Changes in adenoviral #chromatin organization precede early gene activation upon infection
Harald Wodrich, Gernot Laengst and colleagues show that host #nucleosomes replace #adenoviral genome packaging before viral genes are transcribed.
https://www.embopress.org/doi/full/10.15252/embj.2023114162
#chromatin #nucleosomes #adenoviral
New microscopy assay by Sue Biggins and collaborators #fredhutch enables direct observation of coordinated de novo assembly of native #CENPA #nucleosomes driven by several protein cofactors and the AT run content of #centromeric DNA
#RefereedPreprint c/o @ReviewCommons
https://www.embopress.org/doi/10.15252/embj.2023114534
#fredhutch #cenpa #nucleosomes #centromeric #refereedpreprint
How the #epigenetic landscape modulates pioneer #transcription factor binding.
#nucleosomes #Yamanaka #histones
https://phys.org/news/2023-05-epigenetic-landscape-modulates-transcription-factor.html
#epigenetic #transcription #nucleosomes #yamanaka #histones
Surprises from #FLIM-#FRET studies of nanometer-range distances between #nucleosomes in living, non-fixed cells:
Claire Dupont, Robert Feil, David Lleres et al show that constitutive #heterochromatin is in fact less compacted than bulk #chromatin
#flim #fret #nucleosomes #heterochromatin #chromatin
How the 'master #regulators' of cells make #DNA accessible for gene #expression.
https://phys.org/news/2023-04-master-cells-dna-accessible-gene.html
#regulators #dna #expression #nucleosomes #cbf1
#DNA #packaging supports #cell division, finds study.
#mitosis #replication #ORC #nucleosomes
https://phys.org/news/2023-04-dna-packaging-cell-division.html
#dna #packaging #cell #mitosis #replication #orc #nucleosomes
The molecular basis for recognition of #CENPA #nucleosomes by ‘Mis18 licensing factor component #KNL2:
Tatsuo Fukagawa and coworkers present #cryoEM structure with chicken KNL2 and insight into its dynamic localization regulation during the #cellcycle
https://www.embopress.org/doi/10.15252/embj.2022111965
#cenpa #nucleosomes #knl2 #cryoem #cellcycle
Check out our collection of 3D printed #Nucleosomes and explore how DNA winds around and protected by histones. buff.ly/3HSPDZC