Interaction between components of #MicrotubuleOrganizingCenters & #NuclearPores (Bfa1/Bub2 & Nup159) that facilitates autophagic degradation of a pool of #nucleoporin complexes and may favor specific elimination in the daughter cell @FMC_lab #PLOSBiology https://plos.io/45gNH7q

In issue 13:
Highlight on #FBXL4 E3 controlling basal mitophagy via NIX/#BNIP3 degradation
#Salicylic acid attenuates #brassinosteroid signaling by removing S-acylation from proteins
#Nucleoporin foci as stress-sensitive condensates
Mechanism of #botulinum #neurotoxin presynaptic targeting
Cover: Natalia Prevarskaya and coworkers
https://www.embopress.org/toc/14602075/2023/42/13

What is the significance of cytoplasmic #nucleoporin foci for nuclear pore formation?
G. Seydoux et al show them to form condensates in response to stress and advanced age in vivo, but to be dispensable for C. elegans nuclear pore assembly
https://www.embopress.org/doi/10.15252/embj.2022112987

📣 Time to toot some Hippo🦛 & Podocyte🐙 - News:

Nucleoporins and the Hippo signaling effectors YAP/TAZ might balance each other to keep podocytes sound.

Please find the latest preprint from our CRU329 project:

https://www.biorxiv.org/content/10.1101/2023.03.07.531564v1

A huge THANK YOU to our Hippo team working hard to decipher more details.

#Podocyte #FSGS #Nephrology #HippoSignaling #Nucleoporin #CellBiology #KFO329 #CRU329 #RareDisease #GlomerularDisease

@UniKoeln @CECAD
@nephrology @biorxivpreprint