Ever try to #drug an #oncoprotein only to have the #tumor lose its dependency on it and become drug resistant? Introducing #RIPTACs (Regulated Induced Proximity Targeting Chimeras) in collaboration with #Halda Therapeutics. RIPTACs selectively kill cells by differentially accumulating an antiproliferative agent via an induced Protein:Protein Interaction (#PPI) to a differentially expressed protein. Importantly, target protein function is not needed for RIPTAC action.
https://biorxiv.org/cgi/content/short/2023.01.01.522436v1