Greetings from California! 🇺🇸
PhD student Alice Orme is spending her #IMPRS research stay at the Geological and Planetary Sciences division of #CalTech. She's hosted by John Eiler & Alex Sessions to learn how to analyze position-specific #isotopes using #Orbitrap👩‍🔬.
#IMPRSabroad

Luckily, PSM rescoring using predicted fragment ion intensities (with tools such as #Prosit, #MS2Rescore, etc.) can significantly improve the immunopeptidomics results over standard sequence database searching. 💪

Unfortunately, existing fragment ion intensity prediction models have been developed for #Orbitrap instruments. In contrast, #timsTOF instruments are increasingly popular for immunopeptidomics due to their increased sensitivity.