Bose-Einstein-Kondensat · @MWNautilus
99 followers · 10 posts · Server mstdn.social
Bose-Einstein-Kondensat · @MWNautilus
99 followers · 10 posts · Server mstdn.social
Gaspar Jekely · @jekely
366 followers · 1 posts · Server biologists.social

Our favourite now in the mammalian brain as a new tool!

"Here we ... found that the Platynereis dumerilii ciliary opsin ... is an efficient, versatile, light-activated bistable GPCR that can suppress synaptic transmission in mammalian neurons with high temporal precision in-vivo "

biorxiv.org/content/10.1101/20

#platynereis #opsin #optogenetic #neuroscience #gpcr

Last updated 1 year ago

Jonas Wietek :vibing: · @JWietek
328 followers · 180 posts · Server mstdn.science

🚨 preprint alert🚨
Check out PdCO:
Light-controlled inhibition of synaptic transmission via the inhibitory pathway.

Link:

#optogenetic #GPCR #optogenetics #neuroscience

Last updated 1 year ago

The vOICe vision · @seeingwithsound
374 followers · 1152 posts · Server mas.to

A clinically viable approach to restoring visual function using cell.com/molecular-therapy-fam "Chronos-expressing vectors were efficacious over a broad range of vector doses and stimulating light intensities, and were well tolerated";

#blindness #therapy #gene #optogenetic

Last updated 1 year ago

Brian Knutson · @knutson_brain
664 followers · 1115 posts · Server sfba.social

Ingenious manipulation of the heart and brain (i.e., posterior insula) shows that heart rate can modulate, but does not mediate, uncertainty-based arousal (in mice, by my clever colleagues):
nature.com/articles/s41586-023

#optogenetic #stanford

Last updated 2 years ago

seeingwithsound · @seeingwithsound
335 followers · 704 posts · Server mas.to
seeingwithsound · @seeingwithsound
262 followers · 378 posts · Server mas.to

#optogenetic

Last updated 2 years ago

I mean, count the number of publications with successful manipulations versus successful manipulations that influence behavior in NHPs and draw your own conclusions about which is a more fruitful strategy for neuromodulation

#chemogenetic #optogenetic

Last updated 2 years ago

Joachim Goedhart · @JoachimGoedhart
664 followers · 210 posts · Server mas.to

New from our lab πŸŽ‰ :toot:
We report an iLID-nanobody fusion to enable recruitment to . This is potentially interesting when you already have a cell line or model organism expressing a GFP fusion protein.
biorxiv.org/content/10.1101/20

#GFP #optogenetic #preprint

Last updated 2 years ago

Joachim Goedhart · @JoachimGoedhart
890 followers · 320 posts · Server mas.to

New from our lab πŸŽ‰ :toot:
We report an iLID-nanobody fusion to enable recruitment to . This is potentially interesting when you already have a cell line or model organism expressing a GFP fusion protein.
biorxiv.org/content/10.1101/20

#GFP #optogenetic #preprint

Last updated 2 years ago

DocLarus · @ShahafPeleg
2 followers · 4 posts · Server sciencemastodon.com