Why do some #asthma patients have a poor response to inhaled #corticosteroids?

A new @ScienceTM study in mice and humans now connects #neutrophil activity with corticosteroid resistance. https://scim.ag/35x #press

Why do some #asthma patients have a poor response to inhaled #corticosteroids?

A new @ScienceTM study in mice and humans now connects #neutrophil activity with corticosteroid resistance. https://scim.ag/33p #press

@gpollara It also raises the question, whether phagocytosing capabilities and surface markers are really correctly attributed already...and if we might need an update of our classification system for inflammatory states also... #macrophage #neutrophil

Fantastic #neutrophil lab trip to #budapest last week for the European Phagocyte workshop, excellent scientific discussions and fab location

Fantastic #neutrophil lab trip to #budapest last week for the European Phagocyte workshop, excellent scientific discussions and fab location

"As expected, early on-target recognition of melanoma antigens by tumor-specific CD4+ T cells was required. Surprisingly, complete tumor eradication was dependent on neutrophils and partly dependent on inducible nitric oxide synthase."

#Immunology #Immunotherapy #checkpointinhibitors #Neutrophil

https://www.cell.com/cell/pdf/S0092-8674(23)00225-8.pdf

Nice little study this, using SNPs in CCL19 & CCL21 linked with higher levels of these chemokines associated with greater #COVID19 infection and mortality.

Wonder if there's a mechanism. Greater #Neutrophil chemotaxis 👉 tissue pathology?

#IDMastodon #MedMastodon #immunopathology #immunology

CCL19 (rs3136658) and CCL21 (rs2812377) variants are associated with susceptibility and related mortality of SARS-CoV-2 infection: a population-based correlation analysis

https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad032/7022103

#Neutrophil homing to the liver constitutes a major pathophysiological process in alcoholic #LiverDisease (ALD) by promoting #inflammation, producing ROS, and altering metabolism. The chromatin remodeling protein Brg1 activates transcription of CXCL14 in hepatocytes to drive neutrophil trafficking.

By Z. Li, Z. Fan, Y. Xu & colleagues at Nanjing University

🗞️ https://doi.org/10.15252/emmm.202216592

The collection of immune cell proteomes is really growing at http://ImmPRes.co.uk. Simply fantastic resource.
#Tcells (of many types)
#NKcells
#Neutrophils
#Macrophage
#Bcells
#Basophils
#TheListGoesOn

I know for a fact there’s lots of new datasets on the way too 😁
---
RT @ImmPRes_
we have now added our first #neutrophil dataset to ImmPRes. What effect does hypoxia have on neutrophils when they're activated with LPS? and what happens …
https://twitter.com/ImmPRes_/status/1610671220810203137

"Conditional absence of C3aR1/C5aR1 on neutrophils lowered serum BAFF levels, led to fewer Peyer’s patch germinal center B cells, reduced germinal center B cells IgA class-switching, and lowered fecal IgA levels. Together, the results indicate that sequential activation of complement on neutrophils crucially supports humoral TI and mucosal IgA responses through upregulating neutrophil production of BAFF."

#Immunology #TIndependentResponse #Neutrophil #BAFF

Hackaday Links: December 18, 2022 https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/ #structuralcollapse #electronicscourse #HackadayColumns #ManhattanStyle #Hackadaylinks #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #Slider #berlin #USNavy #neets #ugly #drm

Hackaday Links: December 18, 2022 - By now everyone has probably seen the devastation wrought by the structural failur... - https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/ #structuralcollapse #electronicscourse #hackadaycolumns #manhattanstyle #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #slider #berlin #usnavy #neets #ugly #drm

Cardelli, M., Pierpaoli, E., Marchegiani, F. et al. #Biomarkers of cell damage, #neutrophil and #macrophage activation associated with in-hospital #mortality in #geriatric #COVID19 patients. Immun Ageing 19, 65 (2022). https://doi.org/10.1186/s12979-022-00315-7

Another potential new role for eosinophils.

Antibacterial activity and associated with colitis.

They're increasingly taking on the role of simply a neutrophil subset!
#immunology #ScienceMastodon #neutrophil #eosinophil

https://www.nature.com/articles/s41586-022-05628-7?error=cookies_not_supported&code=272b7fea-57d3-447e-bb33-776166afd884&utm_medium=Social&utm_campaign=nature&utm_source=Twitt

ICAM1-hi #EndothelialCell form Hotspots for #Neutrophil #TransEndothelialMigration (Paracellular)

Blunting ICAM1 heterogeneity
⏬TEM hotspots
⏫TEM-associated endothelial Permeability

Dr. Jaap van Buul lab @emboreports 2022 @joachimgoedhart @VanBuul_lab
https://www.embopress.org/doi/full/10.15252/embr.202255483

Impossible to make a better presentation on this great paper than first-author Max Grönloh @GronlohMax 👇

Also don't miss the informative Discussion session synthesizing the signaling networks of leukocyte TEM

Congratulations!👏👏👏

https://twitter.com/GronlohMax/status/1593299324192047110

Look at this gorgeous movie on Neutrophil (Green) talking with #EndothelialCell (Blue), #Pericyte (Magenta) & #MastCell (Cyan) in Venule during #Diapedesis 2 h post-TNFα challenge 🤩

Perivascular #MastCell IL-17A->
⏫MC-proximal venular #Pericyte/Mural cell (not #EndothelialCell) Surface presentation of ICAM1 & CXCL1->
⏫#Neutrophil #Diapedesis in subendothelial space

Dr. Mathieu-Benoit Voisin lab @NatureComms 2022 @RegisJoulia
https://www.nature.com/articles/s41467-022-34695-7

Tomorrow young MSc students will watch this iconic movie of a #Leukocyte (#neutrophil) chasing a #Bacteria

This version is taken from 16 mm video made by David Elliot Rogers @VanderbiltU in the 1950s!

(as @Mag2Art says "the Citizen Kane of #Microscopy)

#CellMigration #SciComm

Tomorrow young MSc students will watch this iconic movie of a #Leukocyte (#neutrophil) chasing a #Bacteria.

This version is taken from 16 mm video made by David Elliot Rogers @VanderbiltU in the 1950s.

(as @Mag2Art says "the Citizen Kane of #Microscopy)

#CellMigration #SciComm

"Activity tracing by plasma proteomic profiling uncovered an association between low NET clearance and increased COVID-19 pathology and mortality. Low NET clearance activity with comparable proteome associations was prevalent in healthy donors with low-grade inflammation, implicating defective chromatin clearance in the development of cardiovascular disease and linking COVID-19 susceptibility to pre-existing conditions"

#Immunity #Immunology
#Neutrophil #COVID19 #Pathology

https://www.cell.com/immunity/fulltext/S1074-7613(22)00597-0

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00412-8 ⚡️Fantastic work Lael Yonker lab @LaelYonker

#MISC could be mechanistically linked to persistent #covid19 antigenemia, driven by uncontrolled neutrophil activation and NETosis
⚡️Spike immune complexes trigger NETs

#PedsICU #LongCovid @ChrisCarrollMD @LaelYonker #longcovidkids #Neutrophil #immunology