Giuseppe Michieli · @GMIK69
105 followers · 2158 posts · Server mstdn.scienceMolecular #mechanisms of #SARS-CoV-2 #resistance to #nirmatrelvir, Nature: https://www.nature.com/articles/s41586-023-06609-0 #research #antivirals #covid19 #drugs #mutations #mpro #protease
#mechanisms #sars #resistance #nirmatrelvir #research #antivirals #COVID19 #drugs #mutations #mpro #protease
Giuseppe Michieli · @GMIK69
93 followers · 1826 posts · Server mstdn.scienceCox, R.M., Lieber, C.M., Wolf, J.D. et al. Comparing #molnupiravir and #nirmatrelvir/ritonavir #efficacy and the effects on #SARS-CoV-2 #transmission in animal #models. Nat Commun 14, 4731 (2023). https://doi.org/10.1038/s41467-023-40556-8 #research #science #antivirals #prophylaxis
#molnupiravir #nirmatrelvir #efficacy #sars #transmission #models #research #Science #antivirals #prophylaxis
TrangAston :verified: · @CastlTrAstonDrs
1336 followers · 2719 posts · Server med-mastodon.com
@Nature Ensitrelvir treatment of hamsters infected with the virus possessing Nsp5-M49L/E166A was ineffective; however, #nirmatrelvir or #molnupiravir treatment was effective. Therefore, it is important to closely monitor the emergence of #ensitrelvir-resistant #SarsCoV2 variants to guide antiviral treatment selection.
In vitro and in vivo characterization of #SarsCoV2 resistance to #ensitrelvir
https://www.nature.com/articles/s41467-023-40018-1
#nirmatrelvir #molnupiravir #ensitrelvir #SarsCoV2
Giuseppe Michieli · @GMIK69
82 followers · 1660 posts · Server mstdn.science''#Ensitrelvir #treatment of hamsters infected with the virus possessing Nsp5-M49L/E166A was ineffective; however, #nirmatrelvir or #molnupiravir treatment was effective. Therefore, it is important to closely monitor the emergence of ensitrelvir-resistant SARS-CoV-2 variants to guide antiviral treatment selection.''
#ensitrelvir #Treatment #nirmatrelvir #molnupiravir
Giuseppe Michieli · @GMIK69
69 followers · 1434 posts · Server mstdn.science''Conclusion: #Nirmatrelvir–ritonavir was effective in reducing 30-day #hospitalization and #death. #Molnupiravir was associated with a benefit for 30-day mortality but not hospitalization. Further reductions in mortality from 31 to 180 days were observed with both antivirals.''
#nirmatrelvir #Hospitalization #death #molnupiravir
Giuseppe Michieli · @GMIK69
69 followers · 1433 posts · Server mstdn.scienceEffectiveness of #COVID-19 #Treatment With #Nirmatrelvir–Ritonavir or #Molnupiravir Among #US #Veterans: Target #Trial #Emulation Studies With One-Month and Six-Month Outcomes, Ann Intern Med., https://doi.org/10.7326/M22-3565
#covid #Treatment #nirmatrelvir #molnupiravir #us #veterans #Trial #emulation
Giuseppe Michieli · @GMIK69
69 followers · 1382 posts · Server mstdn.scienceHigh-titer #convalescent #plasma plus #nirmatrelvir/ritonavir #treatment for non-resolving #COVID-19 in six immunocompromised patients https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad144/7185842?rss=1
#convalescent #plasma #nirmatrelvir #Treatment #covid
TrangAston :verified: · @CastlTrAstonDrs
1271 followers · 2463 posts · Server med-mastodon.com
#publichealth #DrugDevelopment @fda_drug_info Approves First Oral #Antiviral (#Paxlovid / #nirmatrelvir tablets, co-packaged for oral use) for the treatment of mild-to-moderate #COVID19 in adults who are at high risk for progression to severe #COVID19, including hospitalization or death.
https://www.fda.gov/news-events/press-announcements/fda-approves-first-oral-antiviral-treatment-covid-19-adults?utm_medium=email&utm_source=govdelivery
#publichealth #DrugDevelopment #Antiviral #Paxlovid #nirmatrelvir #COVID19
Martin Michaelis · @MartMichaelis
26 followers · 366 posts · Server mastodonapp.ukEvidence that oral antivirals have a beneficial impact on #COVID19 in high-risk patients. #nirmatrelvir #molnupiravir #Paxlovid
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2804227
#COVID19 #nirmatrelvir #molnupiravir #Paxlovid
Giuseppe Michieli · @GMIK69
57 followers · 1089 posts · Server mstdn.science
#Nirmatrelvir - #resistant #SARS-CoV-2 is efficiently transmitted in female Syrian #hamsters and retains partial susceptibility to #treatment https://www.nature.com/articles/s41467-023-37773-6
#nirmatrelvir #resistant #sars #hamsters #Treatment
Anita Y Cheng · @anitaycheng
277 followers · 293 posts · Server mastodon.publicinterest.townNirmatrelvir given within 5 days of positive #COVID test reduced the risk of #LongCOVID no matter your vaccination or reinfection status. Dr. Griffin said between metformin and #nirmatrelvir, he’d go with studying nirmatrelvir further, since the mechanism to help with LC is more understood. 5/
#COVID #longcovid #nirmatrelvir #twivtldr
Martin Michaelis · @MartMichaelis
26 followers · 313 posts · Server mastodonapp.uk
#Nirmatrelvir/ #Paxlovid may reduce the risk of #LongCovid .
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2802878
#nirmatrelvir #Paxlovid #LongCovid
TrangAston :verified: · @CastlTrAstonDrs
1192 followers · 2089 posts · Server med-mastodon.com
#IDmastodon @IDSAInfo This 1 st #casereport of successful treatment of persistent #SARSCoV2 infection & OP in an immunocompromised patient using an extended course of #remdesivir in combination with an extended course of #nirmatrelvir/ritonavir.
📌 https://academic.oup.com/cid/article/76/5/923/6771205
📌 https://academic.oup.com/cid/article/76/5/926/6795102
📌 https://academic.oup.com/cid/issue/76/5
#IDMastodon #CaseReport #SarsCoV2 #remdesivir #nirmatrelvir
Giuseppe Michieli · @GMIK69
54 followers · 968 posts · Server mstdn.science
[Articles] #Effectiveness of #nirmatrelvir–ritonavir in preventing #hospital #admissions and #deaths in people with #COVID19: a cohort study in a large #US health-care system https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00118-4/fulltext?rss=yes
#effectiveness #nirmatrelvir #hospital #admissions #deaths #COVID19 #us
TrangAston :verified: · @CastlTrAstonDrs
1159 followers · 1866 posts · Server med-mastodon.com
#Immunopharmacology #IDmastodon @JAMAInternalMed #Paxlovid know your #COVID19 Drugs .Common Drug Interactions With #Nirmatrelvir & #Ritonavir Story From the Front Lines
📌 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2801429?guestAccessKey=731b2fd7-b7a4-4bf8-aee3-fdaef1ece064&utm_source=twitter&utm_medium=social_jamaim&utm_term=8966395629&utm_campaign=article_alert&linkId=202308444
📌 https://jamanetwork.com/journals/jamainternalmedicine/currentissue
#immunopharmacology #IDMastodon #Paxlovid #COVID19 #nirmatrelvir #ritonavir
Giuseppe Michieli · @GMIK69
54 followers · 968 posts · Server mstdn.science[Comment] Real-world #effectiveness of #nirmatrelvir–ritonavir against #BA4 and #BA5 #omicron #SARS-CoV-2 #variants https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00056-7/fulltext?rss=yes
#effectiveness #nirmatrelvir #BA4 #BA5 #omicron #sars #variants
Giuseppe Michieli · @GMIK69
54 followers · 968 posts · Server mstdn.science[Articles] Real-world use of #nirmatrelvir–ritonavir in #outpatients with #COVID19 during the era of #omicron #variants including #BA4 and #BA5 in #Colorado, #USA: a retrospective cohort study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00011-7/fulltext?rss=yes
#nirmatrelvir #outpatients #COVID19 #omicron #variants #BA4 #BA5 #Colorado #usa
Giuseppe Michieli · @GMIK69
54 followers · 968 posts · Server mstdn.science#Efficacy #comparison of #3CLpro #inhibitors #ensitrelvir and #nirmatrelvir against #SARS-CoV-2 in vitro and in vivo https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad027/7033725?rss=1
#efficacy #comparison #3clpro #inhibitors #ensitrelvir #nirmatrelvir #sars
好好引用 · @betterquote
1978 followers · 969 posts · Server alive.bar子陵在听歌
2023-01-09https://weibo.com/1251560221/MnseR2Rx3
#新型冠状病毒 SARS-CoV-2是一个正链#RNA病毒，不是#逆转录病毒，它没有#逆转录酶。#阿兹夫定 是一个活性不强的#HIV 逆转录酶#抑制剂，对SARS-CoV-2没有#抗病毒活性。而#Paxlovid 中的有效成分#Nirmatrelvir 是用最先进的#药化设计 方法根据SARS-CoV-2蛋白酶Mpro（3CL）#构象结构 修饰出来的（https://weibo.com/1251560221/LbrLu7UAZ ）。
阿兹夫定没有任何发表在#同行审阅 杂志上的有效性#临床试验 结果（https://weibo.com/7597822550/Mn9EBCRlo ）。Paxlovid的有效性#3期临床试验 结果发表在全世界最权威的医学杂志#NEJM 上，是目前唯一能降低SARS-CoV-2病毒载量的#小分子抗病毒药（https://weibo.com/1251560221/M4Ut7y5TQ ）；在其上市后多个独立的第三方机构在权威#医学杂志 上发表了其真实世界有效性数据。
其实每个国家都有相关政策保护自己的#民族工业，对我而言，这并不陌生。如果去翻我之前的微博，我在微博上追踪了#抗病毒药 十几年，见证了很多重磅抗病毒药在#CDE 和#医保局 来来回回洽谈多年，比如#DTG 和#必妥维。HIV药物可以用几年来谈，但是在#重大传染病 #公共卫生 危机中，还用惯性方法去处理危机，可见一些机构的优先级是什么。当然，没有医学#科学训练、也非#医药卫生行业 从业者的人可能为此叫好，但接受过相关训练的从业者则无话可说。
———— ⁂ ————
分析#阿兹夫定 的#临床试验数据：一个打死不冤的伪#新冠特效药
Y博的科普园 一个生物狗的科普小园 2023-01-07 https://mp.weixin.qq.com/s/IrIfACWflj6ZwGe6CqHERw
申明：仅代表个人观点，不代表任何组织与单位
这几天有报道说阿兹夫定的#三期临床试验 公布，显著缩短核酸转阴时间。这个药之前写过很多，#有效性极为可疑，安全性上的#遗传、#生殖毒性 问题更无法解决（详见二条）。
但很多人还在问，所以就去看了所谓显示有效的#巴西 三期临床试验，其实根本谈不上显示有效性，部分内容也与之前相关药企IPO文件里提到的其它#临床试验 结果冲突。此药能上架就已荒唐，如果你有（不）幸拿到阿兹夫定，扔了算了。
#新型冠状病毒 #RNA病毒 #逆转录病毒 #逆转录酶 #阿兹夫定 #hiv #抑制剂 #抗病毒活性 #Paxlovid #nirmatrelvir #药化设计 #构象结构 #同行审阅 #临床试验 #3期临床试验 #nejm #小分子抗病毒药 #医学杂志 #民族工业 #抗病毒药 #cde #医保局 #DTG #必妥维 #重大传染病 #公共卫生 #科学训练 #医药卫生行业 #临床试验数据 #新冠特效药 #三期临床试验 #有效性极为可疑 #遗传 #生殖毒性 #巴西
好好引用 · @betterquote
1978 followers · 969 posts · Server alive.bar子陵在听歌
2023-01-09https://weibo.com/1251560221/MnseR2Rx3
#新型冠状病毒 SARS-CoV-2是一个正链#RNA病毒，不是#逆转录病毒，它没有#逆转录酶。#阿兹夫定 是一个活性不强的#HIV 逆转录酶#抑制剂，对SARS-CoV-2没有#抗病毒活性。而#Paxlovid 中的有效成分#Nirmatrelvir 是用最先进的#药化设计 方法根据SARS-CoV-2蛋白酶Mpro（3CL）#构象结构 修饰出来的（https://weibo.com/1251560221/LbrLu7UAZ ）。
阿兹夫定没有任何发表在#同行审阅 杂志上的有效性#临床试验 结果（https://weibo.com/7597822550/Mn9EBCRlo ）。Paxlovid的有效性#3期临床试验 结果发表在全世界最权威的医学杂志#NEJM 上，是目前唯一能降低SARS-CoV-2病毒载量的#小分子抗病毒药（https://weibo.com/1251560221/M4Ut7y5TQ）；在其上市后多个独立的第三方机构在权威#医学杂志 上发表了其真实世界有效性数据。
其实每个国家都有相关政策保护自己的#民族工业，对我而言，这并不陌生。如果去翻我之前的微博，我在微博上追踪了#抗病毒药 十几年，见证了很多重磅抗病毒药在#CDE 和#医保局 来来回回洽谈多年，比如#DTG 和#必妥维。HIV药物可以用几年来谈，但是在#重大传染病 #公共卫生 危机中，还用惯性方法去处理危机，可见一些机构的优先级是什么。当然，没有医学#科学训练、也非#医药卫生行业 从业者的人可能为此叫好，但接受过相关训练的从业者则无话可说。
———— ⁂ ————
分析#阿兹夫定 的#临床试验数据：一个打死不冤的伪#新冠特效药
Y博的科普园 一个生物狗的科普小园 2023-01-07 https://mp.weixin.qq.com/s/IrIfACWflj6ZwGe6CqHERw
申明：仅代表个人观点，不代表任何组织与单位
这几天有报道说阿兹夫定的#三期临床试验 公布，显著缩短核酸转阴时间。这个药之前写过很多，#有效性极为可疑，安全性上的#遗传、#生殖毒性 问题更无法解决（详见二条）。
但很多人还在问，所以就去看了所谓显示有效的#巴西 三期临床试验，其实根本谈不上显示有效性，部分内容也与之前相关药企IPO文件里提到的其它#临床试验 结果冲突。此药能上架就已荒唐，如果你有（不）幸拿到阿兹夫定，扔了算了。
#新型冠状病毒 #RNA病毒 #逆转录病毒 #逆转录酶 #阿兹夫定 #hiv #抑制剂 #抗病毒活性 #Paxlovid #nirmatrelvir #药化设计 #构象结构 #同行审阅 #临床试验 #3期临床试验 #nejm #小分子抗病毒药 #医学杂志 #民族工业 #抗病毒药 #cde #医保局 #DTG #必妥维 #重大传染病 #公共卫生 #科学训练 #医药卫生行业 #临床试验数据 #新冠特效药 #三期临床试验 #有效性极为可疑 #遗传 #生殖毒性 #巴西