Check out the lab's work: https://liberalilab.org/

They get biopsies from #human patients then can make #organoids from single stem cells, and study development and regeneration of all cell types, with custom culture media they developed (!)

Their #intestinal organoids are very similar to early development, showing fetal gene expression signature

Lacramioara Bintu from Stanford introducing the first speaker of the conference! She is Prisca Liberali from FMI in Basel, joining us virtually.

"Decoding the design principles of tissue organization"

Model system is intestinal #organoids
#selforganization

#CSSingleCells23

One #stemcell can generate an entire, organized, organoid

#multiplexed #SingleCell analysis of organoids, using to understand #regeneration after intestinal damage

A screen with 400K organoids and 3000 compounds!

1/2

Tiny faux organs could crack mystery of #menstruation
No one is entirely sure how/why—human body choreographs monthly dance of cellular birth, maturation, & death. Many people desperately need treatments to make #period more manageable, but it’s difficult for scientists to design #medications w/o understanding how menstruation works. Research is still very much in infancy. But #organoids have already provided insights into how endometrial cells communicate and coordinate
https://www.technologyreview.com/2023/08/18/1077537/menstruation-mystery/

Check out the latest issue of our TUMcampus magazine! Learn more about #sustainablenutrition in urban areas, how #organoids can help fight #cancer, and take a look inside the #Cheops pyramid: http://go.tum.de/816653

#sustainability

📷Israel Tan Si Lie

How do morphogen signals instruct stem cells to acquire a specific neuronal identity? A #preprint by Neal Amin, Kevin Kelley and team provides us with a roadmap. 🧫 🛣️ 🧠

Great new #preLight from Monica Tambalo which includes a response from the authors...👀

#preLight 👉 https://prelights.biologists.com/highlights/generating-human-neural-diversity-with-a-multiplexed-morphogen-screen-in-organoids/

#morphogens #organoids #StemCells #neuroscience

Postdoctoral Fellow

the MRC Laboratory of Molecular Biology (LMB)

Postdoctoral position in neuroscience and brain organoids at the MRC Laboratory of Molecular Biology (LMB), Cambridge, UK.

See the full job description on jobRxiv: https://jobrxiv.org/job/the-mrc-laboratory-of-molecular-biology-lmb-27778-postdoctoral-fellow/?feed_id=48838

#ScienceJobs #hiring #research #organoids, #...
https://jobrxiv.org/job/the-mrc-laboratory-of-molecular-biology-lmb-27778-postdoctoral-fellow/?feed_id=48838

Postdoctoral Fellow

the MRC Laboratory of Molecular Biology (LMB)

Postdoctoral position in neuroscience and brain organoids at the MRC Laboratory of Molecular Biology (LMB), Cambridge, UK.

See the full job description on jobRxiv: https://jobrxiv.org/job/the-mrc-laboratory-of-molecular-biology-lmb-27778-postdoctoral-fellow/?feed_id=48033

#ScienceJobs #hiring #research #organoids, #...
https://jobrxiv.org/job/the-mrc-laboratory-of-molecular-biology-lmb-27778-postdoctoral-fellow/?feed_id=48033

Join our next We are MIBE Talk on June 14 where Alessandra Moretti will talk about her research in the fields of stem cell biology and cardiac development. In addition, Julian Grünewald will present his research on engineering CRISPR strategies for heart disease: go.tum.de/901381

#StemCells #organoids #HeartDiseases #BiomedicalEngineering

Scientists demonstrate 3D '#bio_printing' inside #organoids growing in hydrogels.

https://phys.org/news/2023-06-scientists-3d-bio-printing-organoids-hydrogels.html

All of the data and code is also available:

🔢 Source Data: download on paper website
🧬 http://bit.ly/3IWc69y
📸 http://bit.ly/3CelnWR
👩‍💻 http://bit.ly/3IWcrJm
🏗️ http://bit.ly/3OYPppd

#openaccess #OpenScience #cancer #organoids #breastcancer

Our new paper on a platform to leverage bioprinted cells to measure single-organoid resolution response to therapy is out today!

#organoids #cancer #paper #science

https://www.nature.com/articles/s41467-023-38832-8

Out new preprint is out!
#sarcoma #organoids #science

https://www.biorxiv.org/content/10.1101/2023.05.25.542375

Out new preprint is out!
#sarcoma #organoids #science

<iframe src="https://qoto.org/@biorxivpreprint/110440493949112714/embed" class="mastodon-embed" style="max-width: 100%; border: 0" width="400" allowfullscreen="allowfullscreen"></iframe>

Working out how to add blood vessels to brain #organoids has posed a challenge. This Perspective looks at innovative approaches to brain organoid vascularization, including those put forward in a 2020 #PLOSBiology paper. #neuroscience https://plos.io/42aZseB

Researchers succeeded in modelling the development of the brain and its #ImmuneSystem using #organoids. They are grown from #PluripotentStemCells and can be used to study diseases of the human brain in a new way: http://go.tum.de/118035

#microglia #autism

📷A. Heddergott

❤️ Our organoids make our hearts beat!

🔬 You are watching the video of a beating cardioid obtained from human stem cells at early stage of differentiation. Our scientists from the Automated Stem Cell and Organoid Facility immortalized these pulsating organoids, allowing us to observe the intricate dance of life at a microscopic level, using Axiocam 208 color camera, AXIO microscope, Zeiss.

#lifesciences #humantechnopole #organoid #organoids #stemcell #stemcells

How to feed mini-organs

Organoids, lab-grown mini-organs, hold the promise for better understanding of human biology. But these microscopic organ-like blobs of cells fall short of real organs in a lot of ways. For one, their size is limited to less than half of a millimeter in diameter — any larger and their internal cells start dying because nutrients from the liquid they’re grown in can’t diffuse past a certain distance. Scientists are now making lab-grown mini-organs more lifelike by adding blood vessels.

#Biomedicine #Biotechnology #Organoids #BloodVessels #BrainOrganoids #Neuroscience #Neurology

https://alleninstitute.org/news/scishots-how-to-feed-mini-organs/

So happy and proud to see the work of my PhD buddy Catarina @catarinacsmc out! 🤩
Such an amazing scientist and friend. Congrats!!

They investigated corpus callosum agenesis using human neural organoids. Check it out!
---
RT @catarinacsmc
😶‍🌫️🤩 It's out!
So happy to share a big piece of my PhD work with the world. 🧩

Using human neural #organoids, we investigated corpus callosum agenesis, a disconnection between the two #brain hemisph…
https://twitter.com/catarinacsmc/status/1654235710998585348

Interested in groundbreaking #biointerfaces for functional recording of #neuronal activity in 2D and #3D model systems? #organoids

Meet @denizphd at #FRM2023 ☀️ Algarve ☀️ !

Also: If you are a #neuroscience PhD/PostDoc currently looking for opportunities, feel free to come by!

#Human #airway and #nasal #organoids reveal escalating replicative #fitness of #SARS-CoV-2 emerging #variants, https://doi.org/10.1073/pnas.2300376120