PLOS Biology · @PLOSBiology
5109 followers · 1634 posts · Server fediscience.org
Screen in #Celegans yields potential targets to delay motor #aging, including the PI3K VPS-34. VPS-34 inhibition improves #neurotransmission & muscle integrity via increased PI(3)P-PI-PI(4)P conversion, improving #MotorAging in worms & mice #PLOSBiology https://plos.io/3XNjhHn
#plosbiology #motoraging #neurotransmission #aging #Celegans
The vOICe vision · @seeingwithsound
351 followers · 904 posts · Server mas.toBeen wondering for many years: there must be undiscovered receptors in the brain? For me, #fresh #orange #juice consistently clears #brain #fog in seconds, and more strongly so than #coffee; no such effect after fermentation; #neuroscience #neurotransmission #neurotransmitter
#neurotransmitter #neurotransmission #neuroscience #coffee #fog #brain #juice #orange #fresh
Andrew Plested · @andrewplested
231 followers · 632 posts · Server mstdn.scienceStructures of my old friend kainate receptor GluK2 with the no-longer AMPA-receptor specific anti-epileptic drug Perampanel bound, and a blocker of desensitisation. Sobolevsky lab.
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00135-3
#IonChannels #neurotransmission #epilepsy
PLOS Biology · @PLOSBiology
4642 followers · 716 posts · Server fediscience.org
The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0
#plosbiology #fragilex #noonansyndrome #neurotransmission #FMRP
PLOS Biology · @PLOSBiology
4626 followers · 698 posts · Server fediscience.org
The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0
#plosbiology #fragilex #noonansyndrome #neurotransmission #FMRP
PLOS Biology · @PLOSBiology
4625 followers · 694 posts · Server fediscience.org
The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0
#plosbiology #fragilex #noonansyndrome #neurotransmission #FMRP