#IDMastodon #virology These observations suggest that BA.2.86 is more closely related to sequences from Southern Africa than other regions & so may have evolved there, and that evolution led to escape from #neutralizingantibodies similar in scale to recently circulating strains of #SARSCoV2.
https://www.medrxiv.org/content/10.1101/2023.09.08.23295250v1.full.pdf

https://www.biorxiv.org/content/10.1101/2023.04.08.536123v1 “#SARSCoV2 continues to evolve and #evade most existing #NeutralizingAntibodies, including all clinically authorized antibodies. We have isolated and characterized two human #MonoclonalAntibodies, 12-16 and 12-19, which exhibited neutralizing activities against all SARS-CoV-2 #variants tested, including BQ.1.1 and XBB.1.5. They also blocked infection in hamsters challenged with Omicron BA.1 intranasally”

@cellpress Pan-betacoronavirus #NeutralizingAntibodies may hold the key to developing broadly
protective vaccines against novel pandemic coronaviruses and to more effectively
respond to #SarsCoV2 variants.
📌 https://www.cell.com/action/showPdf?pii=S1074-7613%2823%2900079-1

“results of these studies vary in terms of estimates of the level of #NeutralizingAntibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from #COVID19. This finding can be useful for planning future #vaccine use,” #correlates

https://wwwnc.cdc.gov/eid/article/29/2/22-1422_article