The EMBO Journal · @embojournal
500 followers · 241 posts · Server sciencemastodon.com
How do mitochondria obtain the #ribonucleotides they need for organellar transcription?
Thomas MacVicar, Thomas Langer and colleagues show key fueling role of #mitochondrial #nucleoside diphosphate kinase #NME6 that phosphorylates #pyrimidine nucleosides
https://www.embopress.org/doi/full/10.15252/embj.2022113256
#ribonucleotides #mitochondrial #nucleoside #nme6 #pyrimidine
Marco Radi · @marcoradi
192 followers · 133 posts · Server qoto.org
#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200
#nucleoside #antiviral #medchem #drugdiscovery #antimicrobial #BroadSpectrum #chemistry #ChemMedChem
CellBioNews · @cellbionews
61 followers · 1455 posts · Server scientificnetwork.de#Nucleoside analogs for messenger #RNA metabolic labeling and #sequencing.
https://phys.org/news/2023-06-nucleoside-analogs-messenger-rna-metabolic.html
Chemistry Research · @organic_chemistry
57 followers · 43 posts · Server mstdn.social
Carbasugar #nucleoside analogues often lack biological activity, which is attributed to an unfavorable conformation. Locked nucleoside analogues, however, can mantain the ribose-like conformation. Another synthetic access is published in #OrgLett by Lak Shin Joeng and colleagues from Seoul National University (S. #Korea)
They were able to report the synthesis of the conformationally locked cytidine nucleoside analogue in 19 steps.
#chemistry #MedChem @chemistry
https://pubs.acs.org/doi/10.1021/acs.orglett.2c03853
#medchem #chemistry #korea #orglett #nucleoside
Joseph P. · @tonic
229 followers · 118 posts · Server mstdn.scienceIt is expected to be a promising agent in the treatment of various ailments and diseases.
Adenosine can be metabolized both externally and internally. Externally, an enzyme called adenosine deaminase is responsible for transforming adenosine into inosine. Additionally, a protein called equilibrative #nucleoside #transporters (ENTs) helps to bring the #extracellular activity of adenosine to an end.
#nucleoside #transporters #extracellular
beSpacific · @bespacific
34 followers · 93 posts · Server newsie.socialA #multivalent #nucleoside-#modified #mRNA #vaccine #against #all #known #influenza #virus #subtypes - Arevalo et al. #developed a nucleoside-modified messenger #RNA-#lipid #nanoparticle #vaccine #encoding #hemagglutinin #antigens from all 20 known #influenza A and B virus subtypes https://www.science.org/doi/10.1126/science.abm0271#.Y4DMJ5gdYY4.twitter
#multivalent #nucleoside #modified #mrna #vaccine #against #all #known #influenza #Virus #subtypes #developed #RNA #lipid #nanoparticle #encoding #hemagglutinin #antigens
Giuseppe Michieli · @GMIK69
3 followers · 50 posts · Server mstdn.scienceA multivalent #nucleoside-modified #mRNA #vaccine against all known #influenza virus subtypes, https://www.science.org/doi/abs/10.1126/science.abm0271
#nucleoside #mrna #vaccine #influenza