Notch activation revealed to be an important stepping stone on the path to acquiring anterior-posterior identity and mesodermal fate during axis elongation.

Very interesting work from @a_tsakiridis, Fay Cooper & colleagues in Sheffield using human pluripotent cell-based models, plus some lovely chick embryo grafting data from Kim Dale's lab in Dundee

#PaperThemeTune "I'm Notch Your Stepping Stone" by the Monkees

#DevBio #StemCells #Hox #Notch #NMPs

https://www.biorxiv.org/content/10.1101/2023.06.16.545269v1

RT @loicaroyer
We noticed in the #scRNAseq data how strikingly central the #NMPs are. Zooming into our RNA velocity we can see indeed two branches going to the neural and mesodermal lineages. Our data even suggest a transcriptomic connection to the notochord and floor plate! 14/n