A molecular network map of orexin-orexin receptor signaling system. https://doi.org/10.1007/s12079-022-00700-3 #Orexin #Pathvisio #Sleep #Feeding #Hypothalamus

For #neuropeptide afficionados:
Interesting new paper from James Checco's lab on two #Aplysia #allatotropin / #orexin receptors, one activated by a D-peptide the other one by an L-peptide.
Conversion of an L-stereoisomer to a D-stereoisomer is a big mystery in peptide biology - but it matters for rec specificity and lifetime.
https://www.pnas.org/doi/10.1073/pnas.2217604120