Marc Robinson-Rechavi · @marcrr
934 followers · 1687 posts · Server ecoevo.social
Marc Robinson-Rechavi · @marcrr
902 followers · 1566 posts · Server ecoevo.socialAnnouncing #SIB Comparative genomics course, taught by Christophe Dessimoz, Natasha Glover, @rmwaterhouse and myself, 30 August - 01 September in Lausanne #UNIL
• Introduction to molecular evolution & phylogenetics
• Orthology-focused arthropod comparative genomics
• Duplication of genes and genomes, expression
with #SIB resources #OMA, #Orthodb #BUSCO and @bgeedb #ortholog #orthologs #paralog #duplication #MolecularEvolution #Genomics #bioinformatics #training @P_Palagi https://www.sib.swiss/training/course/20230830_COMGE
#SIB #UNIL #oma #orthodb #busco #ortholog #orthologs #paralog #duplication #MolecularEvolution #Genomics #bioinformatics #training
Bgee database · @bgeedb
45 followers · 45 posts · Server genomic.socialThese observations of conserved homologous expression are easy to reproduce! Go to a gene page, click "orthologs", and chose a taxonomic level, here Theria:
TLK1 https://bgee.org/gene/ENSG00000198586/#orthologs -> https://bgee.org/analysis/expr-comparison?data=4a7fc4f9fba1b1e63c458881a6ca8f5b61367fd2
HAT1 https://bgee.org/analysis/expr-comparison?data=d9510c624d21931605aa16a7c378f8ede9ce4fe6
#bioinformatics #biocuration #evodevo #ortholog #homology
#bioinformatics #biocuration #evodevo #ortholog #homology
Marc Robinson-Rechavi · @marcrr
839 followers · 1193 posts · Server ecoevo.socialMarc Feuermann: PAN-GO phylogenetic annotation of @go, implicitly relying on the #ortholog conjecture for annotation, mapping the changes in function to duplication nodes (my interpretation) #biocuration2023
Bgee database · @bgeedb
40 followers · 26 posts · Server genomic.social
Bgee used to support the identification of the target gene for depletion experiment in zebrafish: https://elifesciences.org/articles/83652
#zebrafish #cytoskeleton #ortholog #paralog #GeneExpression #SIB @dee_unil @marcrr
#zebrafish #cytoskeleton #ortholog #paralog #geneexpression #SIB
Marc Robinson-Rechavi · @marcrr
448 followers · 299 posts · Server ecoevo.social@iddux @JoannaMasel @gethemudo Does paralog evolve to #paralog more frequently than ortholog evolves to #ortholog, and if yes is it because of lack of constraints or is it adaptive?
Marc Robinson-Rechavi · @marcrr
443 followers · 289 posts · Server ecoevo.socialWill be fun to remember this later if #ScienceMastodon takes off: right now my posts seem to be the only hits for #ortholog and #paralog.
#ScienceMastodon #ortholog #paralog
Silas Kieser · @silask
43 followers · 21 posts · Server mstdn.scienceRT @marc_rr
Orthologs, lots of #orthologs!
#OrthoDB: 17 551 bacteria, 607 archea, 1935 eukaryotes https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac998/6814468
#EggNOG: 10 756 bacteria, 457 archaea, 1322 eukaryotes https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1022/6833261
#orthologs #orthodb #eggnog #bioinformatics #ortholog #databases
Marc Robinson-Rechavi · @marcrr
432 followers · 276 posts · Server ecoevo.socialOrthologs, lots of #orthologs!
#OrthoDB: 17 551 bacteria, 607 archea, 1935 eukaryotes https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac998/6814468
#EggNOG: 10 756 bacteria, 457 archaea, 1322 eukaryotes https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1022/6833261
#orthologs #orthodb #eggnog #bioinformatics #ortholog #databases
Marc Robinson-Rechavi · @marcrr
343 followers · 210 posts · Server ecoevo.social
Now published in its final form: Parallel evolution of amphioxus and vertebrate small-scale gene duplications by Brasó-Vives et al
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02808-6
#EvoDevo #EvolutionaryBiology #Genomics #Amphioxus #Chordate #ortholog #paralog #GeneDuplication
#evodevo #EvolutionaryBiology #Genomics #Amphioxus #chordate #ortholog #paralog #geneduplication
Marc Robinson-Rechavi · @marcrr
289 followers · 192 posts · Server ecoevo.social
Very exciting preprint led by Manu Irimia on evolution of tissue-specificity of expression in vertebrates and insects, providing great data, evidence for "low conservation of tissue-specific expression profiles", and tissue-specific gains associated with duplications and with the emergence of unique phenotypes
https://www.biorxiv.org/content/10.1101/2022.11.14.516384v1
#geneexpression #EvolutionaryBiology #TissueSpecifity #ortholog #paralog #DeneDuplication
#geneexpression #EvolutionaryBiology #tissuespecifity #ortholog #paralog #deneduplication