Distinct mechanisms of #PTEN inactivation in dogs and humans highlight convergent molecular events that drive cell division in the pathogenesis of #osteosarcoma.
https://www.sciencedirect.com/science/article/pii/S2210776223000327

Canine #Osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery

https://www.frontiersin.org/articles/10.3389/fvets.2022.965391/full

Natural Killer and T Cell Infiltration in Canine #Osteosarcoma: Clinical Implications and Translational Relevance https://www.frontiersin.org/articles/10.3389/fvets.2021.771737/full

Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in #Osteosarcoma

https://www.frontiersin.org/articles/10.3389/fvets.2021.704598/full

Adoptive Natural Killer Cell Immunotherapy for Canine #Osteosarcoma https://www.frontiersin.org/articles/10.3389/fvets.2021.672361/full

Genomic and Transcriptomic Characterization of Canine #Osteosarcoma Cell Lines: A Valuable Resource in Translational Medicine

https://www.frontiersin.org/articles/10.3389/fvets.2021.666838/full

MicroRNA Expression Changes and Integrated Pathways Associated With Poor Outcome in Canine Osteosarcoma https://www.frontiersin.org/articles/10.3389/fvets.2021.637622/full #Osteosarcoma

Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma https://www.frontiersin.org/articles/10.3389/fvets.2021.637614/full #Osteosarcoma

The case study focuses on one of the comparisons ("Poor Response" group) in the #EURAMOS-1 trial in #osteosarcoma.
That trial team had already set up for extensive international accrual, but rare diseases are difficult to recruit to.

Improving Osteosarcoma Treatment: Comparative Oncology in Action. https://www.mdpi.com/2075-1729/12/12/2099 #Osteosarcoma

https://www.greyhoundhealthinitiative.org/sarcomas/

Greyhound Health Initiative summarizes #osteosarcoma in #greyhounds, symptoms, prognosis and treatment including emerging immunotherapy.

See the "Do You Need Help with Diagnosis or Treatment" GHI and founder Dr. Couto (semii-retired teaching/researching DVM) consults on labs, imagry, and treatment planning.

Dr. C was the goto vet for racing greyhound owners needing help with a difficult injury.

#dogs #HoundsOfMastodon

Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. https://www.frontiersin.org/articles/10.3389/fvets.2022.965391/full #Osteosarcoma #oncology

#Dogs may hold the key to treating #osteosarcoma and other #human #cancers

https://www.naturalnews.com/2022-12-02-canines-may-hold-key-treating-human-cancers.html

#Dogs may hold the key to treating #osteosarcoma and other #human #cancers

https://www.naturalnews.com/2022-12-02-canines-may-hold-key-treating-human-cancers.html

We got some bad news today. Our 7 yr old Pippa #greyhound has bone cancer and unfortunately it spread to her lungs. Leg amputation and aggressive chemo early on could not stop it. #Osteosarcoma is very bitter. We’ll be with Pippa to the end. We’ll spend the next weeks doing fun things, serving lots of grilled steak, and the rest of our lives, cherishing this brave little girl. :-(

Antitumor Activity of an anti-EGFR/HER2 Bispecific Antibody in a Mouse Xenograft Model of Canine #Osteosarcoma. https://www.mdpi.com/1999-4923/14/11/2494

#Osteosarcoma bone cancer: Little boy who lost leg to rare cancer sadly dies | Exclusive
#9newsaus #9news https://www.9news.com.au/national/bone-cancer-osteosarcoma-chandler-tran-boy-who-lost-leg-to-rare-cancer-sadly-dies/7a163113-7da7-4d95-8f4d-7d19982a6a37