelination #COVID19
Javier Díaz-Nido · @Javier_DN
171 followers · 359 posts · Server red.niboe.infoAstrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
Aβ was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast+).
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #BetaAmyloid #AmyloidPlaques #Tau #NeurofibrillaryTangles #ReactiveAstrocytes #Astrocytes #Glia #GFAP #Biomarker #Alzheimer #Biomedicine #Health
#health #biomedicine #Alzheimer #Biomarker #GFAP #Glia #astrocytes #ReactiveAstrocytes #NeurofibrillaryTangles #Tau #AmyloidPlaques #BetaAmyloid #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
171 followers · 356 posts · Server red.niboe.infoFunctional roles of reactive astrocytes in neuroinflammation and neurodegeneration
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Neuroimmunology #Neuroimmune #ReactiveAstrocytes #Astrocytes #Glia #Alzheimer #Parkinson #Biomedicine #Health
#health #biomedicine #parkinson #Alzheimer #Glia #astrocytes #ReactiveAstrocytes #Neuroimmune #neuroimmunology #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
170 followers · 351 posts · Server red.niboe.infoMultifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases.
Friedreich’s ataxia represents a test case to validate the potential of therapeutic strategies based on nanoparticles.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#GeneTherapy
#Neuroinflammation
#Mitochondria #MitochondrialDysfunction
#Nanoparticles #Nanomedicine #Nanobiotechnology
#Biomedicine #Health
https://academic.oup.com/brain/article/doi/10.1093/brain/awad014/7024724
#health #biomedicine #Nanobiotechnology #Nanomedicine #nanoparticles #MitochondrialDysfunction #mitochondria #neuroinflammation #genetherapy #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Eric's Risk Assessment · @EricCarroll
2225 followers · 3743 posts · Server zeroes.ca
Paper looks at a biomarker for brain inflammation in patients with #LongCovid depressive & cognitive symptoms.
#Neuroinflammation After #COVID19 With Persistent Depressive and Cognitive Symptoms
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2805366
Popular press coverage: https://globalnews.ca/news/9738168/long-covid-brain-inflammation-study/
#LongCOVID #neuroinflammation #covid19
TrangAston :verified: · @CastlTrAstonDrs
1278 followers · 2494 posts · Server med-mastodon.com
Persistent #neuroinflammation in LC
📌 https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2805366?guestAccessKey=17ff761d-a468-4da1-99bf-674ab965aa99&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=053123
📌 https://www.camh.ca/en/camh-news-and-stories/camh-study-confirms-ongoing-brain-inflammation-associated-with-long-covid https://www.camh.ca/en/camh-news-and-stories/camh-study-confirms-ongoing-brain-inflammation-associated-with-long-covid
Javier Díaz-Nido · @Javier_DN
169 followers · 342 posts · Server red.niboe.infoVatiquinone found to slow Friedreich's Ataxia progression by 75% after 1.5 years
But oral therapy fails to meet primary goal in Phase 2/3 trial
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#Vatiquinone #Neuroinflammation
#Biomedicine #Health
https://friedreichsataxianews.com/news/vatiquinone-slows-fa-progression-after-18-months-trial-data/
#health #biomedicine #neuroinflammation #Vatiquinone #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Joe Sabatino · @jsabatino37
96 followers · 198 posts · Server fediscience.orgRT @GrohJanos
Happy to share the final version of our article on mutant myelinating #glia, #neuroinflammation, #axon degeneration, and CD8+ CNS-associated #Tcells in @iScience_CP: https://doi.org/10.1016/j.isci.2023.106698
Many thanks to everyone involved! https://twitter.com/GrohJanos/status/1613097076153262082
#tcells #axon #neuroinflammation #glia
Javier Díaz-Nido · @Javier_DN
167 followers · 259 posts · Server red.niboe.infoPeripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Inflammation #ImmuneResponse #Parkinson
#parkinson #ImmuneResponse #inflammation #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
166 followers · 251 posts · Server red.niboe.infoImaging Study Implicates Reactive Astrocyte-Neuron Interaction in Alzheimer’s Cognitive Decline
PET imaging with 11C-acetate and 18F-FDG was used to visualize the reactive astrocyte-induced acetate hypermetabolism and associated neuronal glucose hypometabolism in brains with neuroinflammation and Alzheimer’s Disease.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #BrainImaging #Neuroimaging #NeuroMetabolism #AcetateHypermetabolism #GlucoseHypometabolism #NeuroInflammation #CognitiveDecline #CognitiveDysfunction
#CognitiveDysfunction #CognitiveDecline #neuroinflammation #GlucoseHypometabolism #AcetateHypermetabolism #NeuroMetabolism #neuroimaging #BrainImaging #Alzheimer #neuron #astrocyte #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
161 followers · 215 posts · Server red.niboe.infoFresh Understanding of Aging in the Brain Offers Hope for Treating Neurological Diseases
As the brain ages, microglia adopt dysfunctional states that increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Alzheimer #Neurodegeneration #Neuroinflammation #Microglia #BrainAging #Aging
#aging #BrainAging #microglia #neuroinflammation #Neurodegeneration #Alzheimer #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
TrangAston :verified: · @CastlTrAstonDrs
1146 followers · 1783 posts · Server med-mastodon.com
#IDMastodon #IDtwitter #Immunology Potential molecular mechanisms of #chronicfatigue & #Neuroinflammation in ME/CFS ,#LongCovid &other viral diseases @BioMedCentral
📌 https://infectagentscancer.biomedcentral.com/articles/10.1186/s13027-023-00485-z?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_BMC
📌 https://www.biomedcentral.com/collections/COVID19Cancer
#IDMastodon #IDtwitter #immunology #chronicfatigue #neuroinflammation #LongCovid
Rhyothemis · @Rhyothemis
168 followers · 854 posts · Server zeroes.ca
CCL11 (aka eotaxin-1) has been found to be elevated in ppl w/ Long Covid cognitive symptoms [1] & this could contribute to neuroinflammation.
Montelukast lowers CCL11 & research on repurposing for Alzheimer's is underway [2]. However, montelukast use has been linked to increased suicidal ideation.
Does anyone know why it would increase suicidal ideation?
1 - https://doi.org/10.1101/2022.01.07.475453
2 - https://clinicaltrials.gov/ct2/show/NCT03991988
#montelukast #neuroinflammation #ccl11
Perceptions Today · @PerceptionsToday
53 followers · 188 posts · Server mastodonapp.uk
#Calcium Channels Regulate #Neuroinflammation and #Neuropathic #Pain
https://neurosciencenews.com/neuroinflammation-neuropathy-orai1-22401 #biology #neuroscience #brain
#calcium #neuroinflammation #neuropathic #pain #biology #neuroscience #brain
Aging Highlights · @senescence
233 followers · 133 posts · Server mas.toAgeing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination
#aging #preprint #biorxiv #neuroscience #neuroinflammation #immunology
#immunology #neuroinflammation #neuroscience #biorxiv #preprint #aging