Phase 1 clinical trial underway to test City of Hope-developed cancer treatment https://www.news-medical.net/news/20230801/Phase-1-clinical-trial-underway-to-test-City-of-Hope-developed-cancer-treatment.aspx
โResults have been promising. #AOH1996 can suppress tumor growth as a monotherapy or combination treatment in cell and animal models without resulting in toxicity.
AOH1996 has been effective in preclinical research treating cells derived from #breast, #prostate, #brain, #ovarian, #cervical, #skin and #lung #cancersโ
#aoh1996 #breast #prostate #brain #ovarian #cervical #skin #Lung #cancers
#DYK #ovarian #cancer is one of the most common cancers for โ๏ธ in ๐ with ~ 68k new cases in 2020?
@Pmsilvamendes @unibirmingham developed ๐ screening tools to detect ๐๏ธovarian cancer early ๐ https://bit.ly/428zjwh
#MissionCancer #EWAC2023 #nanotechnology @EUScienceInnov
๐ฆ๐: https://n.respublicae.eu/ERC_Research/status/1663923392234524673
#DYK #ovarian #cancer #MissionCancer #EWAC2023 #nanotechnology
New drug combination offers #ovarian #cancer breakthrough
๐ The phase 2 trial, led by the Royal Marsden NHS Foundation Trust and the Institute of Cancer Research (London) tested the drug #avutometinib alone and in combination with #defactinib in 29 patients.
๐ Trial results show almost half the patients on the new drug combination(45%) saw their tumours shrink significantly, almost twice as effective as the next best treatment โ trametinib (response rate of 26%)
#ovarian #cancer #avutometinib #defactinib
Set up in my calendar is a reminder that on this day, now 9 years ago, I was diagnosed with Stage 3 #Ovarian #cancer Two things about this. I've survived and apparently, I'm a miracle (the odds of survive for ovarian cancer are dire). The other is that it was my husband who set this reminder up in my calendar. Not long after I'd had my diagnosis and was undergoing treatment, he was diagnosed with Oesophageal cancer. 8 years ago, he died. So... yay, I lived to tell tale, but...
Endocrine-disrupting compounds (EDCs) one of which perfluorooctanoic acid (PFOA), currently used in #kitchenware, food packaging, cleaning products, and #fireproofing foam can be detected in #blood, #urine and #breastmilk can disrupt endocrine system leading #femaleinfertility and #hormonalimbalances
Effect of PFOA exposure on diminished #ovarian reserve and its metabolism
https://rbej.biomedcentral.com/articles/10.1186/s12958-023-01056-y
#MedMastodon #caution #infertilityawarenessweek #maleinfertility #foodsecurity #healthcare
#kitchenware #fireproofing #blood #urine #breastmilk #femaleinfertility #hormonalimbalances #ovarian #MedMastodon #caution #infertilityawarenessweek #maleinfertility #foodsecurity #healthcare
A certain type of #immunotherapy in which the body's T cells are programmed to attack #cancer cells, called CAR-T cell therapy, is effective in #ovarian cancer mice.
#Medical #sflorg
https://www.sflorg.com/2023/02/med02062301.html
#immunotherapy #cancer #ovarian #medical #sflorg
Cannabis and ovarian cancer: continuing Michelle Kendallโs legacy
This new article on Cannabis Health News tells the story of my dear Michelle's struggle to overcome #OvarianCancer using #MedicalCannabis and the research that we launched to study how #Cannabis might be a treatment for this terrible disease.
The article summarizes our recently published study showing how cannabis can kill #ovarian #cancer cells in a lab context.
#ovariancancer #medicalcannabis #cannabis #ovarian #cancer #cannabisismedicine #cancerwarrior
โข Maternal #circadian disruption before pregnancy damaged the #ovarian function in female offspring.
โข The changes of lipid #metabolism and ovarian immune microenvironment may explain for the impaired ovarian function of the chronodisrupted offspring.
https://www.sciencedirect.com/science/article/abs/pii/S004896972208264X
#circadian #ovarian #metabolism
Although #ovarian #cancer is the deadliest type of cancer for #women, only about 20% of cases are found at an early stage, as there are no real screening tests for them and few symptoms to prompt them.
#ArtificialIntelligence #AI #Engineering #Biology #Medical #sflorg
https://www.sflorg.com/2022/11/eng11292201.html
#ovarian #cancer #women #artificialintelligence #ai #engineering #biology #medical #sflorg
Although #ovarian #cancer is the deadliest type of cancer for #women, only about 20% of cases are found at an early stage, as there are no real screening tests for them and few symptoms to prompt them.
#ArtificialIntelligence #AI #Engineering #Biology #Medical #sflorg
https://www.sflorg.com/2022/11/eng11292201.html
#ovarian #cancer #women #artificialintelligence #ai #engineering #biology #medical #sflorg
Mutations of #BRCA1 and #BRCA2 #genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as #ovarian, #breast, #pancreatic and #prostate #cancer.
#Medical #Biology #sflorg
https://www.sflorg.com/2022/11/med11282201.html
#brca1 #brca2 #genes #ovarian #breast #pancreatic #prostate #cancer #medical #biology #sflorg
A New #Antibody Approach to Fight #Ovarian #Cancer | A unique immunotherapy-based antibody approach has been developed which targets #cancers consisting of solid tumours. Ovarian cancer is the seventh most common cancer in #women
https://www.scientificeuropean.co.uk/medicine/a-new-antibody-approach-to-fight-ovarian-cancer/
#antibody #ovarian #cancer #cancers #women
#introduction
Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
I mainly do #ComputationalBiology and supervise a team that does the wet work.
Trying to create a focused work engagement in this account
#introduction #ovarian #cancer #PARP #FunctionalGenomics #MAVE #dms #DeepMutationalScanning #computationalbiology