What is the role of #DNAdamage #kinase #DNAPKcs in the cellular response to #oxidative stress?

Benjamin Chen at UT Southwestern, Hsinyu Lee at National Taiwan University, and coworkers implicate it as part of a #checkpoint that modulates #ANT2-#VDAC2-mediated ADP-ATP exchange over #mitochondrial membranes to limit #OXPHOS-derived ROS

https://www.embopress.org/doi/10.15252/embj.2022112094

Recent studies have shown that #AcuteMyeloidLeukemia favors #OxPhos metabolism. This #ASH22 abstract from my colleagues demonstrates with in vitro and in vivo models that the use of #ammocidin, an inhibitor of electron transport chain complex V, works synergistically with low-dose #venetoclax to kill #AML cells. Stop by poster 2652 or read more about it here: https://ashpublications.org/blood/article/140/Supplement%201/5959/492144/Electron-Transport-Chain-Complex-V-Inhibition #leukemia #cancer #oncology #hematology #hemonc #science #medicine

Latest curated articles👇🏽
📰 Islet dysfunction in T2D through multidimensional pancreatic phenotyping (HPAP in 📷)
📰Independent respiratory chains adapt #OXPHOS performance to glycolytic switch
🧊Precise DNA cleavage by CRISPR-SpRYgests
🔗http://biomed.news/bims-nimamd/2022-10-09
🙏🏽Thx@biomednews