The EMBO Journal · @embojournal
532 followers · 265 posts · Server sciencemastodon.com
#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481
#march5 #nlrp3 #ubiquitination #mitochondrial #inflammasome
The EMBO Journal · @embojournal
411 followers · 99 posts · Server sciencemastodon.com
Which #immune pathways (beyond #TLRs) control #otitis media and #COPD-inducing #Moraxella catarrhalis #infection?
Si-Ming Man and colleagues from Australian National University reveal requirement for #guanylate-binding GBP proteins and #caspase11-#NLRP3 #inflammasomes
#immune #tlrs #otitis #copd #moraxella #infection #guanylate #caspase11 #nlrp3 #inflammasomes
· @batresearch
88 followers · 171 posts · Server mstdn.scienceRT @Lo_Zanzi
#WeekendRead! #TheMoreTheMerrier & #InterferonPower! Acetate derived from #microbiota is sensed by GPR43 & facilitates #NLRP3-dependent #MAVS aggregation on #mitochondria thus potentiating #IFN production & protecting against #IAV #influenza @NatureComms http://Doi.org/10.1038/s41467-023-36323-4
#weekendread #themorethemerrier #interferonpower #microbiota #nlrp3 #mavs #mitochondria #IFN #iav #influenza
Giuseppe Michieli · @GMIK69
54 followers · 968 posts · Server mstdn.science#CASP4/11 contributes to #NLRP3 #activation and #COVID19 #exacerbation https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad037/7034150?rss=1
#casp4 #nlrp3 #activation #COVID19 #exacerbation
Thiago Carvalho · @cyrilpedia
1523 followers · 4594 posts · Server qoto.org'Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung #inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action of GF remain unknown. In this study, we identified mitochondrial Src family kinases (mSFKs) as key determinants of GF-induced #NLRP3 #inflammasome activation.'
#inflammation #inflammasome #nlrp3
C. Harris Floudas · @chfloudas
31 followers · 143 posts · Server mstdn.socialRT @CancerDoc: #NLRP3 #inflammasome is a double-edged sword in #cancer. NLRP3 activation can be associated with hyper-progression on #PD1 #immunotherapy https://www.science.org/doi/abs/10.1126/scitranslmed.abq7019
#oncology
#oncology #immunotherapy #pd1 #cancer #inflammasome #nlrp3
Filip Janku · @CancerDoc
41 followers · 21 posts · Server med-mastodon.com#NLRP3 #inflammasome is a double-edged sword in #cancer. NLRP3 activation can be associated with hyper-progression on #PD1 #immunotherapy https://www.science.org/doi/abs/10.1126/scitranslmed.abq7019
#nlrp3 #inflammasome #cancer #pd1 #Immunotherapy