I am excited to share my review paper on "The Contribution of the #LocusCoeruleus–#Noradrenaline System Degeneration during the Progression of #Alzheimer's Disease" 🤩 It is now online, you can check it out to learn latest updates😊 @DZNE_en
mdpi.com/2007082 @Biology_MDPI

Is there anything the #LC can't do.?

“...activation of LC NEergic signaling during CFC memory encoding mediates engram early tagging in the mPFC and systems consolidation of remote memory“

Noradrenergic signaling mediates cortical early tagging and storage of remote memory | Nature Communications
https://www.nature.com/articles/s41467-022-35342-x

#systemsneuro #noradrenaline

Funny how things sometimes coincide.

Yesterday I posted about a science article reporting that midbrain #dopamine might not be the reward prediction error signal we thought.
https://www.science.org/doi/10.1126/science.abq6740

Today, this preprint about #noradrenaline possibly being that reward prediction error.

https://www.biorxiv.org/content/10.1101/2022.12.08.519670v1

#neuroscience

With recent controversy and excitement in the #dopamine world, next comes this gem on the role of the #LC and #noradrenaline in prediction error-based learning

https://www.biorxiv.org/content/10.1101/2022.12.08.519670v1?s=08

Here, the authors showed that during decision-making, differential responses of #LC neurons match reward probabilities. Further, inhibition of the #LC disrupted learning based on #RPE

This validates another causal role for #LC heterogeneity /modularity that directly affects decision-making

Check out what the #LocusCoeruleus is doing when a mouse mother is retrieving a pup, and the #noradrenaline it releases into the ACC!

Very cool new work by Steve Shea's team: https://www.biorxiv.org/content/10.1101/2022.12.04.519053v1

In 2014, still a postdoc with Isabelle Mansuy, I screened for #noradrenaline sensitive genes (using microarrays.. 😱) in the #hippocampus after acute swim stress. The top stress-induced gene was always *Apold1*. For years since we kept seeing Apold1 in every experiment! Apo-WHAT?

Does anyone have experience with Elvanse as a patient or a mental health professional?
I am wondering is, amongst others, whether taking it would make one's body even less able to produce its own dopamine + noradrenaline in the long run, and whether a depressive episode or even chronic depression is to be expected when one stops taking it.
Grateful for boosting / more visibility.
Thank you!
#adhd
#elvanse
#dopamine
#noradrenaline

A series of extremely cool #locuscoeruleus manuscripts have been put out there recently, and I wanna take the opportunity to highlight them in this🧵

Would love input from other #bluespot enthusiasts, since I'm definitely missing papers!

Maybe we can keep adding by replying, and eventually create an easily accessible list of publications that currently shape the #LC field

🔵

#systemsneuro #neuroscience #noradrenaline #preprints

Before I overthink my "first post"*:

Interests: medicine/neuroscience; biologic changes in & treatment for #PTSD, #TBI, and #LongCovid; #sleep & autonomic function; trauma; catecholamine (esp #noradrenaline ) regulation; climate change. #R programmer & stats by necessity.

Help me figure out who to connect with here?

*excluding posts on Twitter, Facebook, MySpace, Friendster, LiveJournal, and some BBS that I used to talk about nerdy books and play VGA planets back in high school....