What a viral study criticizing cancer screening gets very, very wrong

https://www.statnews.com/2023/09/07/cancer-screening-harms-lifespan-critique/

#healthcare #medicine #science #oncology #cancer #cancerscreening

Our brief review of research (as opposed to blogposts/social media posts) on applications of #LLM chatbots in #oncology care. Not a COVID19-style boom, but I expect a lot more to come along as use cases get identified and people start getting creative.

https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1268915/full

This is interesting - providing individualised antibiotic plans safely reduces #carbapenem prescriptions.

But isn't this just what happens in specialties, like #hematology or #intensivecare, that get regular #microbiology / #infectiousdisease #MDT review of their #antibiotic prescriptions?
#IDmastodon #medicine #oncology #orthopedics #ICU #AMR #pediatrics #criticalcare
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad518/7255898?redirectedFrom=fulltext&utm_source=advanceaccess&utm_campaign=cid&utm_medium=email

The growth of the amount of ‘Turbo Cancer’ cases is worrying experts. https://www.theepochtimes.com/health/mrna-covid-vaccines-may-be-triggering-aggressive-turbo-cancers-in-young-people-experts-5375766

#ConsciousLiving #Health #Cancer #Oncology #Medicine @consciousliving

'7 minute cancer jab' sounds a bit of a marketing spin.

#OncoPharm #TootRx #oncology #Atezolizumab

But we will take any capacity gains we can!

Wondering if we will see any #BOPA23 postings on here for the 25th Annual Symposium in October. #Newport #Cardiff #Wales

If #crossposting worked I'd post from here to X during symposium.

#oncology #pharmacy #oncopharm #tootRx

New ChemRxiv preprint! “Pitfalls and considerations in determining the potency and mutant selectivity of covalent #EGFR inhibitors.” Collaboration between our group and AssayQuant Technologies, Inc. #MedicinalChemistry #oncology https://chemrxiv.org/engage/chemrxiv/article-details/64e50861dd1a73847f5020a1

Study suggests the right dietary fat could help boost #platelet counts https://medicalxpress.com/news/2023-08-dietary-fat-boost-platelet.html via
@medical_xpress
#Oncology #Nutrition

A multidisciplinary cross-Canada team co-lead by @ubcmedicine's François Bénard and #SFUChemistry professor Caterina Ramogida is developing radioactive isotopes for the precision treatment of late-stage cancers. https://www.sshrc-crsh.gc.ca/funding-financement/nfrf-fnfr/stories-histoires/2023/fight_cancer-lutter_contre_le_cancer-eng.aspx #sfu #sfuscience #chemistry #oncology #cancer

I just wrote a sentence in a #priorauth denial appeal letter that I really liked. Sharing it here for other #physicians:

“If you deny this test, you are effectively practicing medicine without a license and going against the standards of care in oncology”

#fixpriorauth #patientcare #oncology #insurancedenials #MedMastodon

@katiefenn yups. My OH is at work right now, fucking cancer hard for us all. #oncology 😘

TITLE: Long Covid’s Brain Fog Is Akin to "Aging Ten Years"—N=3,000

Once again -- Thank you Dr. Pope for your summaries.

----FORWARDED---
Smithsonian Magazine includes an article: “Long Covid’s Brain Fog Is Akin to ‘Aging Ten Years,’ Study Finds—Scientists tested the cognitive function of more than 3,000 participants and found those with longer-lasting Covid symptoms had the strongest decline.”

Here are some excerpts:

People struggling with “long Covid,” or the persistence of symptoms after an initial Covid-19 infection, can face cognitive difficulties such as “brain fog” and memory problems. Now, a study finds the severity of these symptoms is comparable to the brain aging ten years.

By testing the mental speed and accuracy of participants who had and had not been diagnosed with Covid-19, researchers found the cognitive decline was worst for people who had experienced Covid symptoms for more than 12 weeks, according to a study published this month in eClinicalMedicine, a journal published by The Lancet.

“The fact remains that two years on from their first infection, some people don’t feel fully recovered, and their lives continue to be impacted by the long-term effects of the coronavirus,” Claire Steves, a co-author of the study who researches aging and mental health at King’s College London, says in a statement.

<snip>

Since the Covid-19 pandemic’s early days, scientists have raced to understand the symptoms associated with long Covid, such as depression, major fatigue, brain fog and even dementia.

In 2020, a separate team of researchers examined the brains of people who had died from Covid-19 and discovered their blood vessels, which were covered with antibodies, had sustained significant damage, reports Time’s Jamie Ducharme. The scientists concluded the virus had somehow caused the body’s immune system to attack its blood vessels, leading to inflammation in the brain.

It’s not clear whether this inflammation is the cause of brain fog and cognitive difficulties in living patients with long Covid, but Lara Jehi, a researcher at the Cleveland Clinic who was not involved in the current study or the 2020 research, tells Time she’s seen it impact both people with long Covid and Alzheimer’s disease. “We found many areas of overlap between the two, and these areas of overlap centered on…inflammation in the brain and microscopic injuries to the blood vessels,” she tells the publication.

To better understand long Covid’s effect on the brain, the new study put more than 3,000 participants through 12 different types of cognitive tests designed to measure memory, processing speed, attention, motor control and other thinking skills. A little over half of the participants had previously tested positive for Covid-19, and all were recruited through the Covid Symptom Study Biobank smartphone app.

In the first round of testing in 2021, researchers found the cognitive impairment associated with long Covid was clear, comparable to the brain being under “mild or moderate symptoms of psychological distress,” or ten years of aging, write the authors in the paper.

During the second round of testing, which took place in 2022, patients showed no significant improvement. At that point, some participants’ cognitive decline had lasted nearly two years after infection.

The positive takeaway? Once a person’s Covid symptoms disappeared—regardless of whether they had persisted for three months or one week—their cognitive function appeared to recover.

This, at least, is “good news,” says Nathan Cheetham, a senior postdoctoral data scientist at King’s College London and study co-author, in the statement.

“This study shows the need to monitor those people whose brain function is most affected by Covid-19, to see how their cognitive symptoms continue to develop and provide support toward recovery,” he says in the statement.

About 15 percent of U.S. adults have experienced long Covid, according to the Household Pulse Survey by the National Center for Health Statistics. In the United Kingdom, about two million adults were impacted by the persistent condition as of January 2023, reports the Guardian’s Geneva Abdul.

Steves calls for more research into how long Covid victims can be aided in their recovery process, especially those who have been living with the symptoms for years.

“We need more work to understand why this is the case and what can be done to help,” she says in the statement.

Ken Pope

Hector Y. Adames, Nayeli Y. Chavez-Dueñas, Melba J.T. Vasquez, & Ken Pope:
Succeeding as a Therapist: How to Create a Thriving Practice in a Changing World (APA, 2022)

Ken Pope, Melba J.T. Vasquez, Nayeli Y. Chavez-Dueñas, & Hector Y. Adames:
Ethics in Psychotherapy & Counseling: A Practical Guide, 6th Edition (Wiley, 2021)

~~~
#psychology #counseling #socialwork #psychotherapy #research @psychotherapist @psychology @socialpsych @socialwork #Vaccines #COVID #longcovid #oncology #science #medicine #brain #neurology #brainfog

A New Mode of Cancer Treatment

'As detailed in a paper published in Cell Chemical Biology, researchers have developed a "cancer-killing pill" capable of destroying solid tumors while leaving healthy cells unaffected. The new drug has been in development for 20 years and is now undergoing pre-clinical research in the U.S.'

#science #medicine #health #cancer #oncology

https://science.slashdot.org/story/23/08/04/1951259/a-new-mode-of-cancer-treatment

WEBSITE FINALLY ONLINE! :-DDD
https://www.cymanticmedical.com/

#nextgen #cancer #breastcancer #lungcancer #tumor #savelives #science #AI #surgery #CYMANTICMEDICAL #Oncology #UCD #Dublin

WEBSITE FINALLY ONLINE! :-DDD
https://www.cymanticmedical.com/

#nextgen #cancer #pathology #breastcancer #lungcancer #tumor #savelives #science #AI #Microscopy #surgery #CYMANTICMEDICAL #Oncology #UCD #Dublin

"mRNA vaccines do not stop with COVID-19"

Making #COVID19 a springboard to development in other areas of #medicine, like #cancer #oncology
#mRNA #vaccines #vaccine

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01514-3/fulltext?dgcid=raven_jbs_aip_email

Why our #biotech and #pharma clients turn into OmicsChart's champions🏆 ? Because we make sure that our results serve our clients long after handover.

Many providers treat #bioinfomatics project deliverables as the end goal. But the project doesn't end when service provision does. The true deliverable of a #bioinformatics consulting is not a table, a graph or a report, but a perspective that can be used to drive decisions 🎯

#biomarkers #oncology #immunooncology #rwe #rwd

🌻We’re preparing #TumorBoardTuesday!

🧑‍🔬Join Dr Maryam Lustberg & Dr Adriana Kahn 08.01.23 8pm ET, for a walk through TNBC tx while pt on IS for #Crohns

🌻Don’t miss this essential MDT chat!

🧠Grab FREE #CME credits
👉🏽Visit integrityce.com/TBT2023 for more info

@JohnEbbenMDPhD @MPishvaian #OncoDon #PrecisionMedicine #Oncology #IBD #PrecisionOncology #BreastCancer #Cancer

Email2Toot ROBOT -- CHECK ACTUAL AUTHOR BELOW:
EMAIL LIST: https://www.clinicians-exchange.org & LEMMY: https://lem.clinicians-exchange.org
.

TITLE: COVID-19 news

-------- Forwarded Message -------

Disclaimer: The data in this column come from either mainstream news
media sources or scientific research published in peer-reviewed
journals (each category can be determined by following the links in
the reference section). This column's author acknowledges the cultural
bias of the world scientific community in its belief that the
scientific method is the most viable available alternative for
assessing COVID-19 and its effects in an objective manner through a
structured process of observable and repeatable hypothesis testing.

Summary:

In 2022, COVID-19 was the underlying (primary) or contributing cause
in the chain of events leading to 244,986 deaths that occurred in the
United States.(see "COVID-19 Mortality Update — United States, 2022"
under Virology & Epidemiology).

Physicians advocating vaccination and other COVID-19 safety protocols
have experienced an alarming increase in threats against them. In an
August 2022 survey of emergency doctors conducted by the American
College of Emergency Physicians, 85% of respondents said violence
against them is increasing. One in four doctors said they're being
assaulted by patients and their family and friends multiple times a
week, compared to just 8% of doctors who said as much in 2018.
Sixty-four percent of emergency physicians reported receiving verbal
assaults and threats of violence; 40% reported being hit or slapped,
and 26% were kicked (see "When Did Medicine Become a Battleground for
Everything?" under Media News).

Research indicates genetics determine severity of COVID-19 symptoms
and propensity for long COVID (see "From Asymptomatic COVID to Long
COVID: Genetic Underpinnings" under Virology & Epidemiology).

Seroprevalnece correlates with confirmed COVID cases among children
(see "SARS-CoV-2 Seroprevalence Compared With Confirmed COVID-19 Cases
Among Children, Colorado, USA, May–July 2021" under Vaccines,
Treatment & Testing).

Research findings suggest that use of kidneys from donors with active
or resolved COVID-19 is safe, with excellent outcomes during
medium-term follow-up, which may be useful information for kidney
transplant professionals and patients. Further research is needed to
determine longer-term transplant outcomes, but the investigators
suggest that if the donor has good kidney function at the time of
procurement with no proteinuria, risk for kidney disease is minimal in
long-term follow-up (see "Does COVID-19 Affect Donor Kidney Outcomes?"
under COVID Complications).

Doctors who treat patients with long COVID, hampered by a lack of
federally approved treatments, are turning to off-label use of drugs
designed for addiction, diabetes, and other conditions (see "Off-Label
Meds: Promising Long COVID Treatments?" under Vaccine, Treatment and
Testing).

COVID-19 remains the 4th leading cause of death in the US (see
"Provisional Mortality Data — United States, 2022" under Media News).

Facebook removed content related to Covid-19 in response to pressure
from the Biden administration, including posts claiming the virus was
man-made, according to internal company communications (see "Facebook
Bowed to White House Pressure, Removed Covid Posts" under Policy).

The May 11, 2023 termination of the PHE has made it increasingly
difficult to accurately track COVID-19 new cases or fatalities.
However, new variants of concern continue to emerge, with consequent
infections and deaths.

Since the termination of the PHE, data on vaccination rates are no
longer being tracked. The last known US COVID-19 vaccination rates
(May 10, 2023) are as follows: full
vaccination (two initial doses) 69.3%; at least one updated booster
dose: 17% (see "Track Covid-19 in the U.S." under
Vaccines, Treatment & Testing). "Our World in Data" stopped trying to
track US booster rates on August 30, 2022 and shows a flat line since
then.

****************************
Virology & Epidemiology:

COVID-19 Dashboard by the Center for Systems Science and Engineering
(CSSE) at Johns Hopkins University (JHU):
https://coronavirus.jhu.edu/map.html
and
https://coronavirus.jhu.edu/region/united-states

Our World in Data:
https://ourworldindata.org/coronavirus-data

Worldometer:
https://www.worldometers.info/coronavirus/

Health Equity Tracker:
https://healthequitytracker.org/exploredata?gclid=Cj0KCQjw-4SLBhCVARIsACrhWLUL78j0e9QYUZtcHe_eMhwzCgsIqClo1P9-7GVeRfEW8ewY8Xi7o0QaApCmEALw_wcB

COVID-19 Mortality Update — United States, 2022:
https://www.medscape.com/viewarticle/991669?ecd=wnl_edit_tpal_etid5651082&uac=397605ET&impID=5651082

From Asymptomatic COVID to Long COVID: Genetic Underpinnings:
https://www.medscape.com/viewarticle/994575?ecd=wnl_dne1_230721_MSCPEDIT_etid5666277&uac=397605ET&impID=5666277

*******************************************
Vaccines, Treatment & Testing:

Current U.S. COVID Vaccination Rate:
https://www.google.com/search?q=us+covid+vaccination+rate&rlz=1C1CHBF_enUS936US936&oq=us+covid+vaccination+rate+&aqs=chrome..69i57j0i512l7j0i457i512j0i512.4456j0j7&sourceid=chrome&ie=UTF-8

Track Covid-19 in the U.S.:
https://www.nytimes.com/interactive/2023/us/covid-cases.html

SARS-CoV-2 Seroprevalence Compared With Confirmed COVID-19 Cases Among
Children, Colorado, USA, May–July 2021:
https://www.medscape.com/s/viewarticle/993096?src=FYE

Off-Label Meds: Promising Long COVID Treatments?:
https://www.medscape.com/viewarticle/994728?src=FYE

*****************************************
Policy:

Facebook Bowed to White House Pressure, Removed Covid Posts:
https://www.wsj.com/articles/facebook-bowed-to-white-house-pressure-removed-covid-posts-2df436b7?mod=djem10point

******************************************
COVID Complications:

Does COVID-19 Affect Donor Kidney Outcomes?
https://www.medscape.org/viewarticle/993750?sso=true&impID=5670993&uac=397605ET&src=wnl_tpal_230722_mscpedu

******************************************
Media News:

When Did Medicine Become a Battleground for Everything?:
https://www.medscape.com/viewarticle/994502?ecd=WNL_trdalrt_pos1_230720_etid5664597&uac=397605ET&impID=5664597

Provisional Mortality Data — United States, 2022:
https://www.medscape.com/viewarticle/991670?src=FYE

****************************************

Hoping that is helpful information--

Chuck

Charles M. Lepkowsky, Ph.D.
Solvang, CA

#psychology #counseling #socialwork #psychotherapy #research
@psychotherapist @psychology @socialpsych
@socialwork #Vaccines #COVID #longcovid #oncology #science
#medicine

The global chemo-therapy drug market is $43 billion (2021 Data Bridge Market Research). Just imagine what would happen to that business if a cure for cancer was finally found/revealed.
#chemo_therapy #medicine #pharma #cancer #oncology